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公开(公告)号：EP2316846B1
公开(公告)日：2019-10-02
申请号：EP10011035.2
申请日：2004-08-02
发明人： Deslongchamps, Pierre , Dory, Yves , Benakli, Kamel , Marsault, Eric , Ouellet, Luc , Vézina, Martin , Fortin, Daniel , Lan, Ruoxi , Li, Shigui , Villeneuve, Gérald , Beaubien, Sylvie , Peterson, Mark L. , Ramaseshan, Mahesh , Hoveyda, Hamid R.
IPC分类号： C07K5/00 , C07K5/08 , C07K1/04 , C07K5/12 , C07D263/32 , C07D277/24 , C07D277/28 , C07K5/087 , C07K5/083 , C07K5/097
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公开(公告)号：EP3373923A1
公开(公告)日：2018-09-19
申请号：EP16865158.6
申请日：2016-11-11
发明人： WANG, Laurene , GRAIS, Linda S. , BUKOFZER, Stan
IPC分类号： A61K31/198 , A61K31/192 , A61K31/195 , C07C57/32 , A61K9/00 , A61P3/00 , A61P1/16
CPC分类号： A61K9/5078 , A61K9/5031 , A61K9/5042 , A61K31/198
摘要： Some embodiments of the present application are directed to oral formulations of L- ornithine phenylacetate and methods of using the same. These oral formulations offer alternative administration route than the standard intravenous administration of L-ornithine phenylacetate for treating hyperammonemia in patients having various acute and chronic liver diseases and disorders, for example, acute liver failure, liver cirrhosis, liver decompensation, portal hypertension, hepatic encephalopathy, or patients with urea cycle disorders.
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3.发明公开
公开(公告)号：EP3337473A1
公开(公告)日：2018-06-27
申请号：EP16837708.3
申请日：2016-08-16
IPC分类号： A61K31/192 , A61K31/198 , A61P1/16
CPC分类号： A61K31/198 , A61K9/0019 , A61K31/192 , A61K2300/00 , A61P1/16 , C12Q1/42 , C12Q1/48 , G01N2800/085
摘要： Disclosed herein are methods of treating and preventing muscle loss using ornithine in combination with at least one of phenyl acetate and phenylbutyrate.
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4.发明公开USE OF ADSORBENT CARBON MICROSPHERES FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME 审中-公开使用吸附碳微若要可爱易激综合症的治疗
公开(公告)号：EP1957090A1
公开(公告)日：2008-08-20
申请号：EP06839125.9
申请日：2006-12-05
发明人： SHIBATA, Akiko , FISCHER, Laurent
摘要： Adsorbent carbon microspheres are administered to treat irritable bowel syndrome or symptoms associated with irritable bowel syndrome.
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公开(公告)号：EP3517110A1
公开(公告)日：2019-07-31
申请号：EP19158338.4
申请日：2010-06-08
发明人： JALAN, Rajiv , ANDERSON, Keith
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P29/00
摘要： Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-omithine phenylacetate.
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公开(公告)号：EP2799067B1
公开(公告)日：2019-04-03
申请号：EP14175859.9
申请日：2010-06-08
发明人： Jalan, Rajiv , Anderson, Keith
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P9/12 , A61P1/16
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公开(公告)号：EP3263100A1
公开(公告)日：2018-01-03
申请号：EP17185173.6
申请日：2010-04-01
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine Henderson , WATT, Stephen William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46 , C07C57/32
摘要： Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
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公开(公告)号：EP2625162A1
公开(公告)日：2013-08-14
申请号：EP11831546.4
申请日：2011-10-05
发明人： ANDERSON, Keith, H. , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
IPC分类号： C07C227/18 , C07C229/26 , C07C57/46 , A61K31/198 , A61K31/192 , A61P1/16
CPC分类号： C07C227/18 , A61K31/192 , A61K31/198 , C07C51/412 , C07C229/26 , C07C57/32
摘要： Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, inter-mixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms.
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公开(公告)号：EP3285756B1
公开(公告)日：2023-02-22
申请号：EP16783692.3
申请日：2016-04-19
IPC分类号： A61K31/195 , A61K31/192 , A61P1/16 , A61K9/08
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公开(公告)号：EP2625162B1
公开(公告)日：2019-03-13
申请号：EP11831546.4
申请日：2011-10-05
发明人： ANDERSON, Keith, H. , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
IPC分类号： C07C51/41 , C07C227/18 , C07C229/26 , C07C57/46 , A61K31/198 , A61K31/192 , A61P1/16
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