公开(公告)号：EP2709653B1

公开(公告)日：2017-11-22

申请号：EP12773975.3

申请日：2012-04-19

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： CHIORINI, John, A. ,  PASQUALE, Giovanni, Di ,  MANNUCCI, Edoardo

IPC分类号： A61K38/22 ,  C12N15/861 ,  C07K14/575 ,  A61P3/10 ,  A61P3/04

CPC分类号： A61K35/76 ,  A61K35/761 ,  A61K38/1703 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/04 ,  C07K14/48 ,  C07K14/57563 ,  C07K14/605 ,  C07K2319/055 ,  C07K2319/50 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14143

摘要： The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.

公开(公告)号：EP1532239A4

公开(公告)日：2007-06-20

申请号：EP03788380

申请日：2003-08-12

申请人： BOEHRINGER INGELHEIM PHARMA

发明人： RAJOTTE DANIEL ,  KABCENELL ALISA

IPC分类号： C12N15/09 ,  C07K14/435 ,  C07K19/00 ,  C12N5/10 ,  C12N9/64 ,  C12Q1/02 ,  G01N33/50 ,  G01N33/53 ,  G01N33/567 ,  C12N9/14 ,  C07H21/04 ,  C07K17/00 ,  C12N9/48 ,  C12N9/50 ,  C12N9/76 ,  C12P21/06 ,  C12Q1/34 ,  C12Q1/37

CPC分类号： G01N33/5005 ,  C07K14/43595 ,  C07K2319/055 ,  C07K2319/60

摘要： This invention relates to methods and compositions for targeting proteins to secretory lysosomes. The invention further provides methods of use in drug screening assays, and methods of purifying secretory lysosomes.

公开(公告)号：EP3244907A4

公开(公告)日：2018-07-25

申请号：EP16737836

申请日：2016-01-13

申请人： HOPE CITY ,  THOMAS JEFFERSON UNIV AND HEALTH SYSTEM INNOVATION PILLAR

发明人： WILLIAMS JOHN ,  RODECK ULRICH

IPC分类号： C07K14/705 ,  C12N15/62

CPC分类号： C07K14/70521 ,  A61K38/00 ,  A61K47/64 ,  A61K47/65 ,  C07K2319/055 ,  C07K2319/50 ,  C07K2319/70 ,  C07K2319/74

摘要： Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer. The recombinant proteins provided herein are, inter alia, capable of binding CTLA-4 proteins on a tumor cell. In a first aspect, there is provided a recombinant CTLA-4 binding protein including (i) a CTLA-4 binding domain; (ii) a CTLA-4 binding domain masking peptide; and (iii) a cleavable peptide linker connecting the CTLA-4 binding domain masking peptide to the CTLA-4 binding domain. In another aspect, there is provided a dimerizing domain covalently attached to the CTLA-4 binding domain, wherein the binding protein domains are bound together.

公开(公告)号：EP2408926B1

公开(公告)日：2018-07-04

申请号：EP10754235.9

申请日：2010-03-22

申请人： Tetragenetics, Inc.

发明人： CLARK, Theodore, G. ,  PAPOYAN, Ashot ,  TURKEWITZ, Aaron

IPC分类号： C12P21/04 ,  A61K39/015 ,  C07K14/44 ,  C12N15/62 ,  A61K39/145 ,  A61K39/002 ,  C07K14/005 ,  C07K14/445 ,  A61K39/12 ,  A61K39/385

CPC分类号： C07K14/44 ,  A61K39/015 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K2039/6031 ,  C07K14/005 ,  C07K14/445 ,  C07K16/00 ,  C07K16/1278 ,  C07K2317/10 ,  C07K2317/622 ,  C07K2319/04 ,  C07K2319/055 ,  C07K2319/30 ,  C07K2319/50 ,  C12N2760/16122 ,  C12N2760/16134

摘要： This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production and purification of recombinant proteins in ciliates.

公开(公告)号：EP3004153A4

公开(公告)日：2016-12-21

申请号：EP14807031

申请日：2014-06-04

申请人： UNIV VIRGINIA COMMONWEALTH

发明人： FISHER PAUL B ,  BHOOPATHI PRAVEEN ,  DAS SWADESH K ,  EMDAD LUNI ,  SARKAR DEVANAND ,  SOKHI UPNEET

IPC分类号： C07K14/54 ,  A61K38/20 ,  C12N15/24 ,  C12N15/62

CPC分类号： C07K14/5428 ,  A61K38/00 ,  C07K14/54 ,  C07K2319/055

摘要： Recombinant therapeutic cytokines (“therakines”) for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 (“M4”) not normally found in nature that has anti-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.

