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1.发明公开
公开(公告)号：EP3783096A1
公开(公告)日：2021-02-24
申请号：EP20192891.8
申请日：2015-06-22
发明人： KIM, Hyun Ah , SEO, Ju Hee , SHIN, Yong Uk , KIM, So Young , KIM, Sang Kyoum , NA, Kwang Ho , BAE, Jee Yeon , SON, Sung Kwang , YOO, Hye Ryun , CHOI, Jin Geun
摘要： Disclosed is a microorganism of Escherichia sp. producing O -acetyl homoserine, and a method of producing O -acetyl homoserine in high yield using the microorganism.
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公开(公告)号：EP2663646B1
公开(公告)日：2018-09-12
申请号：EP12734376.2
申请日：2012-01-16
发明人： KIM, So Young , SHIN, Yong Uk , HEO, In Kyung , KIM, Ju Eun , SON, Sung Kwang , SEO, Chang Il , KIM, Hyun Ah , LEE, Han Jin , NA, Kwang Ho , BAE, Jee Yeon
IPC分类号： C12P17/12 , C07D213/80
CPC分类号： C12P17/12 , C07D213/80
摘要： A method for the preparation of nicotinic acid, which includes the step of obtaining a culture solution containing quinolinic acid by incubating a microorganism having an ability to produce quinolinic acid, and the step of adding an acid to the culture solution and conducting a decarboxylation reaction.
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3.发明公开RECOMBINANT MICROORGANISM PRODUCING QUINOLINIC ACID AND METHOD FOR PRODUCING QUINOLINIC ACID USING SAME 审中-公开Chinolinsäure生产重组微生物和方法是这样就产生Chinolinsäure
公开(公告)号：EP3168293A1
公开(公告)日：2017-05-17
申请号：EP15818940.7
申请日：2015-06-30
发明人： CHANG, Jin Sook , KIM, Ju Eun , KIM, So Young , NA, Kwang Ho , SHIN, Yong Uk , LEE, Jae Min , LEE, Jae Hee , HEO, In Kyung
CPC分类号： C12N15/70 , C12N9/0022 , C12N9/1077 , C12N9/1085 , C12N15/09 , C12N15/52 , C12P17/10 , C12P17/12 , C12Y104/03016 , C12Y204/02019 , C12Y205/01072
摘要： The present invention relates to a recombinant microorganism producing quinolinic acid, more particularly, a microorganism producing quinolinic acid and having attenuated activity or eliminated activity of a protein having a sequence of SEQ ID NO: 1 and a method of producing quinolinic acid by using the recombinant microorganism.
摘要翻译： 本发明涉及的重组微生物生产喹啉酸，更具体地说，微生物生产喹啉酸和具有减毒活性或具有SEQ ID NO的序列的蛋白质的除去的活性：1，通过使用重组生产喹啉酸的方法 微生物。
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4.发明公开MICROORGANISM PRODUCING O-ACETYL-HOMOSERINE AND THE METHOD OF PRODUCING O-ACETYL-HOMOSERINE USING THE MICROORGANISM 审中-公开微生物，O-乙酰高丝氨酸制定和方法产生O-乙酰高丝氨酸微生物法
公开(公告)号：EP3042950A1
公开(公告)日：2016-07-13
申请号：EP16156542.9
申请日：2010-03-11
发明人： KIM, So Young , SHIN, Yonk Uk , HEO, In Kyung , KIM, Hyun Ah , SEO, Chang Il , KIM, Ju Eun , SON, Sung Kwang , LEE, Sang Mok , JHON, Sung Hoo , LEE, Han Jin , NA, Kwang Ho
CPC分类号： C12N9/1217 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12P13/06
摘要： Disclosed is a strain of Escherichia sp., capable of producing 0-acetyl homoserine in high yield, with the introduction and enhancement therein of the activity of: homoserine acetyl transferase, aspartokinase and homoserine dehydrogenase; and at least one enzyme selected from a group consisting of phosphoenolpyruvate carboxylase, aspartate aminotransferase and aspartate semi-aldehyde dehydrogenase. Also, a method of producing 0-acetyl homoserine using the strain is provided.
摘要翻译： 。本发明公开了埃希氏菌属的菌株，能够以高产量产生O-乙酰高丝氨酸的，具有在其中的活性的引入和增强：高丝氨酸乙酰转移酶，天冬氨酸激酶和高丝氨酸脱氢酶; 和至少一种酶由选自由磷酸烯醇丙酮酸羧，天冬氨酸氨基转移酶和天冬氨酸半醛脱氢酶组成的组。 所以，提供了一种生产使用菌株0乙酰高丝氨酸的方法。
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5.发明公开NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME 有权新的O-乙酰丝氨酸硫化氢或版本体和方法使其转化蛋氨酸SO
公开(公告)号：EP2657249A2
公开(公告)日：2013-10-30
申请号：EP11850058.6
申请日：2011-12-21
发明人： KIM, So Young , SHIN, Yong Uk , SEO, Chang Il , SON, Sung Kwang , HEO, In Kyung , LEE, Han Jin , KIM, Ju Eun , KIM, Hyun Ah , BAE, Jee Yeon , NA, Kwang Ho
IPC分类号： C07K14/195 , C12N15/31 , C12N15/60 , C12N15/70
CPC分类号： C12N9/1085 , C12P7/54 , C12P13/12 , C12Y205/01049
摘要： The present invention relates to a novel protein having O-acetylhomoserine sulfhydrylase activity, a mutant protein thereof, a polynucleotide encoding the same, a recombinant vector comprising the polynucleotide, a microorganism transformed with the recombinant vector, and a method for producing methionine or acetic acid using the protein. The production method of the present invention has the advantage of producing L-methionine and acetic acid cost-effectively through having higher conversion rate and reduced reaction time compared to the existing methods, and it can minimize the amount of enzyme homogenate added when using the mutant protein, thereby easily producing L-methionine and acetic acid at high yield.
