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    Aldolases, nucleic acids encoding them and methods for making and using them
    7.
    发明公开
    Aldolases, nucleic acids encoding them and methods for making and using them 审中-公开
    醛醇缩酶，编码它们的核酸以及制备和使用它们的方法

    公开(公告)号：EP2388316A2

    公开(公告)日：2011-11-23

    申请号：EP11167408.1

    申请日：2007-03-07

    申请人： Verenium Corporation

    发明人： Burke, Ellen ,  Hicks, Paula M. ,  Luginbuhl, Peter ,  Richardson, Toby ,  Weiner, David P. ,  Zhao, Lishan

    IPC分类号： C12N9/10 ,  C12N9/88 ,  C12N15/82

    CPC分类号： C12N9/88 ,  A01K2217/05 ,  A61K38/00 ,  C07K2317/92 ,  C12N9/1022 ,  C12N15/8243 ,  C12P17/10 ,  C12Y401/03016 ,  C12Y401/03017 ,  Y02E50/16 ,  Y02E50/17

    摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

    摘要翻译： 本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。 在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性（包括热稳定性和耐热活性），以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和 多肽。 根据本发明的多肽可以用于各种制药，农业和工业环境中。 在一些实施方案中，本发明提供了用于生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体诸如R的多肽和生物合成途径 ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，如R，R和S，R构型及其盐。

    Aldolases, nucleic acids encoding them and methods for making and using them
    10.
    发明公开
    Aldolases, nucleic acids encoding them and methods for making and using them 审中-公开
    Adolasen，核酸编码这些，以及它们的制备和使用处理

    公开(公告)号：EP2388316A3

    公开(公告)日：2012-03-14

    申请号：EP11167408.1

    申请日：2007-03-07

    申请人： Verenium Corporation

    发明人： Burke, Ellen ,  Hicks, Paula M. ,  Luginbuhl, Peter ,  Richardson, Toby ,  Weiner, David P. ,  Zhao, Lishan

    IPC分类号： C12N9/10 ,  C12N9/88 ,  C12N15/82

    CPC分类号： C12N9/88 ,  A01K2217/05 ,  A61K38/00 ,  C07K2317/92 ,  C12N9/1022 ,  C12N15/8243 ,  C12P17/10 ,  C12Y401/03016 ,  C12Y401/03017 ,  Y02E50/16 ,  Y02E50/17

    摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

    摘要翻译： 本发明涉及所述多肽具有醛缩酶活性，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，多核苷酸编码所述多肽的合成，以及制备和使用这些多核苷酸和多肽的方法。 在一些实施方案中，本发明涉及具有醛缩酶活性，以多肽，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，包括热电表和耐热活性，多核苷酸编码合成的酶，以及制备和使用这些多核苷酸和 多肽。 在与本发明雅舞蹈的多肽可以在多种药物，农业和工业环境中使用。 在一些实施方案中，本发明提供的多肽和生物合成途径也都在生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的有用：如R ，R和S，R莫纳甜，以及它们的盐，以及莫纳甜衍生物，：如R，R和S，R构型，和它们的盐的某些立体异构体。