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公开(公告)号：EP3230461A1
公开(公告)日：2017-10-18
申请号：EP15807648.9
申请日：2015-12-07
发明人： CHARNEAU, Pierre , DESPRES, Philippe , DE WISPELAERE, Melissanne , SOUQUE, Philippe , FRENKIEL, Marie-Pascale
CPC分类号： A61K39/12 , A61K9/19 , A61K47/26 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/552 , A61K2039/575 , C07K14/005 , C07K14/1825 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2740/15043 , C12N2740/16043 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/24171 , Y02A50/39
摘要： The present invention relates to a lentiviral vector-based Japanese encephalitis (JE) immunogenic composition. The present invention is directed to a recombinant lentiviral vector expressing the precursor of membrane (prM) and the envelope (E) protein, in particular glycoprotein of a Japanese encephalitis virus (JEV) or immunogenic fragments thereof. The present invention also provides cells expressing the lentiviral vector, uses and methods to prevent a JEV infection in a mammalian host, especially in a human or an animal host.
摘要翻译： 基于慢病毒载体的日本脑炎（JE）免疫原性组合物本发明涉及基于慢病毒载体的日本脑炎（JE）免疫原性组合物。 本发明涉及表达膜（prM）前体和包膜（E）蛋白，特别是日本脑炎病毒（JEV）的糖蛋白或其免疫原性片段的重组慢病毒载体。 本发明还提供了表达慢病毒载体的细胞，用于和预防哺乳动物宿主，尤其是人或动物宿主，特别是猪或小猪，优选家猪或家养仔猪JEV感染的方法。
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公开(公告)号：EP2649178B8
公开(公告)日：2017-08-30
申请号：EP11791602.3
申请日：2011-12-09
申请人： Institut Pasteur
CPC分类号： C12N15/625 , C07K2319/00 , C07K2319/055 , C07K2319/20 , C07K2319/21 , C07K2319/50 , C12N5/0601 , C12N5/0693 , C12N9/1007 , C12N9/96 , C12N15/85 , C12N2015/8518 , C12N2510/02 , C12P21/02 , C12Y201/01063 , Y02A50/51 , Y02A50/53 , Y02A50/60
摘要： The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
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公开(公告)号：EP1190257A1
公开(公告)日：2002-03-27
申请号：EP00951579.2
申请日：2000-06-09
申请人： INSTITUT PASTEUR
发明人： FLAMAND, Marie , MEGRET, Françoise , ALCON, Sophie , TALARMIN, Antoine , DESPRES, Philippe , DEUBEL, Vincent
IPC分类号： G01N33/569 , C07K14/18 , A61K39/12 , A61K48/00 , A61K39/395
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/505 , C07K16/1081 , C12N2770/24122 , C12N2770/24134 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/386 , Y02A50/53 , Y10S435/975
摘要： The invention concerns a method for early detection of a flavivirus-induced infection, comprising the detection of the flavivirus non-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
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4.发明授权MGMT-BASED METHOD FOR OBTAINING HIGH YIELD OF RECOMBINANT PROTEIN EXPRESSION 有权MGMT-BASIERTE方法ZUR ERZIELUNG HOHER AUSBEUTE BEI REKOMBINANTER蛋白表达
公开(公告)号：EP2649178B1
公开(公告)日：2017-03-15
申请号：EP11791602.3
申请日：2011-12-09
申请人： Institut Pasteur
CPC分类号： C12N15/625 , C07K2319/00 , C07K2319/055 , C07K2319/20 , C07K2319/21 , C07K2319/50 , C12N5/0601 , C12N5/0693 , C12N9/1007 , C12N9/96 , C12N15/85 , C12N2015/8518 , C12N2510/02 , C12P21/02 , C12Y201/01063 , Y02A50/51 , Y02A50/53 , Y02A50/60
摘要： The present invention relates to a novel enhancer of protein production in host cells. It discloses a vector for expressing recombinant proteins in these cells, comprising a nucleotide sequence encoding a) a secretion peptidic signal, b) a 6-methylguanine-DNA-methyltransferase enzyme (MGMT, EC 2.1.1.63), a mutant or a catalytic domain thereof, and c) a recombinant protein. Said MGMT enzyme is preferably the so-called SNAP protein.
摘要翻译： 本发明涉及一种在宿主细胞中产生蛋白质的新型增强子。 它公开了用于在这些细胞中表达重组蛋白质的载体，其包含编码a）分泌肽信号的核苷酸序列，b）6-甲基鸟嘌呤-DNA-甲基转移酶（MGMT，EC2.1.1.63），突变体或催化结构域 和c）重组蛋白。 所述MGMT酶优选为所谓的SNAP蛋白。
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公开(公告)号：EP2197912A2
公开(公告)日：2010-06-23
申请号：EP08828940.0
申请日：2008-09-04
申请人： Institut Pasteur
IPC分类号： C07K16/10 , G01N33/569
CPC分类号： C07K16/1081 , G01N33/56983 , G01N2333/18 , G01N2469/10 , Y02A50/51
摘要： The present invention relates to the field of arbovirosis caused by Chikungunya virus (CHIK). The present invention specifically concerns anti-CHIK monoclonal antibodies (MAbs), and more specifically anti-CHIK.E2 MAbs and their use as diagnostic products in methods for detecting the presence or absence of a CHIK strain.
