公开(公告)号：EP2478466B1

公开(公告)日：2018-11-07

申请号：EP10816257.9

申请日：2010-09-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： HENG, Xin

IPC: G02B26/06 ,  A61N5/06 ,  A61B18/20 ,  G01N21/47 ,  G03H1/22 ,  G03H1/04 ,  A61B18/00 ,  G03H1/00

CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61B2018/00779 ,  G01N21/4795 ,  G01N2201/0675 ,  G02B26/06 ,  G03H1/0443 ,  G03H1/2294 ,  G03H2001/0072

Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.

公开(公告)号：EP2979122A1

公开(公告)日：2016-02-03

申请号：EP14723476.9

申请日：2014-03-22

Applicant: Gandolfi, Daniela ,  Mapelli, Jonathan ,  D'Angelo, Egidio ,  Pozzi, Paolo

Inventor： Gandolfi, Daniela ,  Mapelli, Jonathan ,  D'Angelo, Egidio ,  Pozzi, Paolo

IPC: G02B21/00 ,  G01N21/64

CPC classification number: G01N21/6458 ,  G01N2201/0675 ,  G02B21/004 ,  G02B21/0076

Abstract: A method of imaging a fluorescent sample comprising the steps of: scanning fluorescent points (9, 11) of said sample using scanner means (10, 8A, 88), thereby obtaining scanned fluorescent points; imaging said scanned fluorescent points on display means (12), said scanning comprising: predefining a scan field (2) for said sample, which comprises a set of scannable fluorescent points (9, 11); sequentially irradiating, using irradiation means (4, 8A, 8B), at least one first subset of points of said set of points and at least one second subset of said set of points, which complements said first subset with respect to said set of points. The first and second subsets can be irradiated at different focal irradiation distances (PI, P2).

公开(公告)号：EP2726849A4

公开(公告)日：2015-03-11

申请号：EP12806995

申请日：2012-06-12

Applicant: KLA TENCOR CORP

Inventor： KRISHNAN SHANKAR ,  WANG HAIMING

IPC: G01B11/06 ,  G01B11/30 ,  G01J3/02 ,  G01J3/42 ,  G01N21/21 ,  G01N21/55 ,  G03F7/20

CPC classification number: G01N21/55 ,  G01B11/065 ,  G01B2210/56 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/42 ,  G01N21/00 ,  G01N21/211 ,  G01N2021/213 ,  G01N2021/214 ,  G01N2201/0675

公开(公告)号：EP2150805B1

公开(公告)日：2013-11-27

申请号：EP08760262.9

申请日：2008-05-30

Applicant: The European Union, represented by the European Commission

Inventor： BEDNARKIEWICZ, Artur ,  WHELAN, Maurice

IPC: G01N21/64 ,  G02B21/16 ,  G02B21/36

CPC classification number: G01N21/6408 ,  G01N21/6458 ,  G01N2021/6423 ,  G01N2201/0675 ,  G02B21/16 ,  G02B21/365

公开(公告)号：EP1998165A1

公开(公告)日：2008-12-03

申请号：EP07109459.3

申请日：2007-06-01

Applicant: The European Community, represented by the European Commission

Inventor： Bednarkiewicz, Artur ,  Whelan, Maurice

IPC: G01N21/64 ,  G01J3/44 ,  G02B21/00

CPC classification number: G01N21/6408 ,  G01N21/6458 ,  G01N2021/6423 ,  G01N2201/0675 ,  G02B21/16 ,  G02B21/365

Abstract: Method of fluorescence imaging comprising:
a) illuminating a sample to excite its fluorescence and acquiring an image thereof;
b) based on spectral and spatial information from the sample's fluorescence image, segmenting the image into regions of similar spectral properties;
c) for each image segment, exciting the fluorescence of the corresponding sample region, and detecting the corresponding fluorescence;
d) based on modelling, determining expected fluorescence parameters from the fluorescence signals detected for each region;
e) scanning the sample and determining final fluorescence parameters based on said expected fluorescence parameters from step d).

