公开(公告)号：EP3198038A4

公开(公告)日：2018-06-20

申请号：EP15843730

申请日：2015-09-22

申请人： UNIV ROCKEFELLER ,  RENSSELAER POLYTECH INST

发明人： STANLEY SARAH ,  FRIEDMAN JEFFREY ,  DORDICK JONATHAN S ,  SAUER JEREMY

IPC分类号： C12Q1/68 ,  G01N33/68

CPC分类号： G01N33/6872 ,  A61K48/00 ,  A61K48/005 ,  A61N2/00 ,  A61N2/004 ,  A61N5/025 ,  C07K14/705 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2800/30 ,  G01N33/5005 ,  G01N2800/042

摘要： The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.

公开(公告)号：EP3164146A4

公开(公告)日：2018-03-21

申请号：EP15812120

申请日：2015-06-26

申请人： UNIV ROCKEFELLER

发明人： FISCHETTI VINCENT ,  SCHUCH RAYMOND ,  LOOD ROLF ,  WINER BENJAMIN

IPC分类号： A61K35/76 ,  A61K38/46

CPC分类号： C12N9/2402 ,  A61K9/0014 ,  A61K9/0019 ,  A61K38/00 ,  A61K38/162 ,  A61K38/47 ,  A61K47/48246 ,  A61K47/64 ,  A61L2/16 ,  A61L29/043 ,  A61L29/085 ,  A61L29/16 ,  A61L2202/24 ,  A61L2300/254 ,  A61L2300/406 ,  C07K2319/00 ,  C12N9/88 ,  C12N9/96

摘要： Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using Acinetobacter lysin polypeptides.

公开(公告)号：EP3074050A4

公开(公告)日：2017-11-29

申请号：EP14857152

申请日：2014-10-28

申请人： ICAHN SCHOOL MED MOUNT SINAI ,  UNIV ROCKEFELLER

发明人： SCHAEFER ANNE ,  GREENGARD PAUL

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61P25/08

CPC分类号： C12N15/113 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2217/052 ,  A01K2217/075 ,  A01K2217/203 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/185 ,  A61K49/0008 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515 ,  C12N2310/3521 ,  G01N33/5058

摘要： The invention is directed to compositions and methods for treating or reducing the likelihood of the development of epilepsy in an individual. The method comprises administering to the central nervous system of an individual in need of such treatment a therapeutically effective amount of an agent capable of increasing the expression and/or activity of miR-128.

公开(公告)号：EP2914344A4

公开(公告)日：2017-04-26

申请号：EP13851439

申请日：2013-10-31

申请人： UNIV ROCKEFELLER

发明人： TAVAZOIE SOHAIL ,  LOO JIA MIN

IPC分类号： A61P35/04 ,  A61K31/197 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/53

CPC分类号： A61K31/197 ,  A61K9/0019 ,  A61K31/337 ,  A61K31/4168 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/555 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7088 ,  A61K45/06

摘要： The present invention discloses novel agents and methods for diagnosis and treatment of colon cancer. Also disclosed are related arrays, kits, and screening methods.

摘要翻译： 本发明公开了诊断和治疗结肠癌的新药和方法。 还公开了相关的阵列，试剂盒和筛选方法。

公开(公告)号：EP2983693A4

公开(公告)日：2016-10-26

申请号：EP14782569

申请日：2014-04-07

申请人： UNIV CARMEL HAIFA ECONOMIC COR ,  UNIV ROCKEFELLER

发明人： LARISCH SARIT ,  STELLER HERMANN

IPC分类号： A61K38/17 ,  A61P1/16 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A61K31/185 ,  A61K31/53 ,  A61K38/17 ,  C12Q2600/118 ,  C12Q2600/154 ,  G01N33/57438 ,  G01N33/576 ,  G01N2800/08 ,  G01N2800/085 ,  G01N2800/52 ,  G01N2800/54

摘要： The invention relates to methods for the diagnosis and prognosis of hepatic disorder and associated pathologies as well as of a solid proliferative disorder in a mammalian subject. More specifically, the methods of the invention are based on determining the expression, methylation of ARTS as well as histone trimethylation. The invention further provides therapeutic methods for treating said disorders.

