-
1.发明公开ENGINEERED PRIMATE CYSTINE/CYSTEINE DEGRADING ENZYMES AS ANTINEOGENIC AGENTS 有权操纵PRIMATENCYSTIN - / - 半胱氨酸降解酶作为代理人ANTINEOGENE
公开(公告)号：EP3039137A4
公开(公告)日：2017-03-22
申请号：EP14839001
申请日：2014-08-29
申请人： UNIV TEXAS
发明人： GEORGIOU GEORGE , STONE EVERETT
CPC分类号： A61K45/06 , A61K38/51 , C12N9/88 , C12Y404/01001
摘要： Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase comprising one or more amino acid substitutions and capable of degrading L-cyst(e)ine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with L-cyst(e)ine using the disclosed proteins or nucleic acids.
-
2.发明公开ADMINISTRATION OF KYNURENINE DEPLETING ENZYMES FOR TUMOR THERAPY 审中-公开VERABREICHUNG VON KYNURENINABREICHERUNGSENZYMEN ZUR TUMORTHERAPIE
公开(公告)号：EP3038636A4
公开(公告)日：2017-04-26
申请号：EP14840339
申请日：2014-08-29
申请人： UNIV TEXAS
发明人： GEORGIOU GEORGE , STONE EVERETT
CPC分类号： A61K35/17 , A61K38/00 , A61K38/46 , C12N9/14 , C12Y307/01003
摘要： Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
摘要翻译： 描述了使用具有犬尿烯酶活性的蛋白质的方法和组合物。 例如，在某些方面，可以公开能够降解犬尿氨酸的修饰的犬尿氨酸酶。 此外，本发明的某些方面提供了使用所公开的蛋白质或核酸用犬尿氨酸去除治疗癌症的组合物和方法。
-
3.发明公开COMPOSITIONS OF ENGINEERED HUMAN ARGINASES AND METHODS FOR TREATING CANCER 有权操纵人类arginases和方法治疗癌症的组合物
公开(公告)号：EP2350273A4
公开(公告)日：2012-06-27
申请号：EP09824219
申请日：2009-11-02
申请人： UNIV TEXAS
发明人： GEORGIOU GEORGE , STONE EVERETT
CPC分类号： A61K38/50 , A61K33/24 , A61K38/00 , A61K47/48215 , A61K47/60 , C12N9/78 , C12Y305/03001
-
公开(公告)号：EP3186371A4
公开(公告)日：2018-01-10
申请号：EP15834988
申请日：2015-08-28
申请人： UNIV TEXAS
IPC分类号： C12N9/14 , A61K35/14 , A61K35/17 , A61K38/00 , A61K38/46 , A61K39/395 , A61K47/60 , C07K16/28 , C12N9/96
CPC分类号： C07K16/2887 , A61K35/17 , A61K38/00 , A61K39/3955 , A61K47/48215 , A61K47/60 , C07K16/2818 , C07K16/2827 , C07K16/2896 , C07K2317/622 , C07K2319/01 , C12N9/14 , C12N9/96 , C12Y307/01003
摘要： Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.
-
公开(公告)号：EP3039139A4
公开(公告)日：2017-03-01
申请号：EP14841106
申请日：2014-08-29
申请人： UNIV TEXAS
发明人： GEORGIOU GEORGE , STONE EVERETT , LU WEI-CHENG
CPC分类号： C12N9/88 , A61K35/12 , A61K38/51 , A61K45/06 , C12N1/14 , C12N1/20 , C12N5/0601 , C12N15/70 , C12N15/74 , C12N15/79 , C12Y404/01001 , A61K2300/00
摘要： Methods and compositions relating to the engineering of an improved protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
-
-
-
-
搜索结果
5 条记录 (耗时 0.008 秒)
