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    METABOLIC DETOXIFICATION SYSTEM AND METHOD
    3.
    发明公开
    METABOLIC DETOXIFICATION SYSTEM AND METHOD 审中-公开
    代谢脱毒系统和方法

    公开(公告)号：EP1747056A2

    公开(公告)日：2007-01-31

    申请号：EP05714053.5

    申请日：2005-02-23

    申请人： VITAL THERAPIES, INC.

    发明人： HE, Dar ,  BROTHERTON, John, D.

    IPC分类号： B01D61/20

    CPC分类号： A61M1/3472 ,  A61M1/1694 ,  A61M1/1698 ,  A61M1/3475 ,  A61M1/3489

    摘要： An extracorporeal filtration and detoxification system and method generally comprise separating ultrafiltrate from cellular components of blood, treating the ultrafiltrate independently of the cellular components in a recirculation circuit, recombining treated ultrafiltrate and the cellular components, and returning whole blood to the patient. A recirculation circuit generally comprises an active cartridge including active cells operative to effectuate a selected treatment; in some embodiments, the active cells are the C3A cell line.

    摘要翻译： 体外过滤和解毒系统和方法通常包括从血液的细胞组分分离超滤液，在再循环回路中独立于细胞组分处理超滤液，重新组合处理的超滤液和细胞组分，并将全血返回给患者。 再循环回路通常包括主动药筒，主动药筒包括可操作以实现选定治疗的活动细胞; 在一些实施方案中，活性细胞是C3A细胞系。

    ARTIFICIAL PANCREATIC PERFUSION DEVICE WITH RESEEDABLE MATRIX
    9.
    发明授权
    ARTIFICIAL PANCREATIC PERFUSION DEVICE WITH RESEEDABLE MATRIX 失效
    具有可复用基质的人工胰腺灌注装置

    公开(公告)号：EP0577719B1

    公开(公告)日：1996-06-05

    申请号：EP92909209.6

    申请日：1992-03-24

    申请人： W.R. Grace & Co.-Conn.

    发明人： CHICK, William, L. ,  RUPP, Randall, G.

    IPC分类号： A61F2/02

    CPC分类号： A61L27/04 ,  A61F2/022 ,  A61L27/14 ,  A61M1/1678 ,  A61M1/3472 ,  A61M1/3475

    摘要： A device which serves as an artificial pancreas comprises a hollow fiber (12) which is surrounded by islets of Langerhans (14) enclosed in a housing (22). The islets are suspended in a semi-gel matrix (25) or supporting material that is sufficiently viscous to physically support and maintain location of the islets about the hollow fiber, but sufficiently fluid to enable removal of the islet suspension from the device, followed by reseeding or replacement with fresh islet suspension. The matrix in which the islets are suspended preferably comprises calcium sodium alginate. The semi-gel supporting material also enables long term maintenance of islet cells in in vitro culture.

    摘要翻译： 一种用作人造胰腺的装置包括一个中空纤维（12），该中空纤维（12）被包围在壳体（22）中的朗格汉斯小岛（14）包围。 胰岛悬浮在半凝胶基质（25）或支撑材料中，所述材料足够粘稠以物理地支撑和维持胰岛围绕中空纤维的位置，但是具有足够的流动性以使得能够从装置中去除胰岛悬浮液，随后 重新种植或用新鲜的胰岛悬浮液替换。 其中悬浮胰岛的基质优选包含藻酸钙钠。 半凝胶支撑材料还能够在体外培养中长期维持胰岛细胞。

    A PLASMA FILTER SORBENT SYSTEM FOR REMOVAL OF COMPONENTS FROM BLOOD; IMPROVED MASS TRANSPORT SYSTEM
    10.
    发明公开
    A PLASMA FILTER SORBENT SYSTEM FOR REMOVAL OF COMPONENTS FROM BLOOD; IMPROVED MASS TRANSPORT SYSTEM 失效
    PHARMAFILTERSORBENTSYSTEM对废水血液的成分，改进的大交通体系。

    公开(公告)号：EP0643614A1

    公开(公告)日：1995-03-22

    申请号：EP92911351.0

    申请日：1992-04-30

    申请人： RESEARCH MEDICAL, INC.

    发明人： SHETTIGAR, Udipi ,  MCREA, James, C.

    IPC分类号： A61M1 ,  B01D61 ,  B01D63

    CPC分类号： B01D61/145 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3486 ,  B01D63/02 ,  B01D63/024 ,  B01D2313/40 ,  B01D2315/06 ,  Y10T436/255

    摘要： A system and method of achieving both convective and diffusive transport of plasma across a membrane (30) accompanied by the selective removal of plasma components using sorbents (33) followed by reinfusion of the purified plasma in a blood circulation system is achieved by pumping blood through a filter (30) comprising a bundle of ''U'' shaped hollow fibers immersed in a closed plasma chamber (31) containing sorbents (33) in a plasma chamber solution (32). As blood flows through the entry arm (32), due to positive transmembrane pressure difference, plasma filtration into the plasma chamber (31) occurs. However, the transmembrane pressure difference is negative when blood flows out of the exit arm (39) of filter (30) and the direction of filtration reverses causing reverse filtration/reinfusion of plasma from the chamber (31) into the blood in the exit arm (39).