利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.034 秒)

    Aldolases, nucleic acids encoding them and methods for making and using them
    4.
    发明公开
    Aldolases, nucleic acids encoding them and methods for making and using them 审中-公开
    醛醇缩酶，编码它们的核酸以及制备和使用它们的方法

    公开(公告)号：EP2388316A2

    公开(公告)日：2011-11-23

    申请号：EP11167408.1

    申请日：2007-03-07

    申请人： Verenium Corporation

    发明人： Burke, Ellen ,  Hicks, Paula M. ,  Luginbuhl, Peter ,  Richardson, Toby ,  Weiner, David P. ,  Zhao, Lishan

    IPC分类号： C12N9/10 ,  C12N9/88 ,  C12N15/82

    CPC分类号： C12N9/88 ,  A01K2217/05 ,  A61K38/00 ,  C07K2317/92 ,  C12N9/1022 ,  C12N15/8243 ,  C12P17/10 ,  C12Y401/03016 ,  C12Y401/03017 ,  Y02E50/16 ,  Y02E50/17

    摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

    摘要翻译： 本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性（包括热稳定性和耐热活性），以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和 多肽。 根据本发明的多肽可以用于各种制药，农业和工业环境中。 在一些实施方案中，本发明提供了用于生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体诸如R的多肽和生物合成途径 ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，如R，R和S，R构型及其盐。

    Aldolases, nucleic acids encoding them and methods for making and using them
    6.
    发明公开
    Aldolases, nucleic acids encoding them and methods for making and using them 审中-公开
    Adolasen，核酸编码这些，以及它们的制备和使用处理

    公开(公告)号：EP2388316A3

    公开(公告)日：2012-03-14

    申请号：EP11167408.1

    申请日：2007-03-07

    申请人： Verenium Corporation

    发明人： Burke, Ellen ,  Hicks, Paula M. ,  Luginbuhl, Peter ,  Richardson, Toby ,  Weiner, David P. ,  Zhao, Lishan

    IPC分类号： C12N9/10 ,  C12N9/88 ,  C12N15/82

    CPC分类号： C12N9/88 ,  A01K2217/05 ,  A61K38/00 ,  C07K2317/92 ,  C12N9/1022 ,  C12N15/8243 ,  C12P17/10 ,  C12Y401/03016 ,  C12Y401/03017 ,  Y02E50/16 ,  Y02E50/17

    摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

    摘要翻译： 本发明涉及所述多肽具有醛缩酶活性，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，多核苷酸编码所述多肽的合成，以及制备和使用这些多核苷酸和多肽的方法。 在一些实施方案中，本发明涉及具有醛缩酶活性，以多肽，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，包括热电表和耐热活性，多核苷酸编码合成的酶，以及制备和使用这些多核苷酸和 多肽。 在与本发明雅舞蹈的多肽可以在多种药物，农业和工业环境中使用。 在一些实施方案中，本发明提供的多肽和生物合成途径也都在生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的有用：如R ，R和S，R莫纳甜，以及它们的盐，以及莫纳甜衍生物，：如R，R和S，R构型，和它们的盐的某些立体异构体。

    Isomerases, nucleic acids encoding them and methods for making and using them
    7.
    发明公开
    Isomerases, nucleic acids encoding them and methods for making and using them 审中-公开
    异构酶，编码它们的核酸，以及制备方法及其用途

    公开(公告)号：EP2706122A2

    公开(公告)日：2014-03-12

    申请号：EP13195575.9

    申请日：2008-12-22

    申请人： Verenium Corporation

    发明人： Weiner, David ,  Burke, Ellen ,  Bueno, Analia ,  Cuenca, Joslin ,  De Souza, Mervyn L. ,  Kollmann, Sherry ,  Luginbuhl, Peter

    IPC分类号： C12Q1/533 ,  C12N9/90 ,  C12N15/61 ,  A61K38/52 ,  A23K1/165 ,  A23G4/12

    CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

    摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the rearrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

    摘要翻译： 本发明涉及基因的反弹于酶，多核苷酸编码的酶，利用搜索多核苷酸和多肽，更具体的涉及具有异构酶活性的酶，例如，消旋酶活性，例如，氨基酸消旋酶活性，丙氨酸消旋酶活性，和/或差向异构酶活性， 和/或催化的原子的重新排列的分子内，催化一种异构体转化为另一种，催化的光学活性底物转化成一总状花序，其全部在光学上是不活动的，催化底物的相互转换对映异构体围绕催化的立体化学反转 在仅具有一个不对称中心基板的不对称碳原子，围绕催化的配置的立体化学反转在不对称碳原子中具有多于一个不对称中心的基底，和/或催化的氨基酸外消旋化。 因此，本发明提供的酶，组合物，方法用于制备药物组合物，医药中间体，抗生素，甜味剂，肽酶，肽类激素，燃料，燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂， 药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆，和洗涤剂包括以本发明在雅舞蹈的多肽或多核苷酸。