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公开(公告)号：EP3363460A1
公开(公告)日：2018-08-22
申请号：EP17305173.1
申请日：2017-02-16
申请人： Université Grenoble Alpes , Centre Hospitalier Universitaire Grenoble , Etablissement Français du Sang
发明人： LE GOUELLEC, Audrey , TOUSSAINT, Bertrand , LENORMAND, Jean-Luc , LAURIN, David , MEYNET, Elodie
IPC分类号： A61K39/104 , C12N1/20 , C12N1/36 , C12N15/10 , C12N15/78
CPC分类号： A61K39/104 , A61K2039/522 , C12N1/20 , C12N1/36 , C12N15/78
摘要： The present invention is related to a live-attenuated strain of Pseudomonas for its use as a vaccine, and for use in a method for preventive immunizing and for treating Pseudomonas infection, in particular in patients suffering from cystic fibrosis. Preferably, the live-attenuated strain of Pseudomonas is furthermore treated to become 'killed but metabolically active'.
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公开(公告)号：EP2791318B1
公开(公告)日：2019-06-19
申请号：EP12805669.4
申请日：2012-12-12
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公开(公告)号：EP3582809A1
公开(公告)日：2019-12-25
申请号：EP18706464.7
申请日：2018-02-15
申请人： Université Grenoble Alpes , Centre Hospitalier Universitaire Grenoble Alpes , Etablissement Français du Sang
发明人： LE GOUELLEC, Audrey , TOUSSAINT, Bertrand , LENORMAND, Jean-Luc , LAURIN, David , MEYNET, Elodie
IPC分类号： A61K39/104 , C12N1/20 , C12N1/36 , C12N15/10 , C12N15/78
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公开(公告)号：EP3277298A1
公开(公告)日：2018-02-07
申请号：EP16714856.8
申请日：2016-04-04
发明人： CINQUIN, Philippe , SCHNEIDER, Dominique , MAURIN, Max , MARTIN, Donald , EL ICHI, Sarra , ZEBDA, Abdelkader , ALCARAZ, Jean-Pierre , RECHE, Fabian , TUVIGNON, Patrick , THELU, Jacques , LE GOUELLEC, Audrey , TOUSSAINT, Bertrand
IPC分类号： A61K35/747 , A61F2/00 , A61L31/16 , A61K9/00 , A61M31/00
CPC分类号： A61M31/002 , A61B5/6871 , A61B5/6873 , A61K35/747 , A61K38/28 , A61L31/042 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/43 , A61L2400/18 , A61M25/04 , A61M2210/1053 , A61M2210/1057 , A61M2210/106 , B01D69/144 , Y02A50/473
摘要： The device, that can be implanted in the intestinal cavity, comprises a reactor comprising a semi-permeable or porous membrane or coating linked to a element for attachment to an intestinal or gastric wall. The reactor can be in the form of a ribbon, a structure having more than two faces or an open structure delimiting a lumen, comprising, or formed from, a semi-permeable or porous membrane. The reactor can also delimit, at least partially with the semi-permeable or porous membrane of same, a closed inner space. The reactor can comprise or carry enzymes or micro-organisms, in particular bacteria or yeast. The reactor is used for generating a chemical reaction with one or more molecules present in the intestine, or for producing one or more biologically active molecules. It can, in particular, be used for consuming sugars, disaccharides and simple sugars or producing essential amino acids or other molecules having a positive effect on the health.
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公开(公告)号：EP3768279A1
公开(公告)日：2021-01-27
申请号：EP19718443.5
申请日：2019-03-25
申请人： Institut Polytechnique de Grenoble , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS- , Université Grenoble Alpes , Centre Hospitalier Universitaire Grenoble Alpes
发明人： CHIRAT, Christine , TOUSSAINT, Bertrand , DELOULE, Vivien , CHROBOCZEK, Jadwiga , BOISSET-HELBERT, Claire
IPC分类号： A61K31/715 , A61K31/736 , A61P1/00
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6.发明公开ATTENUATED AND ADAPTED STRAIN OF PSEUDOMONAS FOR DELIVERING ANTIGENS 审中-公开ABGESCHWÄCHTEUND ANGEPASSTE PSEUDOMONAS-STÄMMEZUR FREISETZUNG VON ANTIGENEN
公开(公告)号：EP2791318A1
公开(公告)日：2014-10-22
申请号：EP12805669.4
申请日：2012-12-12
CPC分类号： C12N1/36 , A61K39/0005 , A61K39/0011 , A61K2039/522 , A61K2039/523 , C07K14/435 , C12N1/20 , C12N15/102 , C12N15/78 , C12R1/38
摘要： The invention is related to a process for obtaining an adapted strain of Pseudomonas, comprising the following steps: €¢ deleting the genes ExoS ExoT, aroA and lasI in an initial Pseudomonas strain cultivated in a LB medium, €¢ progressively cultivating this strain in a chemically defined medium based on a glucose minimal medium supplemented with magnesium and calcium, wherein the adapted strain presents the same toxicity and secretion capacities than the initial strain, and its doubling time when cultivated in said chemically defined medium is less than 60 minutes. The present invention is also related to the adapted strain such as obtained,in particular wherein the adapted strain is furthermore treated to become 'killed but metabolically active'.
摘要翻译： 本发明涉及一种获得拟南芥假单胞菌菌株的方法，其包括以下步骤：删除在LB培养基中培养的初始假单胞菌属菌株中的ExoS ExoT，aroA和lasI基因，并逐渐培养该菌株 基于补充有镁和钙的葡萄糖基本培养基的化学上确定的培养基，其中所述适应菌株具有与初始菌株相同的毒性和分泌能力，并且其在所述化学确定的培养基中培养的倍增时间小于60分钟。 本发明还涉及适应的菌株，例如获得的，特别是其中将适应菌株进一步处理成“杀死但代谢活性”。
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