公开(公告)号：EP0941981A4

公开(公告)日：2003-07-02

申请号：EP97937862

申请日：1997-09-01

申请人： TAKARA BIO INC

发明人： KOYAMA NOBUTO ,  SAGAWA HIROAKI ,  KOBAYASHI EIJI ,  ENOKI TATSUJI ,  WU HUA-KANG ,  NISHIYAMA EIJI ,  IKAI KATSUSHIGE ,  KATO IKUNOSHIN

IPC分类号： A23L1/30 ,  A61K8/35 ,  A61K8/60 ,  A61K31/12 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q19/00 ,  C07C45/67 ,  C07C49/707 ,  C07H7/033 ,  A01N35/06 ,  A61K7/00 ,  A61K7/50 ,  C07C45/00 ,  C07C45/59 ,  C07C45/78

CPC分类号： C07H7/033 ,  A61K8/35 ,  A61K8/60 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/00 ,  A61Q19/10

摘要： A process for preparing 4,5-dihydroxy-2-cyclopenten-1-one represented by formula (1), characterized by heat-treating at least one member selected among: (a) uronic acids or uronic acid derivatives; (b) sugar compounds containing uronic acids and/or uronic acid derivatives; and (c) sugar compound-containing materials containing uronic acids and/or uronic acid derivatives.

公开(公告)号：EP1306387A4

公开(公告)日：2005-07-06

申请号：EP01947980

申请日：2001-07-12

申请人： TAKARA BIO INC

发明人： WU HUA-KANG ,  SAKAI TAKESHI ,  ADACHI SHINICHI ,  YASUDA MARIKO ,  KATO IKUNOSHIN

IPC分类号： A61K8/49 ,  A61K8/73 ,  A61K31/737 ,  A61K36/03 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/08 ,  C08B37/00 ,  A61K7/00 ,  A61K35/56 ,  A61K35/80

CPC分类号： C08B37/00 ,  A61K8/73 ,  A61K31/737 ,  A61K35/36 ,  A61K36/03 ,  A61Q19/00 ,  A61Q19/08

摘要： Drugs to be used as remedies or preventives for diseases wherein the production of beta -transforming growth factor should be enhanced, agents for ameliorating or preventing wrinkles, agents for elevating or sustaining skin elasticity, agents for ameliorating or preventing skin thickening, or agents for preventing collagen reduction or enhancing collagen production; and cosmetics to be used for enhancing the production of beta -transforming growth factor, ameliorating or preventing wrinkles, elevating or sustaining skin elasticity, ameliorating or preventing skin thickening, or preventing collagen reduction or enhancing collagen production, etc. These drugs/cosmetics are characterized by containing, as the active ingredient, at least one member selected from the group consisting of fucoidan, its decomposition products and salts thereof.

公开(公告)号：EP1170007A4

公开(公告)日：2004-12-15

申请号：EP00902942

申请日：2000-02-14

申请人： TAKARA BIO INC

发明人： OHNOGI HIROMU ,  AKIYAMA KAORI ,  TOMINAGA TAKANARI ,  NISHIYAMA EIJI ,  WU HUA-KANG ,  TATSUMI YOKO ,  SAGAWA HIROAKI ,  KATO IKUNOSHIN

IPC分类号： A23L1/015 ,  A23L1/0522 ,  A23L1/0532 ,  A23L1/09 ,  A23L1/29 ,  A23L2/52 ,  A61K8/70 ,  A61K8/73 ,  A61K31/122 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715 ,  A61K31/737 ,  A61P1/16 ,  A61P3/10 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  A61Q19/00 ,  A23L1/30 ,  A23L2/00

CPC分类号： A61K31/737 ,  A23L2/52 ,  A23L5/273 ,  A23L29/219 ,  A23L29/256 ,  A23L29/30 ,  A23L29/37 ,  A23L33/00 ,  A61K31/122 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715

摘要： Remedies or preventives for diseases with a need for the reinforcement of the production of growth factor and/or diseases with a need for the reinforcement of the production of interleukin-12, characterized by containing as the active ingredient a compound selected from among 4,5-dihydroxy-2-cyclopenten-1-one represented by formula (I), 4-hydroxy-2-cyclopenten-1-one and derivatives thereof.

