专利检索 ap:("Wyeth") AND inv:"MORRIS, Koi Michele" 第 1 页

1.

发明公开
AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5- PHENYLIMIDAZOLONE COMPOUNDS AS ß-SECRETASE INHIBITORS 审中-公开
标题翻译：氨基-5- [取代的] -4-（二氟甲氧基）苯基] -5- PHENYLIMIDAZOLON化合物作为β-分泌缝边

公开(公告)号：EP2137161A1

公开(公告)日：2009-12-30

申请号：EP08727031.0

申请日：2008-03-20

申请人： Wyeth

发明人： MALAMAS, Michael Sotirios , ROBICHAUD, Albert Jean , PORTE, Alexander Michael , SOLVIBILE, William Ronald , MORRIS, Koi Michele , ANTANE, Schuyler Adam , KIM, Ji-ln , MCDEVITT, Robert Emmett

IPC分类号： C07D233/88

CPC分类号： C07D233/88

摘要： The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula (I) The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.

2.

发明公开
AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS 审中-公开
标题翻译： AZOLYLACYLGUANIDINES作为ß-分泌酶抑制剂

公开(公告)号：EP1848692A1

公开(公告)日：2007-10-31

申请号：EP06734596.7

申请日：2006-02-06

申请人： Wyeth

发明人： COLE, Derek Cecil , MANAS, Eric Steven , JENNINGS, Lee Dalton , LOVERING, Frank Eldridge , STOCK, Joseph Raymond , MOORE, William Jay , ELLINGBOE, John Watson , CONDON, Jeffrey Scott , SUKHDEO, Mohani Nirmala , ZHOU, Ping , WU, Junjun , MORRIS, Koi Michele

IPC分类号： C07D207/32 , C07D409/04 , C07D413/04 , C07D405/12 , C07D413/12 , C07D411/12 , C07D403/12 , C07D405/04 , C07D405/06 , C07D409/06 , A61P25/28

CPC分类号： C07D207/327 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/337 , C07D207/36 , C07D401/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/10 , C07D417/12

摘要： The present invention provides an azolylacylquanidine compound of formula (I). The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

摘要翻译： 本发明提供式（I）的偶氮甲酰基胍化合物。本发明还提供了用于抑制β-分泌酶（BACE）和治疗β-淀粉样蛋白沉积物和神经原纤维缠结的方法。