公开(公告)号：EP3191885A1

公开(公告)日：2017-07-19

申请号：EP16708152.0

申请日：2016-03-07

申请人： Koninklijke Philips N.V.

发明人： BOAMFA, Marius Iosif ,  WIMBERGER-FRIEDL, Reinhold ,  HADDEMAN, Theodoor Bastiaan Johannes

IPC分类号： G02B21/00 ,  G02B21/36 ,  G02B3/00 ,  G01N21/64 ,  G02B21/08 ,  G02B21/16

CPC分类号： G02B21/0076 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6471 ,  G01N2021/6478 ,  G02B3/005 ,  G02B21/0032 ,  G02B21/0052 ,  G02B21/082 ,  G02B21/12 ,  G02B21/16 ,  G02B21/367

摘要： The present invention relates to digital pathology. In order provide enhanced use of available imaging radiation, a digital pathology scanner (10) is provided that comprises a radiation arrangement (12), a sample receiving device (14), an optics arrangement (16), and a sensor unit (18). The radiation arrangement comprises a source (20) that provides electromagnetic radiation (22) for radiating a sample received by the sample receiving device. Further, the optics arrangement comprises at least one of the group of a lens (24) and a filter (26) that are arranged between the sample receiving device and the sensor unit. The sensor unit is configured to provide image data of the radiated sample. Still further, a lens array arrangement (28) is provided that comprises at least one lens array (30) arranged between the source and the sample receiving device. The at least one lens array comprises a plurality of linear cylindrical lenses (32) that modulate the electromagnetic radiation from the source such that, in an object plane, a radiation distribution pattern (34) is generated with a plurality of first parts of intensified radiation and a plurality of second parts of weak radiation.

摘要翻译： 本发明涉及数字病理学。 为了提供对可用成像辐射的增强的使用，提供了包括辐射装置（12），样本接收装置（14），光学装置（16）和传感器单元（18）的数字病理扫描仪（10） 。 辐射装置包括提供用于辐射由样品接收装置接收的样品的电磁辐射（22）的源（20）。 此外，光学装置包括布置在样本接收装置和传感器单元之间的透镜组（24）和过滤器（26）的组中的至少一个。 传感器单元被配置为提供辐射样本的图像数据。 此外，提供了一种透镜阵列布置（28），其包括布置在源和样本接收装置之间的至少一个透镜阵列（30）。 所述至少一个透镜阵列包括多个线性柱面透镜（32），所述多个线性柱面透镜（32）调制来自所述源的电磁辐射，使得在物平面中产生具有多个增强辐射的第一部分的辐射分布图案（34） 和多个弱辐射的第二部分。

公开(公告)号：EP3074806A1

公开(公告)日：2016-10-05

申请号：EP13824322.5

申请日：2013-11-28

申请人： Femtonics Kft.

发明人： RÓZSA, Balázs József ,  KATONA, Gergely ,  MAÁK, Pál Andor

IPC分类号： G02B21/00 ,  G02B21/18

CPC分类号： G02B21/18 ,  A61B3/13 ,  A61B3/14 ,  A61B5/0071 ,  A61B5/40 ,  G02B21/0032 ,  G02B21/0052 ,  G02B21/0076

摘要： The invention relates to an optical microscope system (10) for the simultaneous measurement of at least two spatially distinct regions of interest, characterised by comprising at least two distinct optical measuring heads (12a, 12b, 12c) that can be simultaneously focused on spatially distinct arbitrary regions of interest, each optical measuring head is optically connectable with at least one scan head (14), the optical microscope system further comprising a control system (32) connected to the at least one scan head and the optical measuring head, the control system being configured to provide for synchronised control of the operation of the at least one scan head and the at least two optical measuring head.