摘要翻译： 提供了用于治疗癌症的重组治疗细胞因子（“治疗”）。 重组方法包括自然界中通常没有发现具有抗癌活性的MDA-7 / TL-24（“M4”）的截短区域，以及分泌信号，其导致质粒/病毒转导的正常和癌细胞的分泌 以及相邻的，相邻的和远处的癌细胞上的热休克蛋白与MDA-7 / IL-24受体的相互作用。 治疗相互作用导致旁观者杀死靶癌细胞以及相邻，相邻和远处的癌细胞。

公开(公告)号：EP2027281A4

公开(公告)日：2010-03-10

申请号：EP07756219

申请日：2007-05-04

申请人： GLYCOFI INC

发明人： HAMILTON STEPHEN R

IPC分类号： C12P21/06

CPC分类号： C12P21/005 ,  C07K2319/036 ,  C07K2319/05 ,  C07K2319/055 ,  C12N9/1081 ,  C12N9/2402 ,  C12Y302/01018

公开(公告)号：EP2763694B1

公开(公告)日：2018-01-03

申请号：EP12784427.2

申请日：2012-10-03

申请人： Statens Serum Institut

发明人： THEISEN, Michael ,  ANDERSEN, Gorm

IPC分类号： C07K14/47 ,  C12P21/02 ,  C12N15/62 ,  C12N15/74 ,  A61K39/015 ,  C07K14/445

CPC分类号： C07K14/445 ,  A61K39/015 ,  C07K14/4718 ,  C07K2319/055 ,  C12N15/62 ,  C12N15/746 ,  C12P21/02 ,  Y02A50/412

摘要： The present invention relates to a method for the production of correctly folded Pfs48/45. This is achieved in the lactococcus lactis when Pfs48/45 or fractions thereof are fused genetically to a glutamate rich protein, e.g. GLURP from Plasmodium falciparum.

公开(公告)号：EP2649178B8

公开(公告)日：2017-08-30

申请号：EP11791602.3

申请日：2011-12-09

申请人： Institut Pasteur

发明人： DESPRES, Philippe ,  PAULOUS, Sylvie ,  CRUBLET, Elodie

IPC分类号： C12N9/10 ,  C12N15/62

CPC分类号： C12N15/625 ,  C07K2319/00 ,  C07K2319/055 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/50 ,  C12N5/0601 ,  C12N5/0693 ,  C12N9/1007 ,  C12N9/96 ,  C12N15/85 ,  C12N2015/8518 ,  C12N2510/02 ,  C12P21/02 ,  C12Y201/01063 ,  Y02A50/51 ,  Y02A50/53 ,  Y02A50/60

摘要： The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.

公开(公告)号：EP2046370B1

公开(公告)日：2016-08-10

申请号：EP07733065.2

申请日：2007-06-01

申请人： Ipsen Bioinnovation Limited ,  ALLERGAN, INC.

发明人： FOSTER, Keith ,  CHADDOCK, John ,  MARKS, Philip ,  STANCOMBE, Patrick ,  AOKI, K., Roger ,  FRANCIS, Joseph ,  STEWARD, Lance

IPC分类号： A61K38/17

CPC分类号： C12Y304/24069 ,  A61K38/00 ,  A61K38/1709 ,  A61K38/482 ,  A61K38/4886 ,  A61K38/4893 ,  A61K47/6415 ,  A61K47/65 ,  C07K14/665 ,  C07K2319/055 ,  C07K2319/06 ,  C07K2319/50 ,  C12N9/52 ,  C12N15/62

公开(公告)号：EP2709653A4

公开(公告)日：2014-11-26

申请号：EP12773975

申请日：2012-04-19

申请人： US HEALTH

发明人： CHIORINI JOHN A ,  PASQUALE GIOVANNI DI ,  MANNUCCI EDOARDO

IPC分类号： A61K38/22 ,  A61P3/04 ,  A61P3/10 ,  C07K14/575 ,  C12N15/861

CPC分类号： A61K35/76 ,  A61K35/761 ,  A61K38/1703 ,  A61K48/005 ,  A61K48/0075 ,  C07H21/04 ,  C07K14/48 ,  C07K14/57563 ,  C07K14/605 ,  C07K2319/055 ,  C07K2319/50 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14143

摘要： The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.