公开(公告)号：EP2434008A1

公开(公告)日：2012-03-28

申请号：EP11194671.1

申请日：2007-08-31

申请人： Verenium Corporation ,  BASF SE

发明人： Kerovuo, Janne Samuli ,  Haremza, Sylke ,  Koch, Oliver ,  Habicher, Tilo ,  Robertson, Dan ,  Desantis, Grace ,  Luginbuhl, Peter ,  McCann, Ryan

IPC分类号： C12N9/02 ,  C12N1/20 ,  C12N15/00 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/68 ,  C12P21/06 ,  C12P21/04 ,  A61K38/44 ,  C07H21/04 ,  C07K1/00

CPC分类号： C12N9/0061 ,  C12N15/09 ,  C12P5/00 ,  C12P7/00 ,  C12P19/00 ,  C12Y110/03002 ,  D21C5/005 ,  D21C9/005 ,  D21C9/1063

摘要： Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.

摘要翻译： 本文提供了分离的漆酶和编码它们的核酸。 还提供了漆酶反应的介质。 本文还提供了使用漆酶氧化木质素和其它酚类和芳族化合物的方法，例如在高温和pH条件下用于木浆的生物漂白和脱色，以促进漂白化学品的使用的显着减少，以及用于 处理纤维。

公开(公告)号：EP2327766A1

公开(公告)日：2011-06-01

申请号：EP10190397.9

申请日：2002-05-15

申请人： Verenium Corporation

发明人： Chaplin, Jennifer Ann ,  Weiner, David Paul ,  Milan, Aileen ,  Chi, Ellen ,  Short, Jay M ,  Madden, Mark ,  Burk, Mark ,  Robertson, Dan ,  Desantis, Grace

IPC分类号： C12N9/00 ,  C12N9/78 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C12P1/00 ,  C12P7/00 ,  C12P7/62 ,  C07K1/00

CPC分类号： C12P13/004 ,  C12N9/78 ,  C12P7/42 ,  C12P13/04 ,  C12P41/006

摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and methods of use therefore are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

公开(公告)号：EP2327765A1

公开(公告)日：2011-06-01

申请号：EP10189100.0

申请日：2002-05-15

申请人： Verenium Corporation

发明人： Chaplin, Jennifer Ann ,  Weiner, David Paul ,  Milan, Aileen ,  Chi, Ellen ,  Short, Jay M ,  Madden, Mark ,  Burk, Mark ,  Robertson, Dan ,  Desantis, Grace

IPC分类号： C12N9/00 ,  C12N9/78 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C12P1/00 ,  C12P7/00 ,  C12P7/62 ,  C07K1/00

CPC分类号： C12P13/004 ,  C12N9/78 ,  C12P7/42 ,  C12P13/04 ,  C12P41/006

摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and methods of use therefore are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 此外还提供了设计新的腈水解酶的方法和使用方法。 腈水解酶在提高的pH和温度下具有增加的活性和稳定性。

公开(公告)号：EP2319919A1

公开(公告)日：2011-05-11

申请号：EP10190401.9

申请日：2002-05-15

申请人： Verenium Corporation

发明人： Chaplin, Jennifer Ann ,  Weiner, David Paul ,  Milan, Aileen ,  Chi, Ellen ,  Short, Jay M ,  Madden, Mark ,  Burk, Mark ,  Robertson, Dan ,  Desantis, Grace

IPC分类号： C12N9/00 ,  C12N9/78 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C12P1/00 ,  C12P7/00 ,  C12P7/62 ,  C07K1/00

CPC分类号： C12P13/004 ,  C12N9/78 ,  C12P7/42 ,  C12P13/04 ,  C12P41/006

摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and methods of use therefore are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

公开(公告)号：EP2039762A2

公开(公告)日：2009-03-25

申请号：EP08075753.7

申请日：2002-05-15

申请人： Verenium Corporation

发明人： Desantis, Grace ,  Chaplin, Jennifer, Ann ,  Weiner, David, Paul ,  Milan, Aileen ,  Chi, Ellen ,  Short, Jay, M. ,  Madden, Mark ,  Burk, Mark ,  Robertson, Dan

IPC分类号： C12N9/00 ,  C12N9/78 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C12P1/00 ,  C12P7/00 ,  C12P7/62 ,  C07K1/00

CPC分类号： C12P13/004 ,  C12N9/78 ,  C12P7/42 ,  C12P13/04 ,  C12P41/006

摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition, methods of designing new nitrilases and methods of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 此外，还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

公开(公告)号：EP2548955A1

公开(公告)日：2013-01-23

申请号：EP12168129.0

申请日：2007-02-14

申请人： Verenium Corporation

发明人： Weiner, David ,  Hansen, Connie Jo ,  Hancock, Charles ,  Woodward, Thomas ,  Beaver, Scott W ,  Blum, David ,  Healey, Shaun ,  Varvak, Alexander ,  Todaro, Thomas ,  Hazlewood, Geoff ,  Chang, Kristine ,  Chang, Hwai ,  Desantis, Grace

