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    Oxime carboxylic acid derivatives
    2.
    发明公开
    Oxime carboxylic acid derivatives 有权
    肟羧酸衍生物

    公开(公告)号：EP0980863A1

    公开(公告)日：2000-02-23

    申请号：EP99115880.9

    申请日：1999-08-12

    申请人： Givaudan Roure (International) S.A.

    发明人： Anderson, Denise ,  Frater, Georg

    IPC分类号： C07C251/62 ,  C07C271/62 ,  A61K7/40 ,  A61K7/48

    CPC分类号： A61K8/40 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q17/005 ,  C07C251/62 ,  C07C251/66 ,  C07C251/68 ,  C07C2602/42

    摘要： Oxime carboxylic acid derivatives having the formula I
    wherein n is either 1 or 0, X represents O or N, R 2 and R 3 represent any rests of an oxime R 2 R 3 NOH and R 1 represents a substituted or unsubstituted, branched or unbranched alkyl-, alkenyl-,akinyl-, cycloalkyl-, cycloalkenyl-, alkoxyalkyl-, aryloxyaryl-, alkoxyaryl-, aryloxyalkyl- or aromatic radical, preferably with 1 to 30 C atoms, or X n R 1 represents
    are useful as precursors for the delivery of organoleptic compounds, especially for flavors, fragrances and masking agents, and/or antimicrobial compounds.

    摘要翻译： 具有式I的肟羧酸衍生物，其中n是1或0，X代表O或N，R2和R3代表肟R2R3 NOH的任何残基，R1代表取代或未取代的，支链或无支链的烷基 - ，链烯基 - 烷基 - ，环烷基 - ，环烯基 - ，烷氧基烷基 - ，芳氧基芳基 - ，烷氧基芳基 - ，芳氧基烷基 - 或芳香族基团，优选具有1至30个C原子，或XnR 1代表可用作递送感官化合物，特别是用于香料， 香料和掩蔽剂，和/或抗微生物化合物。

    Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
    6.
    发明公开
    Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents 失效
    氨基甲酸甲酯和邻苯二甲酸乙二醇酯支气管扩张剂和Antientzündungsmittel。

    公开(公告)号：EP0470805A1

    公开(公告)日：1992-02-12

    申请号：EP91307197.3

    申请日：1991-08-06

    申请人： AMERICAN HOME PRODUCTS CORPORATION

    发明人： Lombardo, Louis John

    IPC分类号： C07C271/60 ,  C07C251/62 ,  C07C49/255 ,  A61K31/15

    CPC分类号： C07C251/62 ,  C07C271/60 ,  C07C2601/08 ,  C07C2602/42 ,  Y10S514/826

    摘要： The invention concerns compounds of the formula
    wherein
    R is C₃₋₇ alkyl, C₃₋₇ cycloalkyl,

    R¹ is hydrogen, lower alkyl or
    a is 1-3;
    b is 1-3;
    c is 0-2;
    X, Y and Z are each independently, a bond, O, S or NH, with the proviso that if one of X or Y is O, S or NH, the other must be a bond;
    R² is amino, loweralkylamino, arylamino, loweralkoxy or aryloxy;
    R³ and R 3′ are independently is hydrogen, halo, hydroxy, lower alkoxy, aryloxy, loweralkanoyloxy, amino, lower alkylamino, arylamino or loweralkanoylamino;
    R⁴ and R⁵ are each independently hydrogen or lower alkyl;
    m is 0-4;
    n is 1-4; and
    o is 1-4, and oxime and ketone intermediates thereto. The compounds of formula I selectively inhibit an isoenzyme of 3′:5′-cyclic AMP phosphodiesterase located in pulmonary smooth muscle tissue and inflammatory cells and are bronchodilatory or anti-inflammatory and so are useful in the treatment of acute and chronic bronchial asthma as associated pathologies.

    摘要翻译： 本发明涉及式CHEM的化合物，其中R是C 3-7烷基，C 3-7环烷基，CH 2 CH 2是氢，低级烷基或者CH 2是1-3; b为1-3; c为0-2; X，Y和Z各自独立地为键，O，S或NH，条件是如果X或Y中的一个为O，S或NH，则另一个必须为键; R 2是氨基，低级烷基氨基，芳基氨基，低级烷氧基或芳氧基; R 3和R 3分别独立地是氢，卤素，羟基，低级烷氧基，芳氧基，低级烷酰氧基，氨基，低级烷基氨基，芳基氨基或低级烷酰基氨基; R 4和R 5各自独立地为氢或低级烷基; m为0-4; n为1-4; 和o为1-4，肟和酮为中间体。 式I化合物选择性抑制位于肺平滑肌组织和炎性细胞中的3分钟：5分钟环AMP磷酸二酯酶的同工酶，并且是支气管扩张或抗炎的，因此可用于治疗急性和慢性支气管哮喘，如相关 病症。