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1.发明公开
公开(公告)号：EP4041760A1
公开(公告)日：2022-08-17
申请号：EP20874677.6
申请日：2020-10-08
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公开(公告)号：EP2914634B1
公开(公告)日：2017-12-06
申请号：EP13851307.2
申请日：2013-10-31
申请人： Zymeworks Inc.
发明人： SPRETER VON KREUDENSTEIN, Thomas , DIXIT, Surjit Bhimarao , LARIO, Paula Irene , ESCOBAR-CABRERA, Eric , BOULANGER, Martin J. , SUITS, Michael D.L.
IPC分类号： C07K16/46 , A61K39/395 , G06F19/16 , C07K16/28
CPC分类号： C07K16/00 , C07K16/2887 , C07K16/32 , C07K2299/00 , C07K2317/524 , C07K2317/526 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , G06F19/16
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公开(公告)号：EP2635607B1
公开(公告)日：2019-09-04
申请号：EP11837370.3
申请日：2011-11-04
申请人： Zymeworks Inc.
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公开(公告)号：EP2681245B1
公开(公告)日：2018-05-09
申请号：EP12751893.4
申请日：2012-03-02
申请人： Zymeworks Inc.
IPC分类号： C07K19/00 , C07K14/47 , C07K14/485 , C07K14/605 , C07K14/76 , C07K16/00 , C07K16/18 , C07K16/30
CPC分类号： C07K14/765 , C07K14/47 , C07K14/4721 , C07K14/485 , C07K14/605 , C07K14/76 , C07K14/79 , C07K16/283 , C07K16/32 , C07K19/00 , C07K2317/622 , C07K2319/00 , C07K2319/31 , C12N9/6454 , C12Y304/21061
摘要： Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species.
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5.发明公开
公开(公告)号：EP2773671A1
公开(公告)日：2014-09-10
申请号：EP12845801.5
申请日：2012-11-02
申请人： Zymeworks, Inc.
发明人： SPRETER VON KREUDENSTEIN, Thomas , DIXIT, Surjit Bhimarao , ESCOBAR-CABRERA, Eric , POON, David Kai Yuen , LARIO, Paula Irene
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , A61P37/02
CPC分类号： C07K16/32 , C07K16/2887 , C07K16/46 , C07K16/468 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/94 , G06F19/12
摘要： The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g.CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.
摘要翻译： 提供的支架具有在各种结构域（例如CH 2和CH 3）中不对称的重链，以实现参与调节效应子功能的各种Fc受体之间的选择性，超过用天然同型二聚体（对称）Fc分子可实现的选择性，并且增加稳定性和 所得变体Fc异二聚体的纯度。 这些新型分子包含异质组分的复合物，旨在改变抗体的自然行为方式，并用于治疗。
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公开(公告)号：EP2847230B1
公开(公告)日：2020-08-12
申请号：EP13788302.1
申请日：2013-05-10
申请人： Zymeworks Inc.
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7.发明公开BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2 审中-公开GEGEN HER2 GERICHTETE BISPEZIFISCHE ANTIGENBINDENDE KONSTRUKTE
公开(公告)号：EP3074424A1
公开(公告)日：2016-10-05
申请号：EP14866161.4
申请日：2014-11-27
申请人： Zymeworks Inc.
发明人： WEISSER, Nina E. , NG, Gordon Yiu Kon , WICKMAN, Grant Raymond , DIXIT, Surjit Bhimarao , ESCOBAR-CABRERA, Eric , SANCHES, Mario
IPC分类号： C07K16/46 , A61K39/395 , A61K47/48 , A61P35/00 , C07K16/28 , C12N15/13 , C12N5/10 , C40B40/08
CPC分类号： C07K16/32 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57492
摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.
