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    A process for the recovery of a peptide-containing compound
    5.
    发明公开
    A process for the recovery of a peptide-containing compound 失效
    一种用于获得键的肽化合物的过程。

    公开(公告)号：EP0127737A1

    公开(公告)日：1984-12-12

    申请号：EP84103080.2

    申请日：1984-03-21

    申请人： Gambro Lundia AB

    发明人： Nylen, Ulf Thomas Gustav ,  Mattiasson, Bo Gustav

    IPC分类号： C07K1/14 ,  C07K3/28 ,  A61K37/02 ,  B01D13/00

    CPC分类号： C07K1/36 ,  B01D15/1871 ,  B01D15/3804 ,  B01D15/3809 ,  B01D61/147 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/32 ,  C07K1/34

    摘要： A process and an arrangement forthe recovery of a compound, for example a peptide-containing compound, from a solution through combined affinity-chromatographic purification and ultrafiltration. The process comprises the bringing into contact of the said compound in solution with a ligand bound to a carrier capable of reacting with the peptide-containing compound so as to form a complex and subsequently the splitting off and separating of the peptide-containing compound from the complex formed. As a carrier a macromolecular solid material is used, preferably in the form of particles larger than 0.1 µm which are selected among cells, agarose, starch, cellulose, chitin, gelatine, collagen and synthetic polymers of the latex and acrylic derivatives type, as well as inorganic material, for example ceramic material, porous siliceous material etc. The peptide-containing compound is separated by using a membrane filter (2) comprising a semipermeable membrane (13) with a cut-off between 50 000 and 100 x 10 . Dalton. The impurities are separated with the help of a membrane filter (2) comprising a semipermeable membrane (12) with a cut-off between 50 000 and 100 x 10 6 Dalton.