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公开(公告)号：EP2041176A1
公开(公告)日：2009-04-01
申请号：EP07748263.6
申请日：2007-06-20
发明人： COCHRANE, Duncan , DUFNER, Patrick , LANGHAM, Caroline , NEEDHAM, Maurice , RUSSELL, Caroline , SLEEMAN, Matthew , WELSH, Fraser
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K14/54 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： Binding members, especially antibody molecules, for interleukin 17 (IL-17). The binding members are useful for the treatment of disorders associated with interleukin 17 such as rheumatoid arthritis.
摘要翻译： 用于白细胞介素17（IL-17）的结合成员，特别是抗体分子。 结合成员可用于治疗与白细胞介素17相关的疾病如类风湿性关节炎。
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2.发明公开
公开(公告)号：EP1922330A1
公开(公告)日：2008-05-21
申请号：EP06779398.4
申请日：2006-09-12
发明人： HARDING, Fiona Anne
CPC分类号： C07K14/21 , A61K47/642 , A61K47/6829 , C07K2319/33
摘要： The present invention provides PE CD4+ T-cell epitopes, as well as novel variants that exhibit reduced immunogenic responses, as compared to the parental PE. The present invention further provides DNA molecules that encode novel PE variants, host cells comprising DNA encoding novel PE variants, as well as methods for making PEs less immunogenic. In addition, the present invention provides various compositions that comprise these PE variants that are less immunogenic than wild-type PEs.
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3.发明公开RIBOSOME DISPLAY OR MRNA DISPLAY METHOD WITH SELECTION FOR INCREASED STABILITY OF THE PROTEIN 有权与选区RIBOSOMENPRÄSENTATIONS-和mRNA呈现过程对于蛋白质的稳定性增加
公开(公告)号：EP1833965A1
公开(公告)日：2007-09-19
申请号：EP06700177.6
申请日：2006-01-05
发明人： BUCHANAN, Andrew Cambridge Antibody Technology Ltd , JERMUTUS, Lutz, Cambridge Antibody Technology Ltd.
IPC分类号： C12N15/10
CPC分类号： C12N15/1062 , C12N15/1041
摘要： A method of providing a subject polypeptide variant with improved stability compared with a parent subject polypeptide, employing translation and selection using an RNA expression system, wherein two or more stability selection pressures are applied simultaneously during translation, two or more stability selection pressures are applied simultaneously during selecting, or at least one stability selection pressure is applied during translation and continues to be applied during selecting, and at least one further stability selection pressure is applied during selecting.
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公开(公告)号：EP1268766B1
公开(公告)日：2005-11-30
申请号：EP01914058.1
申请日：2001-03-26
发明人： OSBOURN, Jane, Cambridge Antibody Technology Ltd , HOLET, Thor, Cambridge Antibody Technology Limited
CPC分类号： C12N15/1034 , C07K16/00 , C07K16/28 , C07K16/44 , C07K2317/622 , C12N15/1041
摘要： The use in a ribosome display system for a selection of a specific binding pair member (e.g. antibody molecule) able to bind a complementary specific binding pair member (e.g. antigen) of encapsidating specific binding member/ribosome complexes ina viral coat, optionally in combination with incorporation of an Midvariant RNA template and optionally one or more other improvements selected from : glycine-serine tether, protein disulphide isomerase, protein disulphide isomerase in combination with oxidised and reduced glutathione at a ratio of between 1:1 and 10:1, addition of oxidised and reduced glutathione at a ratio of between 1:1 and 10:1 after 30 minutes of in vitro translation; blocking with heparin during selection.
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公开(公告)号：EP1242458A2
公开(公告)日：2002-09-25
申请号：EP00979747.3
申请日：2000-11-27
发明人： WEBSTER, Carl , OSBOURN, Jane , WARD, George , MILLER, Karen
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to specific binding members directed to the brain, including specific binding members able to pass through the blood brain barrier or which are directed to areas of brain inflammation or blood brain barrier breakdown. Panels and mixtures of antibodies are provided, also individual antibody molecules and VH and VL domains, along with methods of obtaining specific binding members by selection, e.g. using libraries displayed on the surface of filamentous bacteriophage.
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公开(公告)号：EP1175445A1
公开(公告)日：2002-01-30
申请号：EP00927483.8
申请日：2000-05-02
发明人： THOMPSON, Julia, Elizabeth , LENNARD, Simon, Nicholas , WILTON, Alison, Jane , BRADDOCK, Peta, Sally, Helena , DU FOU, Sarah, Leila , MCCAFFERTY, John, Gerald , CONROY, Louise, Anne , TEMPEST, Philip, Ronald
IPC分类号： C07K16/22 , A61K39/395 , G01N33/577 , A61P35/00 , A61P13/12 , A61P27/02 , A61P37/00 , A61P11/06
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/622
摘要： The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralising activity for TGFβ1 and are useful in treating conditions associated with excess TGFβ1 activity, such as fibrosis, immune responses and tumour progression.
