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1.发明公开
公开(公告)号：EP2970975A4
公开(公告)日：2016-11-02
申请号：EP14763633
申请日：2014-03-14
发明人： CLARKE MICHAEL F , ADORNO MADDALENA
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/1137 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K31/713 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12N2330/51 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , C12Y301/02015
摘要： Methods and compositions are provided for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal. Aspects of the methods include inhibiting H2A deubiquitinating enzyme activity in cells, e.g. by administering an effective amount of an H2A deubiquitinating enzyme antagonist. Also provided are screens to identify therapeutics for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal.
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2.发明公开SINGLE CELL GENE EXPRESSION FOR DIAGNOSIS, PROGNOSIS AND IDENTIFICATION OF DRUG TARGETS 有权单细胞基因表达诊断，预后和ACTIVE目标识别
公开(公告)号：EP2389453A4
公开(公告)日：2012-10-03
申请号：EP10733816
申请日：2010-01-20
发明人： CLARKE MICHAEL F , QUAKE STEPHEN R , DALERBA PIERO D , LIU HUIPING , LEYRAT ANNE , KALISKY TOMER , DIEHN MAXIMILLIAN , WANG JIANBIN
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/5023 , G01N33/57484 , G01N2800/52
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3.发明公开METHODS AND SYSTEMS FOR ANALYSIS OF SINGLE CELLS 有权VERFAHREN UND SYSTEME ZUR ANALYZE VON EINZELZELLEN
公开(公告)号：EP2596006A4
公开(公告)日：2014-04-16
申请号：EP11810302
申请日：2011-07-19
发明人： CLARKE MICHAEL F , QUAKE STEPHEN R , DALERBA PIERO D , LIU HUIPING , LEYRAT ANNE , KALISKY TOMER , DIEHN MAXIMILIAN , ROTHENBERG MICHAEL , WANG JIANBIN , LOBO NEETHAN
CPC分类号： C12N15/1072 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Methods are provided for diagnosis and prognosis of disease by analyzing expression of a set of genes obtained from single cell analysis. Classification allows optimization of treatment, and determination of whether on whether to proceed with a specific therapy, and how to optimize dose, choice of treatment, and the like. Single cell analysis also provides for the identification and development of therapies which target mutations and/or pathways in disease-state cells.
摘要翻译： 通过分析从单细胞分析获得的一组基因的表达，为疾病的诊断和预后提供方法。 分类允许优化治疗，确定是否进行特定治疗，以及如何优化剂量，治疗选择等。 单细胞分析还提供了鉴定和开发针对疾病状态细胞中的突变和/或途径的疗法。
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