摘要翻译： 本文提供了特异性结合HER2的二互补位的抗原结合构建体。 双互补位抗原结合构建体包含结合HER2的ECD2的一个抗原结合部分，其结合HER2的ECD4的第二抗原结合部分和Fc。 至少一个抗原结合部分是scFv。 两性反应性抗原结合构建体可用于治疗癌症。
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8.发明公开HETEROMULTIMER CONSTRUCTS OF IMMUNOGLOBULIN HEAVY CHAINS WITH MUTATIONS IN THE FC DOMAIN 审中-公开HETEROMULTIMERKONSTRUKTE严重的免疫球蛋白在FC结构域的突变
公开(公告)号：EP2847230A1
公开(公告)日：2015-03-18
申请号：EP13788302.1
申请日：2013-05-10
申请人： Zymeworks, Inc.
发明人： SPRETER VON KREUDENSTEIN, Thomas , ESCOBAR-CABRERA, Eric , NG, Gordon YiuKon , DIXIT, Surjit Bhimarao , LARIO, Paula Irene , POON, David Kai Yuen
IPC分类号： C07K16/46 , A61K39/395 , A61P35/00 , A61P37/02 , C07K16/12 , C07K16/24 , C07K16/28 , C07K16/30
摘要： Provided herein are isolated heteromultimers comprising: at least one single domain antigen-binding construct attached to at least one monomer of a heterodimer Fc region; wherein the heterodimer Fc region comprises a variant CH3 domain comprising amino acid mutations that promote the formation of said heterodimer with stability comparable to that of a native Fc homodimer; and wherein said isolated heteromultimer is devoid of immunoglobulin light chains and optionally devoid of immunoglobulin CH1 region. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.
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公开(公告)号：EP2914634A1
公开(公告)日：2015-09-09
申请号：EP13851307.2
申请日：2013-10-31
申请人： Zymeworks Inc.
发明人： SPRETER VON KREUDENSTEIN, Thomas , DIXIT, Surjit Bhimarao , LARIO, Paula Irene , ESCOBAR-CABRERA, Eric , BOULANGER, Martin J. , SUITS, Michael D.L.
IPC分类号： C07K16/46 , A61K39/395 , G06F19/16 , C07K16/28
CPC分类号： C07K16/00 , C07K16/2887 , C07K16/32 , C07K2299/00 , C07K2317/524 , C07K2317/526 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , G06F19/16
摘要： Disclosed are the atomic coordinates of compositions comprising Fc heterodimer proteins in crystalline form derived from high resolution x-ray diffraction. Further disclosed are systems and methods for using all or a portion of these atomic coordinates to identify and design improved Fc heterodimer proteins. Further disclosed are compositions comprising a mixture of (i) a solubilized Fc heterodimer protein and (ii) a mother liquor solution. The mother liquor solution comprises between 2% and 10% (v/v) ethylene glycol, between 10% and 25% (w/v) polyethylene glycol having an average molecular weight of between 2000 Daltons and 10000 Daltons, and between 0.05 M and 0.40 M ammonium iodide. Further disclosed are systems and methods of identifying a mutation which promotes heterodimeric Fc chain pair formation in which structure based modeling is performed to identify a candidate mutation to an Fc chain using all or a portion of the disclosed three-dimensional atomic coordinates.
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10.发明公开
公开(公告)号：EP2635607A1
公开(公告)日：2013-09-11
申请号：EP11837370.3
申请日：2011-11-04
申请人： Zymeworks, Inc.
发明人： CABRERA, Eric Escobar , VON KREUDENSTEIN, Thomas Spreter , DIXIT, Surjit Bhimarao , LARIO, Paula Irene , POON, David Kai Yuen , D'ANGELO, Igor Edmondo Paolo
CPC分类号： C07K16/468 , C07K16/00 , C07K16/32 , C07K2317/30 , C07K2317/524 , C07K2317/526 , C07K2317/64
摘要： The provided scaffolds have heavy chains that are asymmetric in the various domains (e.g. CH2 and CH3) to accomplish selectivity between the various Fc receptors involved in modulating effector function, beyond those achievable with a natural homodimeric (symmetric) Fc molecule, and increased stability and purity of the resulting variant Fc heterodimers. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.
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