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7.发明授权METHODS FOR PRODUCING FUNCTIONAL, SINGLE-CHAIN Fv ANTIBODY FRAGMENTS ON THE SURFACE OF BACTERIOPHAGE PARTICLES 失效METHOD FOR产生功能性，单链Fv抗体片段噬菌体ON SURFACES
公开(公告)号：EP0589877B1
公开(公告)日：1996-11-13
申请号：EP91913039.3
申请日：1991-07-10
发明人： McCAFFERTY, John , POPE, Anthony, Richard , JOHNSON, Kevin Stuart , HOOGENBOOM, Hendricus Renerus Jacobus Mattheus , GRIFFITHS, Andrew David , JACKSON, Ronald, Henry , HOLLIGER, Kaspar, Philipp , MARKS, James David , CLACKSON, Timothy, Piers , CHISWELL, David John , WINTER, Gregory, Paul , BONNERT, Timothy, Peter
IPC分类号： C12N7/01 , C07K1/04 , G01N33/531
CPC分类号： C07K16/005 , B01J2219/00718 , C07K16/00 , C07K16/18 , C07K16/26 , C07K16/34 , C07K16/40 , C07K16/44 , C07K16/462 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/62 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/41 , C07K2319/735 , C12N15/1037 , C12N15/62 , C12N15/73 , C40B40/02 , G01N33/53 , G01N33/6857 , Y10S530/867
摘要： A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods.
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公开(公告)号：EP1847605A3
公开(公告)日：2007-10-31
申请号：EP07006223.7
申请日：1991-07-10
发明人： McCafferty, John , Pope, Anthony Richard , Johnson, Kevin Stuart , Hoogenboom, Hendricus Renerus Jacobus Mattheus , Griffiths, Andrew David , Jackson, Ronald Henry , Holliger, Kaspar Philipp , Marks, James David , Clackson, Timothy Piers , Chiswell, David John , Winter, Gregory Paul , Bonnert, Timothy Peter
CPC分类号： C07K16/005 , B01J2219/00718 , C07K16/00 , C07K16/18 , C07K16/26 , C07K16/34 , C07K16/40 , C07K16/44 , C07K16/462 , C07K16/468 , C07K19/00 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/62 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/41 , C07K2319/735 , C12N15/1037 , C12N15/62 , C12N15/73 , C40B40/02 , G01N33/53 , G01N33/6857 , Y10S530/867
摘要： A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding the sbp member or a polypeptide component thereof, by virtue of the sbp member or a polypeptide component thereof being expressed as a fusion with a capsid component of the rgdp. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected rgdps for expression of the selected sbp members. Antibody sbp members may be thus obtained, with the different chains thereof expressed, one fused to the capsid component and the other in free form for association with the fusion partner polypeptide. A phagemid may be used as an expression vector, with said capsid fusion helping to package the phagemid DNA. Using this method libraries of DNA encoding respective chains of such multimeric sbp members may be combined, thereby obtaining a much greater genetic diversity in the sbp members than could easily be obtained by conventional methods.
摘要翻译： 特定结合对（sbp）的成员通过在重组宿主细胞中表达编码这种sbp成员的基因多样性群体的DNA来鉴定，其中sbp成员以功能形式显示在分泌的重组遗传展示包（rgdp ）含有编码sbp成员的DNA或其多肽组分，因为sbp成员或其多肽组分与rgdp的衣壳组分表达融合。 显示的sbps可以通过与互补sbp成员的亲和力来选择，并且从选择的rgdps恢复的DNA用于表达选定的sbp成员。 因此可以获得抗体sbp成员，其不同的链表达，一个融合至衣壳组分，另一个以游离形式与融合伴侣多肽结合。 噬菌粒可用作表达载体，所述衣壳融合有助于包装噬菌粒DNA。 使用这种方法，可以将编码这种多聚体sbp成员各自链的DNA文库组合起来，从而在sbp成员中获得比通过常规方法容易获得的更大的遗传多样性。
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公开(公告)号：EP1846451A1
公开(公告)日：2007-10-24
申请号：EP06701099.1
申请日：2006-01-24
发明人： FRANKS, Ruth, Cambridge Antibody Technology Limited , BUCHANAN, Andrew Grier, Cambridge Antibody Technology Limited , THOM, Albert George, Cambridge Antibody Technology Limited , WELSH, Fraser Ewing, Cambridge Antibody Technology Limited , BLAND-WARD, Philip Antony, Cambridge Antibody Technology Limited , SLEEMAN, Matthew Alexander, Cambridge Antibody Technology Limited , MATTHEWS, Carl Anthony, Cambridge Antibody Technology Limited , HART, Celia Patricia, Cambridge Antibody Technology Limited , HAWKINSON, Jon, Elan Pharmaceuticals, Inc.
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K14/48 , C07K2317/21 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those that neutralise NGF activity. Methods for using anti-NGF antibody molecules in diagnosis or treatment of NGF related disorders, including pain, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, other diseases of airway inflammation, diabetic neuropathy, cardiac arrhythmias, HIV, arthritis, psoriasis and cancer.
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公开(公告)号：EP1651754B1
公开(公告)日：2007-04-11
申请号：EP04743600.1
申请日：2004-07-28
CPC分类号： C12N5/0694 , C12N5/0037 , C12N5/005 , C12N2500/24 , C12N2500/90 , C12N2500/95 , C12N2510/02
摘要： The present invention relates to a method for culturing mammalian cells in a culture medium which is transferrin free and which contains no lipophilic or synthetic nitrogen-containing chelators. Also provided is the use of the medium and a process for providing a mammalian product by culturing cells capable of producing the product in the medium.
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