Abstract translation: 荧光成像方法包括：a）照射样品以激发其荧光并获得其图像; b）基于来自样品荧光图像的光谱和空间信息，将图像分割成具有相似光谱性质的区域; c）对于每个图像段，激发相应样品区域的荧光，并检测相应的荧光; d）基于建模，根据为每个区域检测的荧光信号确定预期的荧光参数; e）基于来自步骤d）的所述预期荧光参数扫描样品并确定最终荧光参数。

公开(公告)号：EP2211219B1

公开(公告)日：2015-10-07

申请号：EP10151529.4

申请日：2010-01-25

Applicant: President and Fellows of Harvard College

Inventor： Xie, Xiaoliang Sunney ,  Freudinger, Christian ,  Min, Wei

IPC: G02B21/00 ,  G02B21/08 ,  G01H9/00 ,  G01J3/10 ,  G01J3/44 ,  G01N21/65

CPC classification number: G02B21/002 ,  G01J3/10 ,  G01J3/44 ,  G01J2003/1282 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/0675 ,  G02B21/082

公开(公告)号：EP2726849A2

公开(公告)日：2014-05-07

申请号：EP12806995.2

申请日：2012-06-12

Applicant: KLA-Tencor Corporation

Inventor： KRISHNAN, Shankar ,  WANG, Haiming

IPC: G01N21/25 ,  G01B11/24 ,  H01L21/66

CPC classification number: G01N21/55 ,  G01B11/065 ,  G01B2210/56 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/42 ,  G01N21/00 ,  G01N21/211 ,  G01N2021/213 ,  G01N2021/214 ,  G01N2201/0675

Abstract: A spectroscopic instrument for conducting multi-wavelength, multi-azimuth, multi-angle-of-incidence readings on a substrate, the instrument having a broadband light source for producing an illumination beam, an objective for directing the illumination onto the substrate at multiple azimuth angles and multiple angels-of-incidence simultaneously, thereby producing a reflection beam, an aperture plate having an illumination aperture and a plurality of collection apertures formed therein for selectively passing portions of the reflection beam having desired discreet combinations of azimuth angle and angle-of-incident, a detector for receiving the discreet combinations of azimuth angle and angle-of-incident and producing readings, and a processor for interpreting the readings.

公开(公告)号：EP2478466A4

公开(公告)日：2014-04-16

申请号：EP10816257

申请日：2010-09-14

Applicant: BIO RAD LABORATORIES

Inventor： HENG XIN

IPC: G03H1/00 ,  A61B18/00 ,  A61B18/20 ,  A61N5/06 ,  A61N5/067 ,  G01N21/47 ,  G02B26/06

CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61B2018/00779 ,  G01N21/4795 ,  G01N2201/0675 ,  G02B26/06 ,  G03H1/0443 ,  G03H1/2294 ,  G03H2001/0072

Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.

公开(公告)号：EP2480876A1

公开(公告)日：2012-08-01

申请号：EP10818176.9

申请日：2010-09-22

Applicant: Corporation De L'école Polytechnique De Montréal

Inventor： LESAGE, Frédéric ,  BÉLANGER, Samuel ,  ABRAN, Maxime ,  PROVOST, Jean

IPC: G01N21/49 ,  G01N21/64 ,  G01N21/76 ,  A61B6/00

CPC classification number: G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  G01N21/6456 ,  G01N21/763 ,  G01N2021/1787 ,  G01N2021/479 ,  G01N2201/0675

Abstract: A system and method for optical data acquisition of an illuminated turbid medium object, the system comprises a variable structured light detector and a controller. The light detector is adapted to retrieve light from a plurality of detection points of an output surface of the illuminated turbid medium object with a plurality of detection patterns. The controller is adapted to control the variable structured light detector for the variable structured light detector to use a detection pattern corresponding to an illumination pattern of the illuminated turbid medium object. The light detector is further adapted to optically measure a combination of retrieved light from the plurality of detection points as an optical measurement. The controller is further adapted to store an illumination pattern identifier indicative of the illumination pattern, a detection pattern identifier indicative of the detection pattern and the corresponding optical measurement.

公开(公告)号：EP0587020A3

公开(公告)日：1994-08-24

申请号：EP93113897.8

申请日：1993-08-31

Applicant: TEXAS INSTRUMENTS INCORPORATED

Inventor： Sampsell, Jeffrey B. ,  Bienstock, Rachelle J.

IPC: G01N21/88 ,  G02B27/46 ,  G06K9/74 ,  G06E3/00

CPC classification number: G06K9/745 ,  G01N21/95623 ,  G01N2201/0675 ,  G02B27/46 ,  G06E3/005

Abstract: An optical correlation unit (10) for correlating the images of an inspection object and a reference object. The unit uses two phase modulating reflective spatial light modulators (12a, 12b). A first spatial light modulator (12a) receives electronic input in the form of image data representing the inspection object. It modulates incoming light (15) with this input and reflects the modulated output to a first Fourier transform lens (13). This lens provides the optical input to second spatial light modulator (12b), whose electronic input is transform data presenting the complex conjugate of the Fourier transform of the reference image. The electronic input modulates the optical input, resulting in the Fourier product of the two images, which is then transformed to provide correlation data.