公开(公告)号：EP0978009B1

公开(公告)日：2009-05-13

申请号：EP99914426.4

申请日：1999-02-22

申请人： Leica Microsystems CMS GmbH

发明人： ENGELHARDT, Johann

IPC分类号： G02B21/00

CPC分类号： G02B21/0052 ,  G02B21/0024 ,  G02B21/0056

公开(公告)号：EP1988825A2

公开(公告)日：2008-11-12

申请号：EP07763612.4

申请日：2007-02-08

申请人： The General Hospital Corporation

发明人： YUN, Seok-Hyun

IPC分类号： A61B5/00 ,  G01N21/63 ,  G01J3/44 ,  G01N21/17

CPC分类号： C07K14/70503 ,  A61B3/102 ,  A61B3/117 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0095 ,  A61B5/0097 ,  A61B5/4088 ,  A61B5/412 ,  A61B5/413 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/70 ,  G01B9/02091 ,  G01J3/4412 ,  G01N21/1717 ,  G01N21/4795 ,  G01N21/636 ,  G01N2021/1725 ,  G01N2021/638 ,  G01N2201/06 ,  G01N2201/0612 ,  G01N2800/042 ,  G01N2800/387 ,  G01N2800/7023 ,  G01N2800/7028 ,  G02B21/0052

摘要： Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between -100 GHz and 100 GHz, excluding zero.

公开(公告)号：EP1714109B1

公开(公告)日：2007-07-25

申请号：EP05707841.2

申请日：2005-01-25

申请人： SIEMENS AKTIENGESELLSCHAFT

发明人： SCHICK, Anton

IPC分类号： G01B11/02 ,  G01B11/06 ,  G01B11/24 ,  G01B11/30 ,  G01B21/20 ,  G02B21/00

CPC分类号： G01S7/4818 ,  G01B11/026 ,  G01C3/26 ,  G01S17/08 ,  G01S17/87 ,  G02B21/0052

摘要： The invention concerns a confocal distance sensor (300) comprising the following components: an optical component (313) in the form of a point both for sending an illuminating light (314) and for receiving a measuring light (315); a reproduction optics (320) for focusing the illuminating light (314) in the region of an object and for focusing the measuring light (75) reflected by the object surface in the region surrounding the optical component (313); a displacement device (322) for varying the optical path between the optical element (313) and the reproduction optics (320). The invention is characterized in that the displacement device (322) is designed to move directly the optical component (313) relative to the reproduction optics (320), such that the illuminating light (314) emitted by the optical component (313) is directly incident on the reproduction optics (320). The optical component (313) is preferably made of one end of an optical fiber (310). The invention is useful for producing an optical distance sensor with multiple channels, several optical fiber ends being arranged in a one-dimensional or two-dimensional grid and moved together or separately relative to a single reproduction optics.

公开(公告)号：EP1122575A3

公开(公告)日：2004-01-02

申请号：EP01101475.0

申请日：2001-01-24

申请人： Leica Microsystems Heidelberg GmbH

发明人： Engelhardt, Johann, Dr.

IPC分类号： G02B21/26 ,  G02B21/00 ,  G02B7/00

CPC分类号： G02B21/0052 ,  G02B7/00 ,  G02B7/005

摘要： Eine Vorrichtung zum Positionieren eines optischen Bauteils (1) in einem Strahlengang (2), vorzugsweise im Strahlengang (2) eines Mikroskops, insbesondere eines konfokalen Rastermikroskops, wobei mehrere optische Bauteile (1) in einer Fassung (3) justiert angeordnet sind, ist dadurch gekennzeichnet, dass die Fassung (3) als Magazin (3) in einem im Strahlengang (2) positionierten, einen Durchgang (4) für den Strahlengang (2) aufweisenden Führungsblock (5) geführt ist. Weiterhin ist zum einfachen, schnellen und präzisen Austausch der optischen Elemente unter Vermeidung einer stets erforderlichen Justage der optischen Bauteile eine Vorrichtung zum Positionieren eines optischen Bauteils in einem Strahlengang (2), vorzugsweise im Strahlengang eines Mikroskops, insbesondere eines konfokalen Rastermikroskops, dadurch gekennzeichnet, dass das optische Bauteil als ein monolithisches Substrat (19) mit Bereichen unterschiedlicher optischer Eigenschaften ausgebildet ist und in einem im Strahlengang (2) positionierten, einen Durchgang (4) für den Strahlengang (2) aufweisenden Führungsblock (5) geführt ist.

