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1.发明授权2-(4-AMINO-1,2,5-OXADIAZOL-4-YL)-IMIDAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS 有权2-（4-氨基-1,2,5-恶二唑-4-基） - 咪唑化合物作为蛋白激酶抑制剂的
公开(公告)号：EP1660467B1
公开(公告)日：2011-12-07
申请号：EP04781796.0
申请日：2004-08-20
发明人： COME, Jon, H. , GREEN, Jeremy , MARHEFKA, Craig , HARBESON, Scott, L. , PHAM, Ly
IPC分类号： C07D417/14 , C07D417/04 , C07D413/14 , C07D413/04 , C07D271/10 , A61K31/4245 , A61P11/06 , A61P3/10 , A61P25/28 , A61P25/18 , A61P25/16 , A61P35/00 , A61P9/00 , A61P31/12 , A61P17/14
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. In certain embodiments, these compounds are effective as inhibitors of p70S6k, GSK- 3 and/or ROCK protein kinases. These compounds have the general formula I.
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公开(公告)号：EP2032562A2
公开(公告)日：2009-03-11
申请号：EP07794722.4
申请日：2007-05-10
发明人： GREEN, Jeremy , CAO, Jingrong , BANDARAGE, Upul , COME, Jon , MARHEFKA, Craig
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , A61P35/00 , A61K31/427
CPC分类号： C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders.
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公开(公告)号：EP1558607B1
公开(公告)日：2010-05-05
申请号：EP03781448.0
申请日：2003-10-30
发明人： CAO, Jingrong , GAO, Huai , GREEN, Jeremy , MARHEFKA, Craig
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , C07D409/14
CPC分类号： C07D417/14 , C07D409/04 , C07D409/14 , C07D417/04
摘要： The present invention relates to substitute thiazole and thiophene derivatives useful as inhibitors of rock and other protein kinaeses. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, including proliferative, cardiac and neurodegenerative diseases.
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公开(公告)号：EP1663211B1
公开(公告)日：2010-01-20
申请号：EP04780381.2
申请日：2004-08-06
发明人： ARNOST, Michael J. , BEMIS, Guy W. , DAVIES, Robert J. , FORSTER, Cornelia J. , GREY, Ronald, Jr. , LEDFORD, Brian , MARHEFKA, Craig , MESSERSMITH, David , PIERCE, Albert C. , SALITURO, Francesco , WANG, Jian , LEDEBOER, Mark W.
IPC分类号： A61K31/4196 , C07D249/14 , C07D403/12 , C07D403/04 , C07D401/14 , C07D401/04 , C07D401/12 , C07D417/04 , C07D409/04 , C07D407/12 , C07D413/14 , A61P35/00
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to aminotriazole compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP1663211A1
公开(公告)日：2006-06-07
申请号：EP04780381.2
申请日：2004-08-06
发明人： ARNOST, Michael J. , BEMIS, Guy W. , DAVIES, Robert J. , FORSTER, Cornelia J. , GREY, Ronald, Jr. , LEDFORD, Brian , MARHEFKA, Craig , MESSERSMITH, David , PIERCE, Albert C. , SALITURO, Francesco , WANG, Jian
IPC分类号： A61K31/4196 , C07D249/14 , C07D403/12 , C07D403/04 , C07D401/14 , C07D401/04 , C07D401/12 , C07D417/04 , C07D409/04 , C07D407/12 , C07D413/14 , A61P35/00
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to aminotriazole compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP1558607A1
公开(公告)日：2005-08-03
申请号：EP03781448.0
申请日：2003-10-30
发明人： CAO, Jingrong , GAO, Huai , GREEN, Jeremy , MARHEFKA, Craig
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , C07D409/14
CPC分类号： C07D417/14 , C07D409/04 , C07D409/14 , C07D417/04
摘要： The present invention relates to substitute thiazole and thiophene derivatives useful as inhibitors of rock and other protein kinaeses. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, including proliferative, cardiac and neurodegenerative diseases.
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公开(公告)号：EP2032562B1
公开(公告)日：2010-08-25
申请号：EP07794722.4
申请日：2007-05-10
发明人： GREEN, Jeremy , CAO, Jingrong , BANDARAGE, Upul , COME, Jon , MARHEFKA, Craig
IPC分类号： C07D409/04 , C07D417/04 , C07D417/14 , A61P35/00 , A61K31/427
CPC分类号： C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders.
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8.发明公开
公开(公告)号：EP1756108A2
公开(公告)日：2007-02-28
申请号：EP05767612.4
申请日：2005-04-04
发明人： GREEN, Jeremy , MILLER, Andrew , JIMENEZ, Juan-Miguel , MARHEFKA, Craig , CAO, Jingrong , COURT, John, J. , BANDARAGE, Upul, K. , GAO, Huai , NANTHAKUMAR, Suganthini
IPC分类号： C07D471/04 , A61K31/437 , A61P37/08 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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9.发明公开
公开(公告)号：EP1660467A2
公开(公告)日：2006-05-31
申请号：EP04781796.0
申请日：2004-08-20
发明人： COME, Jon, H. , GREEN, Jeremy , MARHEFKA, Craig , HARBESON, Scott, L. , PHAM, Ly
IPC分类号： C07D271/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. In certain embodiments, these compounds are effective as inhibitors of p70S6k, GSK- 3 and/or ROCK protein kinases. These compounds have the general formula I.
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