公开(公告)号：EP4041760A1

公开(公告)日：2022-08-17

申请号：EP20874677.6

申请日：2020-10-08

申请人： Zymeworks Inc. ,  Provincial Health Services Authority ,  UVic Industry Partnerships Inc.

发明人： VOLKERS, Gesa ,  FULLER, Megan ,  BOULANGER, Martin J. ,  DIXIT, Surjit Bhimarao ,  NELSON, Brad ,  SANCHES, Mario ,  LOVELESS, Bianca

IPC分类号： C07K14/715 ,  A61K35/12 ,  A61K35/17 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C07K14/705 ,  C07K19/00 ,  C12N1/21 ,  C12N15/12 ,  C12N15/27 ,  C12N15/62 ,  C12N15/63 ,  C12N15/85 ,  C12N5/078 ,  C12N5/10 ,  C12P21/02

公开(公告)号：EP4026850A1

公开(公告)日：2022-07-13

申请号：EP21214023.0

申请日：2015-05-29

申请人： Zymeworks Inc.

发明人： SANCHES, Mario ,  SPRETER VON KREUDENSTEIN, Thomas ,  UROSEV, Dunja ,  D'ANGELO, Igor Edmondo Paolo ,  TOM-YEW, Stacey A. L. ,  DIXIT, Surjit Bhimarao ,  CORPER, Adam Louis ,  CHOU, Yang-Chieh

IPC分类号： C07K16/46 ,  A61K39/395 ,  C07K16/36 ,  C07K16/28 ,  C07K16/32

摘要： The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain or fragment thereof. At least one of the heterodimers can comprise one or more amino acid modifications in the C Hl and/or C L domains, one or more amino acid modifications in the V H and/or V L domains, or a combination thereof. The modified amino acid(s) can be part of the interface between the light chain and heavy chain and are typically modified to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer typically preferentially pairs with the second light chain rather than first.

公开(公告)号：EP2906237B8

公开(公告)日：2020-08-19

申请号：EP13816831.5

申请日：2013-07-12

申请人： Zymeworks Inc.

发明人： DIXIT, Surjit, Bhimarao ,  D'ANGELO, Igor Edmondo, Paolo ,  SANCHES, Mario ,  NG, Gordon Yiu Kon

IPC分类号： C07K16/46 ,  C07K16/28 ,  A61K39/395 ,  C07K14/76

公开(公告)号：EP3359576A1

公开(公告)日：2018-08-15

申请号：EP16852954.3

申请日：2016-10-07

申请人： Zymeworks Inc.

发明人： UROSEV, Dunja ,  SANCHES, Mario ,  TOM-YEW, Stacey A.L. ,  PRESTA, Leonard G.

IPC分类号： C07K16/46 ,  A61K39/395 ,  C07K16/00 ,  C12N15/13 ,  C12N15/63 ,  C12P21/00

CPC分类号： C07K16/46 ,  C07K16/244 ,  C07K16/32 ,  C07K16/468 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C12N15/63 ,  C12P21/00

摘要： Provided herein are multispecific antigen-binding polypeptide constructs comprising at least two different heterodimers, each comprising a heavy chain and a light chain. At least one heterodimer comprises a Fab region comprising a lambda light chain and at least one heterodimer comprises a Fab region comprising a kappa light chain. One or more of the immunoglobulin heavy and light chains that form the antigen-binding polypeptide construct comprise amino acid modifications that promote correct pairing between the heavy and light chains to form the desired multispecific antigen-binding polypeptide construct. The amino acid modifications may be in the CH1 and/or CL domains, in the VH and/or VL domains, or a combination thereof.

公开(公告)号：EP2906237A2

公开(公告)日：2015-08-19

申请号：EP13816831.5

申请日：2013-07-12

申请人： Zymeworks, Inc.

发明人： DIXIT, Surjit, Bhimarao ,  D'ANGELO, Igor Edmondo, Paolo ,  SANCHES, Mario ,  NG, Gordon Yiu Kon

IPC分类号： A61K38/38

摘要： Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each polypeptide construct comprising at least one cargo polypeptide attached to a transporter polypeptide, said transporter polypeptides derived from a monomeric native protein such that said monomeric constructs associate to form the heteromultimer and said transporter polypeptides associate to form a quasi-native structure of the monomeric native protein or analog thereof. These therapeutically novel molecules encompass heteromultimers comprising constructs that function as scaffolds for the conjugation or fusion of therapeutic molecular entities (cargo polypeptides) resulting in the creation of bispecific or multivalent molecular species. Provided herein is a method for creation of bispecific or multivalent molecular species.

公开(公告)号：EP2906237B1

公开(公告)日：2020-04-15

申请号：EP13816831.5

申请日：2013-07-12

申请人： Zymeworks, Inc.

发明人： DIXIT, Surjit, Bhimarao ,  D'ANGELO, Igor Edmondo, Paolo ,  SANCHES, Mario ,  NG, Gordon Yiu Kon

IPC分类号： C07K16/46 ,  C07K16/28 ,  A61K39/395 ,  C07K14/76

公开(公告)号：EP3107938A1

公开(公告)日：2016-12-28

申请号：EP15799575.4

申请日：2015-05-29

申请人： Zymeworks, Inc.

发明人： SANCHES, Mario ,  SPRETER VON KREUDENSTEIN, Thomas ,  UROSEV, Dunja ,  D'ANGELO, Igor Edmondo Paolo ,  TOM-YEW, Stacey A. L. ,  DIXIT, Surgit Bhimarao ,  CORPER, Adam Louis ,  CHOU, Yang-Chieh

IPC分类号： C07K16/46 ,  A61K39/395 ,  C07K16/00 ,  C12N15/13

CPC分类号： C07K16/468 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/36 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain or fragment thereof. At least one of the heterodimers can comprise one or more amino acid modifications in the CH1 and/or CL domains, one or more amino acid modifications in the VH and/or VL domains, or a combination thereof. The modified amino acid(s) can be part of the interface between the light chain and heavy chain and are typically modified to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co-expressed in a cell, the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise, the heavy chain of the second heterodimer typically preferentially pairs with the second light chain rather than first.

公开(公告)号：EP3074424A1

公开(公告)日：2016-10-05

申请号：EP14866161.4

申请日：2014-11-27

申请人： Zymeworks Inc.

发明人： WEISSER, Nina E. ,  NG, Gordon Yiu Kon ,  WICKMAN, Grant Raymond ,  DIXIT, Surjit Bhimarao ,  ESCOBAR-CABRERA, Eric ,  SANCHES, Mario

IPC分类号： C07K16/46 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K16/28 ,  C12N15/13 ,  C12N5/10 ,  C40B40/08

CPC分类号： C07K16/32 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492

摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.

摘要翻译： 本文提供了特异性结合HER2的二互补位的抗原结合构建体。 双互补位抗原结合构建体包含结合HER2的ECD2的一个抗原结合部分，其结合HER2的ECD4的第二抗原结合部分和Fc。 至少一个抗原结合部分是scFv。 两性反应性抗原结合构建体可用于治疗癌症。