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    VIABILITY CELL COUNTING BY DIFFERENTIAL LIGHT ABSORPTION
    4.
    发明公开
    VIABILITY CELL COUNTING BY DIFFERENTIAL LIGHT ABSORPTION 有权
    COUNTING活细胞通过差别的光吸收

    公开(公告)号：EP2640843A1

    公开(公告)日：2013-09-25

    申请号：EP11841246.9

    申请日：2011-11-18

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： HENG, Xin ,  BRENIMAN, Eugene

    IPC: C12Q1/02 ,  G01N33/48

    CPC classification number: C12Q1/02 ,  G01N2015/1486

    Abstract: Cell counts that distinguish between live and dead cells while providing an accurate count of the total of live and dead cells are obtained by the use of a vital stain in conjunction with illumination of the cell population and the taking of light images at different wavelengths, one which is not absorbed by the stain and one that is absorbed by the stain. Masking and inaccuracies in the counting of dead cells is thereby avoided.

    NEAR REAL TIME OPTICAL PHASE CONJUGATION
    6.
    发明公开
    NEAR REAL TIME OPTICAL PHASE CONJUGATION 有权
    快速实时光相位共轭

    公开(公告)号：EP2478466A1

    公开(公告)日：2012-07-25

    申请号：EP10816257.9

    申请日：2010-09-14

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： HENG, Xin

    IPC: G06K9/00

    CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61B2018/00779 ,  G01N21/4795 ,  G01N2201/0675 ,  G02B26/06 ,  G03H1/0443 ,  G03H1/2294 ,  G03H2001/0072

    Abstract: An optical system and associated method enable near real time optical phase conjugation. In the method, a translucent medium is illuminated by a sample illumination beam. Light scattered by the medium is directed to an electronic image sensor while a reference beam is also directed to the electronic image sensor. The scattered light and the reference beam form an interference pattern at the electronic image sensor. A digital representation of the interference pattern is recorded using the electronic image sensor, and the characteristics of a conjugate of the sample beam are computed from the numerical representation. A conjugate beam having the computed characteristics is generated using a configurable optical element and directed back to the translucent medium. The generation of the conjugate beam may be accomplished using a spatial light modulator.

    COMPACT AUTOMATED CELL COUNTER
    7.
    发明公开
    COMPACT AUTOMATED CELL COUNTER 有权
    COMPACT自动细胞计数仪

    公开(公告)号：EP2473948A1

    公开(公告)日：2012-07-11

    申请号：EP10812708.5

    申请日：2010-08-30

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： McCOLLUM, Tom ,  PATT, Paul ,  SHEN, Frank ,  CHU, Daniel Y. ,  FLORY, Don ,  GRIFFIN, Mike ,  HENG, Xin ,  HEFNER, Eli

    IPC: G06K9/00 ,  C12M1/34

    CPC classification number: C12Q1/06 ,  G01N15/1434 ,  G02B21/0008 ,  G02B21/34

    Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2×2 mum or less and that images a field of view of at least 3 mm2. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm2. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

    LINE SCAN CYTOMETRY SYSTEMS AND METHODS
    8.
    发明公开
    LINE SCAN CYTOMETRY SYSTEMS AND METHODS 审中-公开
    扫描线ZYTOMETRIESYSTEME及其方法

    公开(公告)号：EP2678660A1

    公开(公告)日：2014-01-01

    申请号：EP12749439.1

    申请日：2012-02-21

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： HENG, Xin ,  PATT, Paul

    IPC: G01N21/00

    CPC classification number: G01N15/1459 ,  G01N15/1434 ,  G01N2015/144

    Abstract: Systems and methods for performing cytometry using a linear light sensor. An illumination field, a line scanned by the linear light sensor, or both are swept across a cell to be imaged. Relative motion between the cell and the swept illumination may be created using a movable optical component or components, by adhering cells to a plate and transporting the plate or by other techniques.

    HYBRID SINGLE MOLECULE IMAGING SORTER
    9.
    发明公开
    HYBRID SINGLE MOLECULE IMAGING SORTER 审中-公开
    HBYRIDSORTIERVORRICHTUNG用于单个分子的照片

    公开(公告)号：EP2659552A1

    公开(公告)日：2013-11-06

    申请号：EP11852463.6

    申请日：2011-12-30

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： HENG, Xin

    IPC: H01S3/00

    CPC classification number: G01N33/54366 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0454 ,  B01L2400/0487 ,  G01N15/1463 ,  G01N15/1484 ,  G01N21/6458 ,  G01N21/648 ,  G01N2021/6441 ,  Y10T436/143333

    Abstract: A system for characterizing and sorting individual molecules, for example chromatin or DNA molecules. In some configurations, the system can immobilize molecules of interest suspended in fluid in a sample stage for characterization, and selectively release the immobilized molecules to different output reservoirs, depending on the characterization result. For example, fluorescent markers may be hybridized onto molecules, which may then be attached to dielectric beads and immobilized using holographic optical tweezers or other means. The system may provide elongational flow to elongate molecules, and may detect the presence and spacing of multiple fluorescent markers hybridized to the molecules. Using advanced techniques, the system may be able to characterize features with a resolution better than the theoretical resolution of the system optics. The system may utilize a microfluidic cartridge.

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