公开(公告)号：EP2970975A1

公开(公告)日：2016-01-20

申请号：EP14763633.6

申请日：2014-03-14

申请人： The Board of Trustees of The Leland Stanford Junior University

发明人： CLARKE, Michael F. ,  ADORNO, Maddalena

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2330/51 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Y301/02015

摘要： Methods and compositions are provided for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal. Aspects of the methods include inhibiting H2A deubiquitinating enzyme activity in cells, e.g. by administering an effective amount of an H2A deubiquitinating enzyme antagonist. Also provided are screens to identify therapeutics for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal.

摘要翻译： 提供了用于治疗与降低的干细胞自我更新速率相关的医学病症或将对增加的干细胞自我更新速率有反应的方法和组合物。 方法的各方面包括抑制细胞中的H2A去泛素化酶活性，例如， 通过施用有效量的H2A去泛素化酶拮抗剂。 还提供筛选以鉴定用于治疗与降低的干细胞自我更新速率相关的医学病症或将对增加的干细胞自我更新速率有反应的治疗剂。

公开(公告)号：EP1989320A4

公开(公告)日：2010-04-07

申请号：EP07750788

申请日：2007-02-14

申请人： HARVARD COLLEGE ,  SANOFI AVENTIS

发明人： KING RANDALL W ,  LYMAN SUSAN ,  CHUNG EUNAH ,  NATESAN SRIDARAN ,  EPSTEIN CHARLES B

IPC分类号： C12P19/34 ,  C12N9/12 ,  C12N9/64 ,  G01N33/68

CPC分类号： G01N33/5011 ,  C12N9/1205 ,  C12Q1/37 ,  C12Q1/485 ,  C12Y207/11001 ,  C12Y301/02015

公开(公告)号：EP2895183B1

公开(公告)日：2018-10-24

申请号：EP13763220.4

申请日：2013-09-13

申请人： F. Hoffmann-La Roche AG

发明人： BINGOL, Baris ,  CORN, Jacob ,  ZHANG, Yingnan

IPC分类号： A61K38/00 ,  C07K7/08 ,  C12N15/113 ,  A61P25/16 ,  A61P25/00 ,  A61P3/00

CPC分类号： A61K38/005 ,  C07K7/08 ,  C07K14/8103 ,  C12N9/485 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y301/02015 ,  C12Y304/19012

摘要： Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided.

公开(公告)号：EP2205746A4

公开(公告)日：2010-12-22

申请号：EP08835168

申请日：2008-10-04

申请人： UNIV TEXAS

发明人： SCHWARTZ JACOB C ,  YOUNGER SCOTT T ,  JANOWSKI BETHANY A ,  COREY DAVID R

IPC分类号： C12N15/113 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  C07H21/00 ,  C12N15/63 ,  C12N15/67

CPC分类号： C12N15/635 ,  C12N15/111 ,  C12N15/67 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2320/50 ,  C12N2330/10 ,  C12N2830/34 ,  C12N2830/36 ,  C12Y301/02015 ,  C12N2310/3525

公开(公告)号：EP2895183A1

公开(公告)日：2015-07-22

申请号：EP13763220.4

申请日：2013-09-13

申请人： F.Hoffmann-La Roche AG

发明人： BINGOL, Baris ,  CORN, Jacob ,  ZHANG, Yingnan

IPC分类号： A61K38/00 ,  C07K7/08 ,  C12N15/113 ,  A61P25/16 ,  A61P25/00 ,  A61P3/00

CPC分类号： A61K38/005 ,  C07K7/08 ,  C07K14/8103 ,  C12N9/485 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y301/02015 ,  C12Y304/19012

摘要： Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided.

摘要翻译： 提供USP30的抑制剂和使用USP30抑制剂的方法。 在一些实施方案中，提供了治疗涉及线粒体缺陷的病症的方法。

公开(公告)号：EP2859356A2

公开(公告)日：2015-04-15

申请号：EP13803712.2

申请日：2013-06-11

申请人： Nodality, Inc. ,  Cesano, Alessandra ,  Rosen, David ,  Fantl, Wendy J. ,  Hawtin, Rachael

发明人： CESANO, Alessandra ,  ROSEN, David ,  FANTL, Wendy, J. ,  HAWTIN, Rachael

IPC分类号： G01N33/68

CPC分类号： G01N33/57415 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y301/02015 ,  G01N33/5011 ,  G01N33/505 ,  G01N33/57449 ,  G01N33/6875 ,  G01N33/6893 ,  G01N2333/9108 ,  G01N2510/00 ,  G01N2800/52

摘要： The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.