摘要翻译： 形成在光学部件（1）上的光学活性表面（6）位于平行于安装件（3）的引导表面（7）的平面上。 引导块（5）具有沿着光束路径（2）形成的开口（4）。 光学部件设置在安装座上。 共焦扫描显微镜还包括一个独立的权利要求。

公开(公告)号：EP1145067B1

公开(公告)日：2002-09-04

申请号：EP00900715.4

申请日：2000-01-17

申请人： ISIS INNOVATION LIMITED

发明人： WILSON, Tony ,  NEIL, Mark Andrew Aquilla ,  JUSKAITIS, Rimvydas

IPC分类号： G02B21/00

CPC分类号： G02B21/0076 ,  G02B21/0024 ,  G02B21/0052 ,  G02B21/0056 ,  G02B21/0068 ,  G02B21/0084

摘要： The confocal microscope has two matched light sources: a first light source (1) and a second light source (8). The light sources (1,8) are arranged to illuminate opposite sides of a modulating mask (6). The light either reflecting from or passing through the modulating mask (6) is then used to illuminate an object O supported on a mount (5). The microscope is arranged so that the object O is mounted on the opposite side of the mask (6) to a camera (7) such that light reflected from the object O passes through the modulating mask (6) before being captured by the camera (7). Subtraction of the image produced using the second light source (8) from the image produced using the first light source (1) generates a confocal image that contains substantially less noise than is possible with available confocal microscopy apparatus.

公开(公告)号：EP1168029A3

公开(公告)日：2002-06-12

申请号：EP00116790.7

申请日：2000-08-03

申请人： Yokogawa Electric Corporation ,  VisiTech International Ltd.

发明人： Kawamura, Shinichirou, c/o Yokogawa Electric Corp. ,  Negishi, Hideomi, c/o Yokogawa Electric Corporat. ,  Tomosada, Nobuhiro, c/o Yokogawa Electric Corp. ,  Ootsuki, Shinya, c/o Yokogawa Electric Corporation ,  Shelbee, Jafer, c/o Visitech International, Ltd. ,  Bell, Kenneth, c/o Visitech International, Ltd.

IPC分类号： G02B21/00

CPC分类号： G02B21/0044 ,  G02B21/0052

摘要： To provide an optical image separation system, connected to the confocal image output port of a Nipkow disk type confocal scanner, the system being capable of detecting the light returned from a sample and emitted from the above confocal image output port by separating the return light into a plurality of different wavelength regions respectively, and of holding the throughput high without increasing the cost. Optical image separation system 300 is realized, which is provided with a dichroic mirror or dichroic mirrors 30 (return light separating means) that separates return light 7 from sample 60, emitted from confocal image output port 110 of confocal scanner 100.

公开(公告)号：EP2620762B1

公开(公告)日：2017-02-01

申请号：EP11826797.0

申请日：2011-09-16

申请人： Olympus Corporation

发明人： TANABE, Tetsuya

IPC分类号： G02B21/00 ,  G01N15/14 ,  G01N21/64

CPC分类号： G01N21/85 ,  G01N15/1434 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/1087 ,  G02B21/0052 ,  G02B21/0076 ,  G02B21/008

公开(公告)号：EP2064578A1

公开(公告)日：2009-06-03

申请号：EP07788340.3

申请日：2007-08-09

申请人： Leica Microsystems CMS GmbH

发明人： SIECKMANN, Frank

IPC分类号： G02B21/36

CPC分类号： G02B21/367 ,  G01N1/312 ,  G02B21/0052 ,  G02B21/244

摘要： A method for examining a specimen using a microscope, in particular a confocal scanning microscope, has the following steps. First, a scanning region, containing a specimen to be examined or a plurality of specimens to be examined, in a predeterminable spatial direction is selected. Then, a series of images in the scanning region along the spatial direction are recorded such that the individual images can be uniquely assigned to individual planes in the spatial direction. Then, an image analysis method is selected with at least one predeterminable criterion with respect to the specimen to be examined or the specimens to be examined. Finally, the image analysis method is applied to the individual planes for ascertaining a preferred plane which at least to a great extent satisfies the predeterminable criterion or criteria. Furthermore, a microscope for carrying out the method is specified.