GLUCAN GELS
    3.
    发明公开

    公开(公告)号:EP2646476A1

    公开(公告)日:2013-10-09

    申请号:EP11796784.4

    申请日:2011-11-29

    IPC分类号: C08B37/00 C08J3/075 A61K31/00

    摘要: The present invention relates to a glucan having a weight average molar mass of 15,000 to 50,000 g/mol on a single chain basis and a weight average molar mass in aqueous solution on an aggregate basis of 4 to 20×105 g/mol and existing in gel form in aqueous solution at a concentration ≧1% at 25° C. and neutral pH and having a melting temperature (gel to sol) of 35 to 60° C. when the glucan is dissolved in water at a concentration of 2%, methods for the production thereof, medical uses thereof, physical supports having the glucan applied thereto or impregnated thereon and in vitro methods of proliferation of skin cells which comprise contacting a population of skin cells with the glucan.

    摘要翻译: 本发明涉及基于单链的重均摩尔质量为15,000至50,000g / mol且水溶液中重均摩尔质量基于聚合物为4至20×10 5 g / mol且存在的葡聚糖 在25℃和中性pH下在水溶液中以≥1%的浓度呈凝胶形式,并且当葡聚糖以2%的浓度溶解于水中时具有35至60℃的熔融温度(凝胶至溶胶),方法 用于其生产,其医疗用途,具有施用于其上或浸渍于其上的葡聚糖的物理载体和体外皮肤细胞增殖方法,其包括使皮肤细胞群体与葡聚糖接触。