摘要翻译： 需要增强生长因子和/或疾病的生产的疾病的补救或预防，需要增强白细胞介素-12的产生，其特征在于包含选自以下的化合物作为活性成分：4,5 由式（I）表示的4-羟基-2-环戊烯-1-酮，4-羟基-2-环戊烯-1-酮及其衍生物。

公开(公告)号：EP1166786A4

公开(公告)日：2004-05-12

申请号：EP00900419

申请日：2000-01-18

申请人： TAKARA BIO INC

发明人： ENOKI TATSUJI ,  SAGAWA HIROAKI ,  TOMONO JUN ,  TOMINAGA TAKANARI ,  NISHIYAMA EIJI ,  WU HUA-KANG ,  KATO IKUNOSHIN

IPC分类号： A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7024 ,  A61K31/7028 ,  A61P3/10 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07H3/10 ,  C07H11/00 ,  C07H15/04 ,  A23L1/30 ,  C08B37/00

CPC分类号： A61K31/7048 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/7024 ,  A61K31/7028 ,  C07H3/10 ,  C07H11/00 ,  C07H15/04 ,  Y10S977/915

摘要： Medicinal compositions for treating or preventing diabetes, rheumatoid, diseases wherein inflammation should be inhibited, diseases wherein alpha -glycosidase should be inhibited, diseases wherein the synthesis of prostaglandin should be inhibited, diseases wherein endotoxin shock should be inhibited, diseases wherein the production of interleukin should be inhibited, diseases wherein the production of heme oxygenase should be induced, and diseases wherein the production of tumor necrosis factor or carcinogenesis should be inhibited, which contain as the active ingredient at least one compound selected from the group consisting of 3,6-anhydrogalactopyranose represented by formula (I), its aldehyde, its hydrate and 2-O-methylated derivatives and 2-O-sulfated derivatives thereof.

公开(公告)号：EP1050525A4

公开(公告)日：2003-09-17

申请号：EP99900318

申请日：1999-01-14

申请人： TAKARA BIO INC

发明人： TATSUMI YOKO ,  SAGAWA HIROAKI ,  OHNOGI HIROMU ,  KOBAYASHI EIJI ,  WU HUA-KANG ,  KOYAMA NOBUTO ,  IKAI KATSUSHIGE ,  KATO IKUNOSHIN

IPC分类号： A23L1/30 ,  A61K31/11 ,  A61K31/122 ,  A61K31/198 ,  A61K31/351 ,  A61K31/357 ,  A61K31/52 ,  C07C323/22 ,  C07C323/60 ,  C07D473/00 ,  C07C47/263 ,  A23L2/00 ,  A61K31/12 ,  C07C45/52 ,  C07C45/59 ,  C07C49/707 ,  C07D473/18 ,  C07D473/34

CPC分类号： A61K31/7004 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/11 ,  A61K31/122 ,  A61K31/198 ,  A61K31/351 ,  A61K31/357 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  A61K31/711 ,  C07C323/22 ,  C07C323/60 ,  C07C2601/08 ,  C07D473/00 ,  A23V2250/60 ,  A23V2250/638 ,  A23V2250/626

摘要： A process for producing substances capable of inducing apoptosis characterized by involving the step of heating at least one compound selected from among the following compounds (a) to (d), provided that uronic acid and/or uronic acid derivatives and compounds containing uronic acid and/or uronic acid derivatives are excluded therefrom: (a) pentoses; (b) pentose derivatives; (c) compounds containing pentoses; and (d) compounds containing pentose derivatives.

公开(公告)号：EP0888776A4

公开(公告)日：2005-01-26

申请号：EP97904630

申请日：1997-02-25

申请人： TAKARA BIO INC

发明人： KOYAMA NOBUTO ,  SAGAWA HIROAKI ,  KOBAYASHI EIJI ,  ENOKI TATSUJI ,  WU HUA-KANG ,  NISHIYAMA EIJI ,  DEGUCHI SUZU ,  IKAI KATSUSHIGE ,  OHNOGI HIROMU ,  UEDA MOTOKO ,  KONDO AKIHIRO ,  KATO IKUNOSHIN

IPC分类号： A23L3/3562 ,  A61K8/60 ,  A61K31/19 ,  A61K31/70 ,  A61K31/7012 ,  A61K31/715 ,  A61K31/727 ,  A61K31/728 ,  A61K31/732 ,  A61K31/734 ,  A61K31/737 ,  A61K35/00 ,  A61K35/12 ,  A61K35/74 ,  A61K36/00 ,  A61L2/16 ,  A61P35/00 ,  A61Q11/00 ,  C07H7/033 ,  C07C49/707 ,  A01N35/06 ,  A23L1/30 ,  A61K7/00 ,  A61K7/50 ,  A61K31/12 ,  C07C45/00 ,  C07C45/59 ,  C07C45/67 ,  C07C45/78 ,  C08B37/00

CPC分类号： C07H7/033 ,  A61K8/60 ,  A61Q11/00 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

摘要： A product of heat treatment of at least one member selected from among (a) uronic acid or uronic acid derivatives, (b) a saccharide containing uronic acid or uronic acid derivatives, and (c) a substance comprising a saccharide containing uronic acid or uronic acid derivatives; and food, drink or drug characterized by containing this product.