公开(公告)号：EP2934589A4

公开(公告)日：2016-08-10

申请号：EP13866337

申请日：2013-12-18

申请人： UNIV ROCKEFELLER

发明人： SONG RUIJIANG ,  HO DAVID D

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2812 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/76

摘要： Disclosed herein are glycan-modified anti-CD4 monoclonal antibodies with N-linked glycans attached to the variable region. Expression vectors and cell lines useful for the production of such antibodies, and use of such antibodies for HIV prevention and therapy are also disclosed.

摘要翻译： 本文公开了具有连接到可变区的N-连接聚糖的聚糖修饰的抗CD4单克隆抗体。 还公开了可用于产生这种抗体的表达载体和细胞系，以及这些抗体用于HIV预防和治疗的用途。

公开(公告)号：EP2793918A4

公开(公告)日：2015-11-18

申请号：EP12859843

申请日：2012-12-10

申请人： UNIV ROCKEFELLER ,  SLOAN KETTERING INST CANCER

发明人： RAVETCH JEFFREY V ,  PINCETIC ANDREW ,  WANG PING ,  DANISHEFSKY SAM

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/705 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K31/7028 ,  A61K38/00 ,  A61K38/16 ,  A61K38/1709 ,  A61K2039/505 ,  C07H7/02 ,  C07K14/47 ,  C07K14/705

摘要： Polypeptides that bind to DC-SIGN and/or its homologues and methods for using such peptides for the treatment of various disorders are described. DC-SIGN and its homologues are receptors that bind IgG antibodies or Fc fragments and mediate intravenous immunoglobulin (IVIG)-related reversal of inflammation associated with various immune disorders.

摘要翻译： 描述了结合DC-SIGN和/或其同源物的多肽和使用这些肽用于治疗各种疾病的方法。 DC-SIGN及其同源物是结合IgG抗体或Fc片段并介导与各种免疫疾病相关的炎症的静脉内免疫球蛋白（IVIG）相关逆转的受体。

公开(公告)号：EP2673363A4

公开(公告)日：2015-04-15

申请号：EP12745124

申请日：2012-02-10

申请人： UNIV ROCKEFELLER

发明人： TAVAZOIE SOHAIL ,  HALBERG NILS ,  PNG KIM

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K38/17 ,  C07H21/00

CPC分类号： C12Q1/6886 ,  A61K38/1709 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2300/00 ,  C07K16/18 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2320/12 ,  C12N2330/31 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/16 ,  C12Q2600/178

摘要： This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.

公开(公告)号：EP2656073A4

公开(公告)日：2014-12-17

申请号：EP11850401

申请日：2011-12-19

申请人： UNIV ROCKEFELLER

发明人： RAVETCH JEFFREY V ,  LI FUBIN

IPC分类号： G01N33/53 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  C07K16/28 ,  G01N33/68

CPC分类号： C07K16/2878 ,  A61K38/177 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2851 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/6863 ,  G01N2333/70535 ,  G01N2333/70578 ,  A61K31/00

摘要： The instant invention relates to agents (e.g., agonistic antibodies) able to stimulate the immune system of a mammalian animal and activate target-cell specific T lymphocyte responses. Such agents may be identified based on the ability to engage a receptor from the TNFR Superfamily and thereby mimic the natural ligand for the receptor from the TNFR Superfamily. Modified antibodies of this class display enhanced immunostimulatory activity and may be formulated and administered for the treatment of a disease or disorder.

摘要翻译： 本发明涉及能够刺激哺乳动物的免疫系统并激活靶细胞特异性T淋巴细胞应答的药剂（例如，激动性抗体）。 可以基于从TNFR超家族中接合受体的能力鉴定出这些药剂，从而从TNFR超家族模拟受体的天然配体。 该类的修饰抗体显示增强的免疫刺激活性，并且可以配制和施用以治疗疾病或病症。

公开(公告)号：EP1833489A4

公开(公告)日：2011-08-03

申请号：EP05857215

申请日：2005-12-27

申请人： UNIV ROCKEFELLER ,  SCRIPPS RESEARCH INST

发明人： WONG CHI-HUEY ,  WU DOUG ,  FUJIO MASAKAZU ,  TSUJI MORIYA ,  HO DAVID

IPC分类号： A61K31/70 ,  C07H15/00

CPC分类号： C07H15/06 ,  C07H15/00 ,  C07H15/18 ,  C07H15/26