DEVELOPMENTS IN MENINGOCOCCAL OUTER MEMBRANE VESICLES
    5.
    发明公开
    DEVELOPMENTS IN MENINGOCOCCAL OUTER MEMBRANE VESICLES 审中-公开
    发展中的MENINGOCOCCAL外膜Vesics

    公开(公告)号:EP2613805A2

    公开(公告)日:2013-07-17

    申请号:EP11764868.3

    申请日:2011-09-09

    申请人: Novartis AG

    IPC分类号: A61K39/095 C12N1/00

    摘要: A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides meningococcal outer membrane vesicles in which NadA is over-expressed. A third aspect of the invention provides a panel of bacterial strains, each member of which is isogenic except for a single gene which in each strain encodes a different variant of an antigen of interest.

    摘要翻译: 本发明的第一方面提供了NHBA过表达的脑膜炎球菌外膜囊泡。 本发明的第二方面提供了其中NadA过度表达的脑膜炎球菌外膜囊泡。 本发明的第三方面提供了一组细菌菌株,其每个成员是同基因的,除了在每个菌株中编码感兴趣抗原的不同变体的单个基因。