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公开(公告)号：EP1005377A2
公开(公告)日：2000-06-07
申请号：EP98943466.7
申请日：1998-08-28
发明人： LAROCCA, David , BAIRD, Andrew , JOHNSON, Wendy
CPC分类号： C40B40/02 , A61K47/6901 , A61K48/00 , C07K14/005 , C07K14/503 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N15/86 , C12N15/87 , C12N2795/10022 , C12N2795/10043 , C12N2795/10045 , C12N2795/14122 , C12N2810/851
摘要： Filamentous phage particles displaying a ligand on their surface are used to deliver a therapeutic gene to a cell. The ligand is a fusion protein with a phage capsid protein, covalently conjugated to phage particles, or complexed with modified phage particles.
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公开(公告)号：EP2997148A1
公开(公告)日：2016-03-23
申请号：EP14723873.7
申请日：2014-05-12
发明人： HAJITOU, Amin , YATA, Teerapong
CPC分类号： A61K35/76 , C07K2319/00 , C07K2319/09 , C07K2319/74 , C12N15/86 , C12N2795/10043 , C12N2795/10045
摘要： The invention provides a recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage. The bacteriophage comprises a first nucleic acid sequence encoding a pill capsid minor coat protein that is configured to display a cell-targeting ligand for enabling delivery of the bacteriophage to a target cell, a second nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a foreign peptide thereon, and a transgene which encodes a protein which exerts a biological effect on the target cell.
摘要翻译： 本发明提供用于在用噬菌体转导的靶细胞中表达转基因的重组靶向噬菌体。 噬菌体包含编码药盒衣壳小外壳蛋白的第一核酸序列，其配置为显示用于使噬菌体递送至靶细胞的细胞靶向配体，编码至少一种pVIII衣壳主要外壳蛋白的第二核酸序列 被配置为在其上显示外来肽，以及编码在靶细胞上发挥生物学作用的蛋白质的转基因。
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公开(公告)号：EP1812585A4
公开(公告)日：2008-06-11
申请号：EP05824860
申请日：2005-10-31
发明人： STAVE JAMES W , TEANEY GEORGE B
CPC分类号： C12Q1/04 , C12N7/00 , C12N2795/00011 , C12N2795/10045 , C12Q1/10 , G01N2333/005 , G01N2333/255
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公开(公告)号：EP1812585A2
公开(公告)日：2007-08-01
申请号：EP05824860.0
申请日：2005-10-31
IPC分类号： C12Q1/10
CPC分类号： C12Q1/04 , C12N7/00 , C12N2795/00011 , C12N2795/10045 , C12Q1/10 , G01N2333/005 , G01N2333/255
摘要： Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages to control the growth of non-target populations provides superior sensitivity and specificity to detection assays and reduces false negative and false positive results. The removal of contaminating bacteria reduces the microbial competition for nutrients in the growth media thereby increasing the efficiency and productivity of the culture. The phage treatment of the sample increases the proportion of target microorganisms in the sample over contaminating bacteria thereby requiring less time for enrichment to obtain a significant signal improving overall signal to noise ratio in assays and providing for higher yield of end product in microbiological production systems.
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公开(公告)号：EP2997148B1
公开(公告)日：2018-11-21
申请号：EP14723873.7
申请日：2014-05-12
发明人： HAJITOU, Amin , YATA, Teerapong
CPC分类号： A61K35/76 , C07K2319/00 , C07K2319/09 , C07K2319/74 , C12N15/86 , C12N2795/10043 , C12N2795/10045
摘要： The invention provides a recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage. The bacteriophage comprises a first nucleic acid sequence encoding a pill capsid minor coat protein that is configured to display a cell-targeting ligand for enabling delivery of the bacteriophage to a target cell, a second nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a foreign peptide thereon, and a transgene which encodes a protein which exerts a biological effect on the target cell.
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公开(公告)号：EP2997149A1
公开(公告)日：2016-03-23
申请号：EP14723874.5
申请日：2014-05-12
发明人： HAJITOU, Amin , YATA, Teerapong
CPC分类号： A61K39/385 , A61K35/76 , A61K47/543 , A61K47/59 , A61K47/61 , A61K47/645 , A61K47/6901 , A61K47/6921 , A61K48/00 , A61K2039/5256 , A61K2039/55583 , C07K2319/74 , C12N15/86 , C12N2795/10043 , C12N2795/10045
摘要： The invention provides a targeted bacteriophage-polymer complex comprising a recombinant targeted-bacteriophage and a cationic polymer. The complex has a net positive charge. The invention provides methods of preparing bacteriophages and complexes thereof, and to their uses for the delivery of transgenes in a variety of gene therapy applications.
摘要翻译： 本发明提供了包含重组靶向噬菌体和阳离子聚合物的靶向噬菌体 - 聚合物复合物。 该综合体有净正电荷。 本发明提供了制备噬菌体及其复合物的方法，以及它们在各种基因治疗应用中递送转基因的用途。
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公开(公告)号：EP1812585B1
公开(公告)日：2014-08-06
申请号：EP05824860.0
申请日：2005-10-31
CPC分类号： C12Q1/04 , C12N7/00 , C12N2795/00011 , C12N2795/10045 , C12Q1/10 , G01N2333/005 , G01N2333/255
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