IPC分类号： C12N9/24

CPC分类号： C12N9/248 ,  A23K10/12 ,  A23K20/163 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L31/00 ,  A23L31/10 ,  A23L33/125 ,  A23V2002/00 ,  C12N9/2405 ,  C12N9/2437 ,  C12N9/2482 ,  C12N9/2488 ,  C12N9/2494 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01008 ,  D06L4/40 ,  D06L4/70 ,  D21C3/003 ,  D21C9/10 ,  D21H17/005 ,  Y02E50/16

摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo- β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部β-1,4-木糖苷键或内切-β-1,4-葡聚糖酶键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。 因此，本发明提供了用于分解半纤维素的方法和工艺，半纤维素是植物细胞壁的主要成分，包括水解任何植物或木材或木材产品，木材废物，纸浆，纸制品中的半纤维素的方法和工艺，或者 废纸或副产品。 另外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。 木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

公开(公告)号：EP2548954A1

公开(公告)日：2013-01-23

申请号：EP12168120.9

申请日：2007-02-14

申请人： Verenium Corporation

发明人： Weiner, David ,  Hansen, Connie Jo ,  Hancock, Charles ,  Woodward, Thomas ,  Beaver, Scott W ,  Blum, David ,  Healey, Shaun ,  Varvak, Alexander ,  Todaro, Thomas ,  Hazlewood, Geoff ,  Chang, Kristine ,  Chang, Hwai ,  Desantis, Grace

IPC分类号： C12N9/24

CPC分类号： C12N9/248 ,  A23K10/12 ,  A23K20/163 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L31/00 ,  A23L31/10 ,  A23L33/125 ,  A23V2002/00 ,  C12N9/2405 ,  C12N9/2437 ,  C12N9/2482 ,  C12N9/2488 ,  C12N9/2494 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01008 ,  D06L4/40 ,  D06L4/70 ,  D21C3/003 ,  D21C9/10 ,  D21H17/005 ,  Y02E50/16

摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo- β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.

公开(公告)号：EP2039762A3

公开(公告)日：2009-07-29

申请号：EP08075753.7

申请日：2002-05-15

申请人： Verenium Corporation

发明人： Desantis, Grace ,  Chaplin, Jennifer, Ann ,  Weiner, David, Paul ,  Milan, Aileen ,  Chi, Ellen ,  Short, Jay, M. ,  Madden, Mark ,  Burk, Mark ,  Robertson, Dan

IPC分类号： C12N9/00 ,  C12N9/78 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C12P1/00 ,  C12P7/00 ,  C12P7/62 ,  C07K1/00

CPC分类号： C12P13/004 ,  C12N9/78 ,  C12P7/42 ,  C12P13/04 ,  C12P41/006

摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition, methods of designing new nitrilases and methods of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 此外，还提供了设计新的腈水解酶的方法及其使用方法。 腈水解酶在提高的pH和温度下具有增加的活性和稳定性。

公开(公告)号：EP2548956A1

公开(公告)日：2013-01-23

申请号：EP12168130.8

申请日：2007-02-14

申请人： Verenium Corporation

发明人： Weiner, David ,  Hansen, Connie Jo ,  Hancock, Charles ,  Woodward, Thomas ,  Beaver, Scott W ,  Blum, David ,  Healey, Shaun ,  Varvak, Alexander ,  Todaro, Thomas ,  Hazlewood, Geoff ,  Chang, Kristine ,  Chang, Hwai ,  Desantis, Grace

IPC分类号： C12N9/24

CPC分类号： C12N9/248 ,  A23K10/12 ,  A23K20/163 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L31/00 ,  A23L31/10 ,  A23L33/125 ,  A23V2002/00 ,  C12N9/2405 ,  C12N9/2437 ,  C12N9/2482 ,  C12N9/2488 ,  C12N9/2494 ,  C12P19/02 ,  C12P19/14 ,  C12Y302/01008 ,  D06L4/40 ,  D06L4/70 ,  D21C3/003 ,  D21C9/10 ,  D21H17/005 ,  Y02E50/16

摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo- β-1,4-glucanase linkages; and/or degrading a linear polysaccharide beta-1,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.

公开(公告)号：EP2327767A1

公开(公告)日：2011-06-01

申请号：EP10190399.5

申请日：2002-05-15

申请人： Verenium Corporation

发明人： Chaplin, Jennifer Ann ,  Weiner, David Paul ,  Milan, Aileen ,  Chi, Ellen ,  Short, Jay M ,  Madden, Mark ,  Burk, Mark ,  Robertson, Dan ,  Desantis, Grace

IPC分类号： C12N9/00 ,  C12N9/78 ,  C12N1/20 ,  C12N15/00 ,  C07H21/02 ,  C12P1/00 ,  C12P7/00 ,  C12P7/62 ,  C07K1/00

CPC分类号： C12P13/004 ,  C12N9/78 ,  C12P7/42 ,  C12P13/04 ,  C12P41/006

摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and methods of use therefore are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提​​供了设计新腈水解酶的方法和使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。