公开(公告)号：EP2801612A4

公开(公告)日：2015-07-29

申请号：EP13733832

申请日：2013-01-03

申请人： CJ CHEILJEDANG CORP

发明人： SHIN YONG UK ,  KIM SO YOUNG ,  HEO IN KYUNG ,  KIM JU EUN ,  SON SUNG KWANG ,  LEE JAE HEE ,  LEE JI HYUN ,  KIM CHANG GYEOM

IPC分类号： C12N1/21 ,  C12N15/62 ,  C12P17/10

CPC分类号： C12P17/12 ,  C12N9/0022 ,  C12N9/1085 ,  C12N15/52 ,  C12N15/62 ,  C12N15/70 ,  C12Y104/03016 ,  C12Y205/01072 ,  Y02P20/52

摘要： The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.

摘要翻译： 本发明涉及表达通过接头连接的L-天冬氨酸氧化酶和喹啉酸合成酶的融合蛋白质的喹啉酸生产重组微生物，以及使用其生产喹啉酸的方法。

公开(公告)号：EP3168293A4

公开(公告)日：2017-11-29

申请号：EP15818940

申请日：2015-06-30

申请人： CJ CHEILJEDANG CORP

发明人： CHANG JIN SOOK ,  KIM JU EUN ,  KIM SO YOUNG ,  NA KWANG HO ,  SHIN YONG UK ,  LEE JAE MIN ,  LEE JAE HEE ,  HEO IN KYUNG

IPC分类号： C12N1/21 ,  C12N15/09 ,  C12P17/10

CPC分类号： C12N15/70 ,  C12N9/0022 ,  C12N9/1077 ,  C12N9/1085 ,  C12N15/09 ,  C12N15/52 ,  C12P17/10 ,  C12P17/12 ,  C12Y104/03016 ,  C12Y204/02019 ,  C12Y205/01072

摘要： The present invention relates to a recombinant microorganism producing quinolinic acid, more particularly, a microorganism producing quinolinic acid and having attenuated activity or eliminated activity of a protein having a sequence of SEQ ID NO: 1 and a method of producing quinolinic acid by using the recombinant microorganism.

公开(公告)号：EP2829602B1

公开(公告)日：2018-01-31

申请号：EP14178598.0

申请日：2014-07-25

申请人： CJ Cheiljedang Corporation

发明人： Kim, So Young ,  Shin, Yong Uk ,  Heo, In Kyung ,  Kim, Ju Eun ,  Na, Kwang Ho ,  Seo, Chang Il ,  Son, Sung Kwang ,  Lee, Jae Hee

IPC分类号： C12N9/06 ,  C12P17/12

CPC分类号： C12N9/0022 ,  C12P17/12 ,  C12Y104/03016

摘要： To produce quinolinate effectively, a L-aspartate oxidase variant that the feedback regulation by nicotinic acid or NAD is released, and a microorganism including the L-aspartate oxidase variant are provided. Quinolinate may be effectively produced by culturing of the microorganism including the L-aspartate oxidase variant.

公开(公告)号：EP2801612B1

公开(公告)日：2017-11-22

申请号：EP13733832.3

申请日：2013-01-03

申请人： Cj Cheiljedang Corporation

发明人： SHIN, Yong Uk ,  KIM, So Young ,  HEO, In Kyung ,  KIM, Ju Eun ,  SON, Sung Kwang ,  LEE, Jae Hee ,  LEE, Ji Hyun ,  KIM, Chang Gyeom

IPC分类号： C12N1/21 ,  C12N15/62 ,  C12P17/10

CPC分类号： C12P17/12 ,  C12N9/0022 ,  C12N9/1085 ,  C12N15/52 ,  C12N15/62 ,  C12N15/70 ,  C12Y104/03016 ,  C12Y205/01072 ,  Y02P20/52

摘要： The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.

