公开(公告)号：EP4041760A1

公开(公告)日：2022-08-17

申请号：EP20874677.6

申请日：2020-10-08

申请人： Zymeworks Inc. ,  Provincial Health Services Authority ,  UVic Industry Partnerships Inc.

发明人： VOLKERS, Gesa ,  FULLER, Megan ,  BOULANGER, Martin J. ,  DIXIT, Surjit Bhimarao ,  NELSON, Brad ,  SANCHES, Mario ,  LOVELESS, Bianca

IPC分类号： C07K14/715 ,  A61K35/12 ,  A61K35/17 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C07K14/705 ,  C07K19/00 ,  C12N1/21 ,  C12N15/12 ,  C12N15/27 ,  C12N15/62 ,  C12N15/63 ,  C12N15/85 ,  C12N5/078 ,  C12N5/10 ,  C12P21/02

公开(公告)号：EP4041893A1

公开(公告)日：2022-08-17

申请号：EP20873827.8

申请日：2020-10-08

申请人： Provincial Health Services Authority ,  UVIC Industry Partnerships Inc.

发明人： NELSON, Brad ,  FULLER, Megan ,  BOULANGER, Martin J.

IPC分类号： C12N15/62 ,  A61K35/12 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C07K14/715 ,  C07K19/00 ,  C12N15/12 ,  C12N15/85 ,  C12N5/078 ,  C12N5/10 ,  C12P21/02

公开(公告)号：EP4320168A1

公开(公告)日：2024-02-14

申请号：EP22783744.0

申请日：2022-04-07

申请人： Provincial Health Services Authority ,  UVIC Industry Partnerships Inc.

发明人： BOULANGER, Martin J. ,  NELSON, Brad ,  POWELL, Cameron ,  FULLER, Megan

IPC分类号： C07K19/00 ,  A61K35/14 ,  A61K38/19 ,  A61K38/20 ,  A61K38/28 ,  A61P35/00 ,  A61P37/04 ,  A61P37/06 ,  C07K14/535 ,  C07K14/705 ,  C07K14/715 ,  C12N5/07 ,  C12N5/10 ,  C12N15/27 ,  C12N15/62

公开(公告)号：EP2914634A1

公开(公告)日：2015-09-09

申请号：EP13851307.2

申请日：2013-10-31

申请人： Zymeworks Inc.

发明人： SPRETER VON KREUDENSTEIN, Thomas ,  DIXIT, Surjit Bhimarao ,  LARIO, Paula Irene ,  ESCOBAR-CABRERA, Eric ,  BOULANGER, Martin J. ,  SUITS, Michael D.L.

IPC分类号： C07K16/46 ,  A61K39/395 ,  G06F19/16 ,  C07K16/28

CPC分类号： C07K16/00 ,  C07K16/2887 ,  C07K16/32 ,  C07K2299/00 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2317/94 ,  G06F19/16

摘要： Disclosed are the atomic coordinates of compositions comprising Fc heterodimer proteins in crystalline form derived from high resolution x-ray diffraction. Further disclosed are systems and methods for using all or a portion of these atomic coordinates to identify and design improved Fc heterodimer proteins. Further disclosed are compositions comprising a mixture of (i) a solubilized Fc heterodimer protein and (ii) a mother liquor solution. The mother liquor solution comprises between 2% and 10% (v/v) ethylene glycol, between 10% and 25% (w/v) polyethylene glycol having an average molecular weight of between 2000 Daltons and 10000 Daltons, and between 0.05 M and 0.40 M ammonium iodide. Further disclosed are systems and methods of identifying a mutation which promotes heterodimeric Fc chain pair formation in which structure based modeling is performed to identify a candidate mutation to an Fc chain using all or a portion of the disclosed three-dimensional atomic coordinates.

公开(公告)号：EP2914634B1

公开(公告)日：2017-12-06

申请号：EP13851307.2

申请日：2013-10-31

申请人： Zymeworks Inc.

发明人： SPRETER VON KREUDENSTEIN, Thomas ,  DIXIT, Surjit Bhimarao ,  LARIO, Paula Irene ,  ESCOBAR-CABRERA, Eric ,  BOULANGER, Martin J. ,  SUITS, Michael D.L.

IPC分类号： C07K16/46 ,  A61K39/395 ,  G06F19/16 ,  C07K16/28

CPC分类号： C07K16/00 ,  C07K16/2887 ,  C07K16/32 ,  C07K2299/00 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2317/94 ,  G06F19/16