摘要:
A system (10) and method for increasing gas concentration in blood which has use a generalized extracorporeal system (10) and method to treat hypoxemic blood from a patient (24) by mixing the blood with an oxygen supersaturated solution to generate hyperoxemic blood to be infused back to the patient (24). The extracorporeal system (10) comprises an extracorporeal tubing (12) through which blood from the patient (24) is circulated, a blood pump (14) for withdrawing blood from and delivering blood to the patient (24), at least one channel (18) for delivering oxygen-supersaturated fluid and a mixing region (39) for introducing supersaturated fluid without bubble formation. By infusing the oxygen-supersaturated fluid into the hypoxemic or normoxemic blood from the patient (24), hyperoxemic blood is thereby produced. The hyperoxemic blood is then returned to a central vein, right heart or artery of the patient (24) with the blood pump (14) at approximately the same volume delivery rate as blood volume withdrawal rate.
摘要:
A combined heat exchanger/blood reservoir, comprises a housing (42) topped by a lid (44) together defining a reservoir chamber (52) within, a venous blood inlet (66) in the lid and a heat exchanger within the chamber including a plurality of heat exchange elements (88). The heat exchange chamber (86) is defined by guides (82, 84) closely surrounding the heat exchange elements (88) and extending downward from a location at an upper portion of the reservoir chamber, the heat exchange chamber (86) having an upper inlet (80) open to the venous blood inlet and a lower outlet (92) open to the reservoir chamber so that blood from the venous blood inlet must flow through the heat exchange chamber before reaching the reservoir chamber. A blood outlet (118) is provided in a lower portion of the reservoir chamber.
摘要:
The obstruction of a curved blood manifold window (27) in a blood oxygenator (10) by oxygenation fibers (46) which lie along a chord (58) of a curved window (27) when wound upon the oxygenator core (44) is avoided by recessing the manifold wall portions (38) most closely adjacent the window (27) sufficiently so that the fibers (46) lying on that chord (58) remain sufficiently spaced from those closest wall portions (38) to allow blood flow between those wall portions (38) and the closest fibers (46).
摘要:
A device (1) for oxygenating blood in an extracorporeal circuit includes a first structure (2) suitable to delimit a portion of space (6)-containing capillaries made of microporous membrane. The capillaries convey oxygen and are wet externally by blood flowing through a portion of space (6) between an intake connector (8), which is connected to a venous line of the extracorporeal circuit, and a delivery connector (10). The device (1) includes a second structure (3) monolithically connected and contiguous to the first structure (2). The second structure (3) is suitable to contain blood filtration means (28) that divide the portion of space delimited thereby into a blood distribution chamber (11), provided with an air vent (15) and connected to the delivery connector (10) of the first structure (2), and a blood collection chamber (13) provided with a delivery connector (10) connected to the arterial line of the extracorporeal circuit.
摘要:
A low prime membrane oxygenator (150) and an integrated heat exchanger/reservoir (24, 40) for use alone or in combination in an extracorporeal blood circuit. The oxygenator has a simple, five-part construction including a housing (152) defining an annular oxygenation chamber (168) within which a plurality of hollow fibers (160) are arranged in an annular bundle with flow spaces therebetween. A blood inlet port and manifold deliver blood through a plurality of evenly circumferentially spaced inlet apertures to the oxygenation chamber, and blood flows generally axially through the elongated annular chamber to a plurality of evenly circumferentially spaced outlet apertures. Specific geometric ratios, a particular hollow fiber architecture, and the absence of a heat exchange function, all combine to reduce the prime volume required by the oxygenator. The reservoir (24, 40) includes heat exchange coils (88) in an annular chamber (86) providing efficient heat transfer with low prime volume.
摘要:
The invention provides a coating for microporous hollow fibre membrane blood oxygenators which is capable of increasing the resistance of the fibres to passage of blood plasma through the micropores. The coating comprises an alkoxysilane/alkylsilane copolymer, preferably an aminoalkylsiloxane.
摘要:
A blood membrane oxygenator (10) having a housing (12) defining a blood flow path (13), a rotor hub in the form of a double lumen shaft (14), and a plurality of distributor disks (16) each having a plurality of hollow fibers (48) which extend across the housing blood flow path (13). The plurality of distributor disks (16) rotate within the housing (12) to mix the blood resulting in three-dimensional mixing, disruption of the blood boundary layer and efficient blood oxygenation.
摘要:
An elongated intravenous percutaneous oxygenator is described having a first and a second set of hollow gas permeable and liquid impermeable fibers, the fibers of each set having an input end and an output end, at least three longitudinally spaced manifolds in communication with one of said input ends or output ends of said fibers, gas delivery means in communication with the input ends of said fibers and gas exhaust means in communication with said output ends and inflatable balloon means disposed longitudinally of said oxygenator so as to be surrounded by said fibers, and gas inflation means in communication with said balloon means for inflating and deflating the balloon means.
摘要:
Pompe centrifuge intégrée à faible volume d'amorçage et oxygénateur à membrane comprenant un carter (10) contenant une couche de transfert de masse (40) constituée par des fibres de membrane creuses (38) perméables aux gaz situées sur la circonférence d'un anneau entourant un rotor (30). La couche de transfert de masse (40) est constituée par des enroulements multiples d'un ruban de fibres (42) comprenant au moins deux couches de fibres (38) adhérant selon un sens précis à des fibres de couches alternées s'alignant sur l'ouverture située entre les fibres des couches supérieures et inférieures. Des moyens d'adhérence permettent d'orienter les fibres (38) avec précision. Un faible volume du canal d'écoulement du rotor permet de diminuer davantage le volume d'amorçage.