公开(公告)号：EP1175907A4

公开(公告)日：2004-12-29

申请号：EP00917309

申请日：2000-04-14

申请人： TAKARA BIO INC

发明人： SAGAWA HIROAKI ,  SAKAI TAKESHI ,  KOBAYASHI EIJI ,  LI TUO-PING ,  OHNOGI HIROMU ,  NISHIMURA KAORI ,  NISHIYAMA EIJI ,  WU HUA-KANG ,  MIZUTANI SHIGETOSHI ,  KATO IKUNOSHIN

IPC分类号： A23K1/16 ,  A23L1/0522 ,  A23L1/0532 ,  A23L1/09 ,  A23L1/29 ,  A23L2/52 ,  A61K8/60 ,  A61K8/70 ,  A61K8/73 ,  A61K31/122 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715 ,  A61K31/737 ,  A61P43/00 ,  A61Q19/00 ,  A61K7/40 ,  C08B37/00

CPC分类号： A61K8/60 ,  A23K20/163 ,  A23L2/52 ,  A23L29/219 ,  A23L29/256 ,  A23L29/30 ,  A23L29/37 ,  A23L33/00 ,  A61K8/73 ,  A61K8/732 ,  A61K31/122 ,  A61K31/70 ,  A61K31/7016 ,  A61K31/702 ,  A61K31/715 ,  A61K31/737 ,  A61Q19/00

摘要： The present invention provides a therapeutic agent or prophylactic agent for a disease requiring induction of growth factor production, a food, beverage or feed for induction of growth factor production, a cosmetic for induction of growth factor production, and a controlling agent for growth factor production, characterized in that each comprises as an effective ingredient a compound selected from the group consisting of acidic polysaccharides, degradation products thereof, acidic oligosaccharides, acidic monosaccharides, acidic sugar alcohols and salts thereof, wherein the compound has induction action for growth factor production.

公开(公告)号：EP0984001A4

公开(公告)日：2004-12-08

申请号：EP98905688

申请日：1998-02-26

申请人： TAKARA BIO INC

发明人： KOYAMA NOBUTO ,  ENOKI TATSUJI ,  IKAI KATSUSHIGE ,  WU HUA-KANG ,  OHNOGI HIROMU ,  TOMINAGA TAKANARI ,  NISHIYAMA EIJI ,  HAGIYA MICHIO ,  SAGAWA HIROAKI ,  CHONO HIDETO ,  KATO IKUNOSHIN

IPC分类号： A23K1/16 ,  A23L1/30 ,  A23L2/52 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  C07C323/59 ,  C07C323/50 ,  A61K31/10 ,  A61K31/12 ,  A61K31/195 ,  C07C323/17 ,  C07C323/22 ,  C07K5/02

CPC分类号： C07C323/59 ,  A23K20/105 ,  A23L2/52 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/122 ,  C07C45/60 ,  C07C45/78 ,  C07C49/707 ,  C07C323/58 ,  C07C2601/08 ,  A23V2200/224 ,  A23V2250/5026 ,  A23V2250/5024 ,  A23V2250/70 ,  A23V2250/204 ,  A23V2250/06 ,  A23V2250/21

摘要： A compound represented by the following formula ÄIÜ or an optically active substance or a salt thereof. (In the formula, a bond shown by a dotted line in the five-membered ring means that said five-membered ring may be any of a cyclopentene ring having a double bond and a cyclopentane ring where said bond is saturated and, in the case of a cyclopentene ring, X is OH, Y is =O and Z is H while, in the case of a cyclopentane ring, X is =O, Y is OH and Z is OH. R is a residue after removal of an SH group from the SH-containing compound.)

摘要翻译： 由通式（I）表示的化合物，其光学活性异构体或任一种的盐，其中五元环中由虚线表示的键表示五元环为不饱和环戊烯环或饱和环戊烷 当它是环戊烯环时，则X是OH，Y是= O，并且Z是H，而当它是环戊烷环时，则X是= O，Y是OH，并且Z是OH; R是通过除去SH基团而由具有SH基团的化合物形成的残基。