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6.发明授权DC-SIGN BLOCKERS AND THEIR USE FOR PREVENTING OR TREATING VIRAL INFECTIONS. 有权DC-SIGN受体阻滞剂和它们用于病毒感染的预防和治疗
公开(公告)号：EP1562628B1
公开(公告)日：2009-04-15
申请号：EP03810566.4
申请日：2003-11-05
CPC分类号： G01N33/566 , A61K38/162 , A61K2039/505 , C07K16/2851 , C07K16/2896 , G01N33/6872 , G01N2333/70596 , G01N2500/00 , G01N2500/10 , Y02A50/386 , Y02A50/53
摘要： The present invention relates to methods and compositions for preventing or treating diseases of a mammal, including viral infections, wherein at least one symptom of the disease is mediated at least in part by the binding of an effector molecule to a DC-SIGN receptor present on cells of the mammal to be treated. The invention also provides methods of identifying compositions, wherein the compositions are useful for treating mammalian diseases, including viral infections, for which at least one symptom of the disease is mediated at least in part by the specific binding of an effector molecule to a DC-SIGN receptor present on the cells that express the DC-SIGN receptor, belonging to the mammal to be treated. The invention further relates to compositions and methods for targeting subject molecules to cells that express the DC-SIGN receptor.
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公开(公告)号：EP1383796B1
公开(公告)日：2009-04-15
申请号：EP02759815.0
申请日：2002-04-04
发明人： DESPRES, Philippe , DEUBEL, Vincent , GUENET, Jean-Louis , DROUET, Marie-Thérèse, Institut Pasteur , MALKINSON, Mertyn, Kimron Veterinary Institute , BANET, Caroline, Kimron Veterinary Institute , FRENKIEL, Marie-Pascale , COURAGEOT, Marie-Pierre , COULIBALY, Fasséli , CATTEAU, Adeline , FLAMAND, Marie , WEBER, Patrick , CECCALDI, Pierre-Emmanuel
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , Y02A50/394
摘要： The invention relates to a neuroinvasive and neurovirulent strain of the West Nile virus, known as IS-98-ST1, nucleic acid molecules originating from the genome thereof, proteins and peptides coded by said nucleic acid molecules. The invention also relates to the applications of same.
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8.发明公开RECOMBINANT LENTIVIRAL VECTOR FOR EXPRESSION OF A FLAVIVIRIDAE PROTEIN AND APPLICATIONS THEREOF AS A VACCINE 有权为了表达黄病毒科病毒的蛋白质重组慢病毒载体，其使用作为疫苗
公开(公告)号：EP1751291A1
公开(公告)日：2007-02-14
申请号：EP05748053.5
申请日：2005-05-16
IPC分类号： C12N15/867 , C07K14/18
CPC分类号： C12N15/86 , A61K2039/53 , C07K14/005 , C12N2740/16043 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/394
摘要： Use of a recombinant lentiviral vector comprising a polynucleotide fragment encoding at least one protein of a virus of the family Flaviviridae or an immunogenic peptide of at least 8 amino acids of said protein, for preparing a pharmaceutical composition intended for the prevention and/or the treatment of a Flaviviridae infection in a sensitive species.
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9.发明公开DC-SIGN BLOCKERS AND THEIR USE FOR PREVENTING OR TREATING VIRAL INFECTIONS. 有权DC-SIGN受体阻滞剂和它们用于病毒感染的预防和治疗
公开(公告)号：EP1562628A1
公开(公告)日：2005-08-17
申请号：EP03810566.4
申请日：2003-11-05
CPC分类号： G01N33/566 , A61K38/162 , A61K2039/505 , C07K16/2851 , C07K16/2896 , G01N33/6872 , G01N2333/70596 , G01N2500/00 , G01N2500/10 , Y02A50/386 , Y02A50/53
摘要： The present invention relates to methods and compositions for preventing or treating diseases of a mammal, including viral infections, wherein at least one symptom of the disease is mediated at least in part by the binding of an effector molecule to a DC-SIGN receptor present on cells of the mammal to be treated. The invention also provides methods of identifying compositions, wherein the compositions are useful for treating mammalian diseases, including viral infections, for which at least one symptom of the disease is mediated at least in part by the specific binding of an effector molecule to a DC-SIGN receptor present on the cells that express the DC-SIGN receptor, belonging to the mammal to be treated. The invention further relates to compositions and methods for targeting subject molecules to cells that express the DC-SIGN receptor.
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10.发明授权POLYPEPTIDES CHIMERIQUES ET LEURS APPLICATIONS THÉRAPEUTIQUES CONTRE UNE INFECTION À FLAVIVIRIDAE 有权CHIMÄRISCHEPOLYPEPTIDE UND IHRE THERAPEUTISCHE VERWENDUNG GEGEN FLAVIVIRIDAE-INFEKTIONEN
公开(公告)号：EP1893228B1
公开(公告)日：2016-03-23
申请号：EP06778626.9
申请日：2006-06-20
发明人： TANGY, Frédéric , LUCAS-HOURANI, Marianne , NAVARRO-SANCHEZ, Erika , FRENKIEL, Marie-Pascale , BEDOUELLE, Hugues , COMBREDET, Chantal , DESPRES, Philippe
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/165 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , C07K2319/00 , C07K2319/04 , C12N7/00 , C12N15/86 , C12N2760/18434 , C12N2760/18443 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
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