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1.发明公开LIPID-COMPRISING DRUG DELIVERY COMPLEXES AND METHODS FOR THEIR PRODUCTION 审中-公开脂质含药物供应COMPLEX及其制造方法
公开(公告)号：EP1383480A4
公开(公告)日：2006-05-24
申请号：EP02725861
申请日：2002-04-30
发明人： HARVIE PIERROT , PAUL RALPH , CUDMORE SALLY , O'MAHONY DANIEL J
IPC分类号： C12N15/09 , A61K9/127 , A61K47/22 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/42 , A61K47/46 , A61K47/48 , A61K48/00 , A61P29/00 , A61P43/00 , C07K5/09 , C07K7/08 , C07K9/00 , C07K14/025 , C07K14/59 , C07K14/62 , C12N15/88 , C12N15/00 , C12N15/63
CPC分类号： C12N15/88 , A61K9/1272 , A61K47/58 , A61K47/60 , A61K48/0025 , C12N2810/40 , C12N2810/405 , C12N2810/854
摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The complexes of the invention comprise a drug, at least one lipid species, optionally at least one polycation, and at least one targeting factor. The at least one lipid species may comprise a pegylated lipid. The complexes of the invention may provoke lower levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α). The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.
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2.发明公开HYBRID GENES FOR USE IN THE PRODUCTION OF T H?-INDEPENDENT CYTOTOXIC T CELLS 失效杂合基因FOR USE IN辅助T细胞非依赖性细胞毒性T细胞的制备
公开(公告)号：EP0693940A4
公开(公告)日：1998-08-19
申请号：EP94914020
申请日：1994-04-04
IPC分类号： C12N15/09 , A61K38/00 , C07H21/04 , C07K14/525 , C07K14/54 , C07K14/55 , C07K14/57 , C07K14/705 , C12N1/21 , C12N5/10 , C12N15/19 , C12N15/23 , C12N15/24 , C12N15/27 , C12N15/85 , A61K48/00 , C12N15/63
CPC分类号： C12N15/85 , A61K38/00 , C07K14/5255 , C07K14/5403 , C07K14/55 , C07K14/57 , C07K14/70521 , C12N2830/00 , C12N2830/85
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公开(公告)号：EP0733103A4
公开(公告)日：1997-12-17
申请号：EP95902421
申请日：1994-11-03
IPC分类号： C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P1/18 , A61P3/12 , A61P7/06 , A61P11/00 , A61P43/00 , C12N5/10 , C12N7/00 , C12N15/864 , C12N7/01 , C12N15/10 , C12N15/48 , C12N15/86
CPC分类号： C12N15/86 , C12N2750/14143
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4.发明公开STABLE CELL LINES CAPABLE OF EXPRESSING THE ADENO-ASSOCIATED VIRUS REPLICATION GENE 失效稳定的细胞系，将能够给复制基因ADENOASSOZIERTENVIRUS来表达
公开(公告)号：EP0728214A4
公开(公告)日：1997-02-12
申请号：EP95900505
申请日：1994-11-03
发明人： TREMPE JAMES P , YANG QICHENG
IPC分类号： C12N15/09 , C07K14/015 , C12N5/00 , C12N5/10 , C12N7/04 , C12N15/63 , C12N15/86 , C12N15/864 , C12P21/02 , C12R1/91
CPC分类号： C12N15/86 , C12N2750/14143
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