PROCESS FOR PRODUCING 3-CHLOROMETHYL-3-CEPHEM DERIVATIVE
    9.
    发明公开
    PROCESS FOR PRODUCING 3-CHLOROMETHYL-3-CEPHEM DERIVATIVE 有权
    用于生产3-氯甲基-3-头孢

    公开(公告)号:EP1666483A4

    公开(公告)日:2008-12-03

    申请号:EP04787629

    申请日:2004-09-06

    IPC分类号: C07D501/24 C07D501/10

    CPC分类号: C07D501/10 C07D501/24

    摘要: An industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process for 3-chloromethyl-3-cephem derivative production comprises: a first step in which a thiazolineazetidinone derivative (1) is reacted with a sulfonyl halide (2) in the presence of an acid in a solvent to obtain an azetidinone derivative (3); a second step in which the azetidinone derivative (3) is reacted with a chlorinating agent in an organic solvent to obtain a chlorinated azetidinone derivative (4); and a third step in which the chlorinated azetidinone derivative (4) is reacted with an alcoholate (5) at a pH of 8 or lower in a solvent comprising an alcohol and an ether and a 3-chloromethyl-3-cephem derivative (6) is recovered in the form of crystals.