公开(公告)号：EP3255150A1

公开(公告)日：2017-12-13

申请号：EP15881324.6

申请日：2015-12-28

申请人： CJ Cheiljedang Corporation

发明人： LEE, Jaemin ,  KIM, Ju Eun ,  LEE, Jae Hee ,  CHANG, Jin Sook ,  KIM, So Young ,  SHIN, Yong Uk

IPC分类号： C12N15/70 ,  C12N9/10 ,  C12P7/46

CPC分类号： C12N9/1085 ,  C12N9/0022 ,  C12N9/10 ,  C12N15/70 ,  C12P7/46 ,  C12P17/12 ,  C12Y104/03016 ,  C12Y205/01072

摘要： The present disclosure relates to a microorganism having producing ability of quinolinic acid and a method for producing quinolinic acid using the microorganism.

摘要翻译： 本发明涉及具有喹啉酸生产能力的微生物以及使用该微生物生产喹啉酸的方法。

公开(公告)号：EP2829602A1

公开(公告)日：2015-01-28

申请号：EP14178598.0

申请日：2014-07-25

申请人： CJ Cheiljedang Corporation

发明人： Kim, So Young ,  Shin, Yong Uk ,  Heo, In Kyung ,  Kim, Ju Eun ,  Na, Kwang Ho ,  Seo, Chang Il ,  Son, Sung Kwang ,  Lee, Jae Hee

IPC分类号： C12N9/06 ,  C12P17/12

CPC分类号： C12N9/0022 ,  C12P17/12 ,  C12Y104/03016

摘要： To produce quinolinate effectively, a L-aspartate oxidase variant that the feedback regulation by nicotinic acid or NAD is released, and a microorganism including the L-aspartate oxidase variant are provided. Quinolinate may be effectively produced by culturing of the microorganism including the L-aspartate oxidase variant.

摘要翻译： 为了有效地制备喹喔啉，提供了释放烟酸或NAD的反馈调节的L-天冬氨酸氧化酶变体，以及包含L-天冬氨酸氧化酶变体的微生物。 喹诺酮可以通过培养包含L-天冬氨酸氧化酶变体的微生物来有效地产生。

公开(公告)号：EP3168293A1

公开(公告)日：2017-05-17

申请号：EP15818940.7

申请日：2015-06-30

申请人： CJ Cheiljedang Corporation

发明人： CHANG, Jin Sook ,  KIM, Ju Eun ,  KIM, So Young ,  NA, Kwang Ho ,  SHIN, Yong Uk ,  LEE, Jae Min ,  LEE, Jae Hee ,  HEO, In Kyung

IPC分类号： C12N1/21 ,  C12N15/09 ,  C12P17/10

CPC分类号： C12N15/70 ,  C12N9/0022 ,  C12N9/1077 ,  C12N9/1085 ,  C12N15/09 ,  C12N15/52 ,  C12P17/10 ,  C12P17/12 ,  C12Y104/03016 ,  C12Y204/02019 ,  C12Y205/01072

摘要： The present invention relates to a recombinant microorganism producing quinolinic acid, more particularly, a microorganism producing quinolinic acid and having attenuated activity or eliminated activity of a protein having a sequence of SEQ ID NO: 1 and a method of producing quinolinic acid by using the recombinant microorganism.

摘要翻译： 本发明涉及的重组微生物生产喹啉酸，更具体地说，微生物生产喹啉酸和具有减毒活性或具有SEQ ID NO的序列的蛋白质的除去的活性：1，通过使用重组生产喹啉酸的方法 微生物。

公开(公告)号：EP2801612A2

公开(公告)日：2014-11-12

申请号：EP13733832.3

申请日：2013-01-03

申请人： Cj Cheiljedang Corporation

发明人： SHIN, Yong Uk ,  KIM, So Young ,  HEO, In Kyung ,  KIM, Ju Eun ,  SON, Sung Kwang ,  LEE, Jae Hee ,  LEE, Ji Hyun ,  KIM, Chang Gyeom

IPC分类号： C12N1/21 ,  C12N15/62 ,  C12P17/10

CPC分类号： C12P17/12 ,  C12N9/0022 ,  C12N9/1085 ,  C12N15/52 ,  C12N15/62 ,  C12N15/70 ,  C12Y104/03016 ,  C12Y205/01072 ,  Y02P20/52

摘要： The present invention relates to a quinolinic acid-producing recombinant microorganism expressing a fusion protein of L-aspartate oxidase and quinolinate synthase linked via a linker, and a method for producing quinolinic acid using the same.