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公开(公告)号：EP3168293B1
公开(公告)日：2020-01-15
申请号：EP15818940.7
申请日：2015-06-30
发明人： CHANG, Jin Sook , KIM, Ju Eun , KIM, So Young , NA, Kwang Ho , SHIN, Yong Uk , LEE, Jae Min , LEE, Jae Hee , HEO, In Kyung
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7.发明授权NOVEL O-ACETYLHOMOSERINE SULFHYDRYLASE OR VARIANT THEREOF, AND METHOD FOR TRANSFORMING METHIONINE USING SAME 有权新的O-乙酰丝氨酸硫化氢或版本体和方法使其转化蛋氨酸SO
公开(公告)号：EP2657249B1
公开(公告)日：2017-03-15
申请号：EP11850058.6
申请日：2011-12-21
发明人： KIM, So Young , SHIN, Yong Uk , SEO, Chang Il , SON, Sung Kwang , HEO, In Kyung , LEE, Han Jin , KIM, Ju Eun , KIM, Hyun Ah , BAE, Jee Yeon , NA, Kwang Ho
CPC分类号： C12N9/1085 , C12P7/54 , C12P13/12 , C12Y205/01049
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8.发明公开MICROORGANISM PRODUCING O-SUCCINYL HOMOSERINE AND METHOD FOR PRODUCING O-SUCCINYL HOMOSERINE BY USING SAME 审中-公开产生O-琥珀酰高丝氨酸的微生物以及使用相同方法生产O-琥珀酰高丝氨酸的方法
公开(公告)号：EP3061814A1
公开(公告)日：2016-08-31
申请号：EP14855796.0
申请日：2014-10-22
发明人： SEO, Chang Il , KIM, So Young , SHIN, Yong Uk , NA, Kwang Ho , UM, Hye Won , HEO, In Kyung
CPC分类号： C12P13/06 , C12N9/1029 , C12Y203/01046
摘要： The present invention relates to a polypeptide which is resistant to feedback inhibition by methionine and has an activity of homoserine O -succinyltransferase, a microorganism for producing O -succinylhomoserine which expresses the polypeptide, and a method for producing O -succinylhomoserine using the same.
摘要翻译： 本发明涉及对甲硫氨酸的反馈抑制具有抵抗性并具有高丝氨酸O-琥珀酰转移酶活性的多肽，用于生产表达该多肽的O-琥珀酰高丝氨酸的微生物以及使用该微生物生产O-琥珀酰高丝氨酸的方法。
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9.发明公开MICROORGANISM PRODUCING O-ACETYL HOMOSERINE, AND METHOD FOR PRODUCING O-ACETYL HOMOSERINE BY USING MICROORGANISM 审中-公开O-乙酰高丝氨酸的微生物及其制备O-乙酰高丝氨酸的微生物方法
公开(公告)号：EP2998388A1
公开(公告)日：2016-03-23
申请号：EP15805095.5
申请日：2015-06-22
发明人： KIM, Hyun Ah , SEO, Ju Hee , SHIN, Yong Uk , KIM, So Young , KIM, Sang Kyoum , NA, Kwang Ho , BAE, Jee Yeon , SON, Sung Kwang , YOO, Hye Ryun , CHOI, Jin Geun
摘要： Disclosed is a microorganism of Escherichia sp. producing O -acetyl homoserine, and a method of producing O -acetyl homoserine in high yield using the microorganism.
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10.发明公开VARIANT POLYPEPTIDE HAVING HOMOSERINE ACETYLTRANSFERASE ACTIVITY AND MICROORGANISM EXPRESSING SAME 有权变种多糖多肽微量元素 - 乙酰胆碱酯酶维生素
公开(公告)号：EP2657250A2
公开(公告)日：2013-10-30
申请号：EP11852010.5
申请日：2011-12-21
发明人： KIM, So Young , SHIN, Yong Uk , SEO, Chang Il , HEO, In Kyung , KIM, Ju Eun , KIM, Hyun Ah , LEE, Han Jin , NA, Kwang Ho , SON, Sung Kwang
IPC分类号： C07K14/245 , C12N15/54 , C12N15/70 , C12P13/06 , C12R1/19
CPC分类号： C12N9/1029 , C12N1/00 , C12N15/70 , C12N15/74 , C12P13/06 , C12Y203/01031
摘要： The present invention relates to a polypeptide that is modified to have homoserine O-acetyltransferase activity, and in particular, the present invention provides a modified polypeptide having homoserine O-acetyltransferase activity, in which the amino acid at position 111 of a polypeptide having homoserine succinyltransferase activity is substituted with other amino acid.
摘要翻译： 本发明涉及被修饰为具有高丝氨酸O-乙酰转移酶活性的多肽，特别是本发明提供了具有高丝氨酸O-乙酰转移酶活性的修饰多肽，其中具有高丝氨酸琥珀酰转移酶的多肽的111位氨基酸 活性被其他氨基酸取代。
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