公开(公告)号：EP0944312A4

公开(公告)日：2002-06-12

申请号：EP97954120

申请日：1997-12-12

申请人： ZYMOGENETICS INC

发明人： GASPER SHIRLEY R ,  WEST ROBERT R ,  MARTINEZ THERESA ,  BAINDUR NAND ,  ROBBINS KIRK G ,  LABROO VIRENDER M ,  MCKERNAN PATRICIA A

IPC分类号： A61K31/216 ,  A61K31/22 ,  A61K31/366 ,  A61K31/381 ,  A61K31/404 ,  A61K31/405 ,  A61P19/08 ,  A61P19/10 ,  A61K31/365

CPC分类号： A61K31/405 ,  A61K31/22 ,  A61K31/366 ,  A61K31/404

公开(公告)号：EP0866710A4

公开(公告)日：2001-07-11

申请号：EP96936906

申请日：1996-10-23

申请人： ZYMOGENETICS INC ,  OSTEOSCREEN INC ,  UNIV TEXAS AT AUSTIN

发明人： PETRIE CHARLES ,  ORME MARK W ,  BAINDUR NAND ,  ROBBINS KIRK G ,  HARRIS SCOTT M ,  KONTOYIANNI MARIA ,  HURLEY LAURENCE H ,  KERWIN SEAN M ,  MUNDY GREGORY R

IPC分类号： C07D285/16 ,  A61K31/12 ,  A61K31/47 ,  A61K31/549 ,  A61K31/54 ,  A61K31/35 ,  A61K45/06 ,  A61P19/00

CPC分类号： A61K31/549 ,  A61K31/47

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 ANGSTROM , are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.

公开(公告)号：EP0973513A4

公开(公告)日：2003-03-19

申请号：EP97912787

申请日：1997-10-23

申请人： ZYMOGENETICS INC ,  OSTEOSCREEN INC ,  UNIV TEXAS

发明人： ORME MARK W ,  BAINDUR NAND ,  ROBBINS KIRK G ,  HARRIS SCOTT M ,  KONTOYIANNI MARIA ,  HURLEY LAURENCE H ,  KERWIN SEAN M ,  MUNDY GREGORY R ,  PETRIE CHARLES

IPC分类号： C07D239/74 ,  A61K31/00 ,  A61K31/136 ,  A61K31/192 ,  A61K31/196 ,  A61K31/215 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/428 ,  A61K31/437 ,  A61K31/44 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/502 ,  A61K31/517 ,  A61K31/53 ,  A61K31/535 ,  A61K31/5415 ,  A61K31/549 ,  A61K31/655 ,  A61P19/08 ,  A61P19/10 ,  C07C49/84 ,  C07C69/92 ,  C07C225/32 ,  C07C233/55 ,  C07C233/59 ,  C07C233/80 ,  C07C235/38 ,  C07C237/20 ,  C07C243/22 ,  C07C243/32 ,  C07C243/34 ,  C07C243/38 ,  C07C245/08 ,  C07C251/20 ,  C07C251/28 ,  C07C251/48 ,  C07C251/66 ,  C07C251/86 ,  C07C259/10 ,  C07C311/39 ,  C07C323/62 ,  C07C337/06 ,  C07D213/53 ,  C07D213/76 ,  C07D213/78 ,  C07D213/85 ,  C07D215/12 ,  C07D215/38 ,  C07D235/08 ,  C07D235/22 ,  C07D241/42 ,  C07D265/16 ,  C07D277/20 ,  C07D277/56 ,  C07D277/64 ,  C07D277/82 ,  C07D279/16 ,  C07D285/16 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D471/04 ,  C07D521/00 ,  A61K31/165 ,  A61K31/33 ,  A61K31/405 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425 ,  A61K31/505

CPC分类号： A61K31/655 ,  A61K31/196 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/53

摘要： Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 ANGSTROM , are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.