公开(公告)号：EP2459717A1

公开(公告)日：2012-06-06

申请号：EP10739454.6

申请日：2010-07-30

申请人： New York Blood Center, Inc.

发明人： CHEN, Ying ,  HUANG, Cheng-han ,  YE, Mao

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K31/713

CPC分类号： C12N15/113 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y207/07049 ,  C12Y301/02015

摘要： Methods and compositions are disclosed for inhibiting cell proliferation and diagnosing and treating cancer comprising antagonists or inhibitors of the WDR79 protein. Also disclosed are methods for screening compounds for WDR79 inhibitory or antagonist activity.

公开(公告)号：EP2446883A1

公开(公告)日：2012-05-02

申请号：EP10189534.0

申请日：2010-10-30

申请人： University College Cork-National University of Ireland, Cork

发明人： Carmody, Ruadhri, Dr.

IPC分类号： A61K31/00 ,  A61K31/4015 ,  G01N33/50 ,  A61P29/00 ,  A61P9/00 ,  A61P25/28 ,  A61P35/00 ,  A61P37/06 ,  A61P9/10

CPC分类号： A61K31/00 ,  A61K31/4015 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y301/02015 ,  G01N2333/916 ,  G01N2440/36 ,  G01N2500/02 ,  G01N2800/7095 ,  Y02A50/414

摘要： A method for the treatment of inflammation in an individual is described, for example a causal therapy of a disease or condition for which an inflammatory state is an underlying cause of the disease, or a treatment of inflammation as a symptom of a disease state, for example inflammation caused by cancer, cardiovascular disease, an infection or trauma, by treating the individual with an agent capable of attenuating the activity of Ubiquitin Serine Protease 7 (USP7) protein, in particular a USP7 inhibitor chemical.

摘要翻译： 描述了治疗个体炎症的方法，例如，疾病或病症的因果治疗，其中炎症状态是疾病的根本原因，或作为疾病状态的症状的炎症治疗，用于 例如通过用能够减弱泛素丝氨酸蛋白酶7（USP7）蛋白质，特别是USP7抑制剂化学品的活性的试剂治疗个体，由癌症，心血管疾病，感染或创伤引起的炎症。

公开(公告)号：EP2970975A4

公开(公告)日：2016-11-02

申请号：EP14763633

申请日：2014-03-14

申请人： UNIV LELAND STANFORD JUNIOR

发明人： CLARKE MICHAEL F ,  ADORNO MADDALENA

IPC分类号： C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/1137 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2330/51 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Y301/02015

摘要： Methods and compositions are provided for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal. Aspects of the methods include inhibiting H2A deubiquitinating enzyme activity in cells, e.g. by administering an effective amount of an H2A deubiquitinating enzyme antagonist. Also provided are screens to identify therapeutics for the treatment of medical conditions associated with a reduced rate of stem cell self-renewal or that will be responsive to an increased rate of stem cell self-renewal.

公开(公告)号：EP2859356A4

公开(公告)日：2016-08-03

申请号：EP13803712

申请日：2013-06-11

申请人： NODALITY INC ,  CESANO ALESSANDRA ,  ROSEN DAVID ,  FANTL WENDY J ,  HAWTIN RACHAEL

发明人： CESANO ALESSANDRA ,  ROSEN DAVID ,  FANTL WENDY J ,  HAWTIN RACHAEL

IPC分类号： C12Q1/68 ,  G01N33/566

CPC分类号： G01N33/57415 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/31 ,  C12Y301/02015 ,  G01N33/5011 ,  G01N33/505 ,  G01N33/57449 ,  G01N33/6875 ,  G01N33/6893 ,  G01N2333/9108 ,  G01N2510/00 ,  G01N2800/52

摘要： The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations.