-
公开(公告)号：EP2417151B8
公开(公告)日：2017-05-24
申请号：EP10723209.2
申请日：2010-04-06
申请人： Université Grenoble Alpes , Centre National de la Recherche Scientifique , INSERM - Institut National de la Santé et de la Recherche Médicale
CPC分类号： C07K5/126 , A61K38/00 , A61K38/07 , A61K38/12 , C07K1/107 , C07K1/1075 , C07K1/1077 , C07K5/12 , Y02A50/411
-
公开(公告)号：EP2417151B1
公开(公告)日：2016-09-14
申请号：EP10723209.2
申请日：2010-04-06
申请人： Universite Joseph Fourier (Grenoble 1) , Centre National de la Recherche Scientifique , INSERM - Institut National de la Santé et de la Recherche Médicale
CPC分类号： C07K5/126 , A61K38/00 , A61K38/07 , A61K38/12 , C07K1/107 , C07K1/1075 , C07K1/1077 , C07K5/12 , Y02A50/411
-
公开(公告)号：EP2417151A1
公开(公告)日：2012-02-15
申请号：EP10723209.2
申请日：2010-04-06
申请人： Universite Joseph Fourier (Grenoble 1) , Centre National de la Recherche Scientifique , INSERM - Institut National de la Santé et de la Recherche Médicale
CPC分类号： C07K5/126 , A61K38/00 , A61K38/07 , A61K38/12 , C07K1/107 , C07K1/1075 , C07K1/1077 , C07K5/12 , Y02A50/411
摘要： The present invention relates a method for preparing a cyclic peptide with an anti-parasitic activity and an anticancer activity. The invention also relates to said peptide as an anti-parasitic agent, for example, in treating toxoplasmosis, and as an anti-cancer agent. The invention also relates to the use of said cyclic peptide in the
ex vivo treatment of organs before transplantation.-
公开(公告)号：EP3630995A1
公开(公告)日：2020-04-08
申请号：EP18726151.6
申请日：2018-05-22
-
公开(公告)号：EP4095128A1
公开(公告)日：2022-11-30
申请号：EP21305676.5
申请日：2021-05-25
申请人： Centre national de la recherche scientifique , Commissariat à l'énergie atomique et aux énergies alternatives , Centre Hospitalier Universitaire Grenoble Alpes , Institut national de la santé et de la recherche médicale (INSERM) , Université Grenoble Alpes
IPC分类号： C07D215/42 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07F7/08 , C07F11/00 , A61K31/47 , A61P35/00
摘要： The present invention relates to new tetrahydroquinoline (THQ) compounds and new methods for synthetizing such compounds.
The THQs are inhibitors of BET proteins (Bromodomain and Extra Terminal Domain) such as BRD4 and are useful in therapeutic treatment of cancer or inflammation.
The present invention relates in particular to compound having the following structure :
wherein R, R', R A , Nu, R1, R2, R3, and R4 are each independently an atom or a chemical group of atoms-
公开(公告)号：EP4347567A1
公开(公告)日：2024-04-10
申请号：EP22730456.5
申请日：2022-05-24
申请人： Centre National de la Recherche Scientifique , Commissariat à l'énergie atomique et aux énergies alternatives , Centre Hospitalier Universitaire Grenoble Alpes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université Grenoble Alpes
IPC分类号： C07D215/42 , C07D215/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07F7/08 , C07F11/00 , A61K31/47 , A61P35/00
-
公开(公告)号：EP3406731A1
公开(公告)日：2018-11-28
申请号：EP17305596.3
申请日：2017-05-22
申请人： Commissariat à l'Energie Atomique et aux Energies Alternatives , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
CPC分类号： G01N33/582 , C12Q1/04 , C12Q1/16
摘要： The present invention provides a new method for the specific metabolic labeling of bacterial teichoic acids cell wall by modified choline and click chemistry, and its use in various applications such as bio-imaging, diagnostic, vaccination or bio-materials engineering.
-
8.发明公开NOUVEAUX DERIVES D'AZACOUMARINES PRESENTANT UNE ACTIVITE INHIBITRICE DES POMPES MDR 审中-公开WITH A MDR泵抑制剂作用的新AZACOUMARINDERIVATE
公开(公告)号：EP2668164A1
公开(公告)日：2013-12-04
申请号：EP12706636.3
申请日：2012-01-27
申请人： Université Claude Bernard Lyon I , Hospices Civils de Lyon , Centre National de la Recherche Scientifique (CNRS) , Université Joseph Fourier
发明人： DOLEANS-JORDHEIM, Anne , FRENEY, Jean , DUMONTET, Charles , BOUMENDJEL, Ahcène , VERON, Jean-Baptiste , WONG, Yung-Sing
IPC分类号： C07D215/06 , A61K31/404
CPC分类号： A61K31/4704 , A61K31/395 , A61K31/431 , A61K31/4709 , A61K31/473 , A61K31/496 , A61K31/5383 , A61K31/65 , A61K31/7048 , A61K38/14 , A61K45/06 , C07D215/06 , C07D215/58 , C07D401/04 , C07D409/04 , C12Q1/025 , A61K2300/00
摘要： The present invention relates to compounds of formula (I), where R1 and R2, identical or different, are each independently a hydrogen atom or a non-substituted or substituted (C1-C12) alkyl group; R3 is a hydrogen atom or a non-substituted or substituted (C1-C6) alkyl group; R4 is a non-substituted or substituted (C1-C12) alkyl group or an aryl or heteroaryl group, said aryl and heteroaryl groups being non-substituted or substituted; and R5 is a non-substituted or substituted (C1-C12) alkyl group; or R4 and R5 are bonded to one another by a saturated hydrocarbon chain having 3 or 4 carbon atoms, optionally in hydrated form or in the form of a salt that is acceptable for being administered to animals or plants, for the use thereof as a potentiator of the effect of an antimicrobial agent or for the use thereof as an antimicrobial agent.
-
公开(公告)号：EP3322421A1
公开(公告)日：2018-05-23
申请号：EP16750383.8
申请日：2016-07-12
申请人： Centre National de la Recherche Scientifique (CNRS) , Commissariat à l'Énergie Atomique et aux Énergies Alternatives
发明人： WONG, Yung-Sing , PLE, Sophie , ATTREE, Ina , BARETTE, Caroline
IPC分类号： A61K31/49 , C07D401/14 , C07D249/04 , G01N33/543
CPC分类号： G01N33/543 , A61K31/11 , A61K31/165 , A61K31/191 , A61K31/197 , A61K31/352 , A61K31/444 , A61K31/47 , A61K31/4709 , A61P31/04 , C07D213/30 , C07D401/14
摘要： The invention relates to a method of identifying molecules which inhibit the virulence machinery of
Pseudomonas aeruginosa , to a device for identifying a molecule which inhibits the virulence machinery of
Pseudomonas aeruginosa , to novel compounds which inhibit the virulence machinery of
Pseudomonas aeruginosa , to compounds for use for preventing and/or treating a pathogenic infection caused by
Pseudomonas aeruginosa and also to pharmaceutical compositions for preventing and/or treating a pathogenic infection caused by
Pseudomonas aeruginosa .
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.023 秒)
