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    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    1.
    发明公开
    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 审中-公开

    公开(公告)号：EP4321615A2

    公开(公告)日：2024-02-14

    申请号：EP23201197.3

    申请日：2010-04-30

    Applicant: Genomatica, Inc.

    Inventor： Burgard, Anthony P. ,  Burk, Mark J. ,  Osterhout, Robin E. ,  Pharkya, Priti

    IPC: C12N9/04

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient account to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacelyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    2.
    发明公开
    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 审中-公开
    用于生产1,3-丁二醇的有机物

    公开(公告)号：EP3318626A1

    公开(公告)日：2018-05-09

    申请号：EP17188529.6

    申请日：2010-04-30

    Applicant: Genomatica, Inc.

    Inventor： Burgard, Anthony P. ,  Burk, Mark J. ,  Osterhout, Robin E. ,  Pharkya, Priti

    IPC: C12N1/21 ,  C12P7/18 ,  C12N9/04

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

    Abstract translation: 非天然存在的微生物有机体包括具有1,3-丁二醇（1,3-BDO）途径的微生物，所述微生物具有至少一种编码1,3-BDO途径酶的外源核酸，所述1,3-BDO途径酶以足以产生1 ，3-BDO。 该途径包括选自2-氨基-4-酮戊酸（AKP）硫解酶，AKP脱氢酶，2-氨基-4-羟基戊酸转氨酶，2-氨基-4-羟基戊酸酯氧化还原酶（脱氨基），2-氨基-4-羟基戊酸酯氧化还原酶 4-羟基戊酸脱羧酶，3-羟基丁醛还原酶，AKP氨基转移酶，AKP氧化还原酶（脱氨基），2,4-二氧代戊酸脱羧酶，3-氧代丁醛还原酶（酮还原），3-氧代丁醛还原酶（醛还原 ），4-羟基-2-丁酮还原酶，AKP脱羧酶，4-氨基丁-2-酮转氨酶，4-氨基丁-2-酮氧化还原酶（脱氨基），4-氨基丁-2-酮氨裂解酶 ，丁烯酮水合酶，AKP氨裂解酶，乙酰基丙烯酸酯脱羧酶，乙酰乙酰-CoA还原酶（CoA依赖性，醛形成），乙酰乙酰-CoA还原酶（CoA依赖性，形成醇），乙酰乙酰-CoA还原酶（酮 还原），3-羟基丁酰-CoA还原酶（醛形成），3-羟基丁醛 Yryl-CoA还原酶（形成醇），4-羟基丁酰-CoA脱水酶和巴豆酸酶。 生产1,3-BDO的方法包括在一定条件下培养这些微生物并持续足够的时间以产生1,3-BDO。

    MICROORGANISMS FOR PRODUCING 4C-5C COMPOUNDS WITH UNSATURATION AND METHODS RELATED THERETO
    4.
    发明公开
    MICROORGANISMS FOR PRODUCING 4C-5C COMPOUNDS WITH UNSATURATION AND METHODS RELATED THERETO 审中-实审

    公开(公告)号：EP4389904A2

    公开(公告)日：2024-06-26

    申请号：EP24159396.1

    申请日：2015-07-02

    Applicant: Genomatica, Inc.

    Inventor： Culler, Stephanie J. ,  Burk, Mark J. ,  Osterhout, Robin E. ,  Pharkya, Priti

    IPC: C12P7/40

    CPC classification number: C12N15/52 ,  C12P5/026 ,  C12P7/40 ,  C12P7/04 ,  Y02E50/30

    Abstract: The invention provides a non-naturally occurring microbial organism having a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-l-ol, pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a pathway. The invention additionally provides a method for producing butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-l-ol,. The method can include culturing a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a pathway enzyme in a sufficient amount, and under conditions and for a sufficient period of time to produce butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-l-ol.

    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
    6.
    发明公开
    ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 审中-公开

    公开(公告)号：EP3686272A1

    公开(公告)日：2020-07-29

    申请号：EP19212136.6

    申请日：2010-04-30

    Applicant: Genomatica, Inc.

    Inventor： Burgard, Anthony P. ,  Burk, Mark J. ,  Osterhout, Robin E. ,  Pharkya, Priti

    IPC: C12N1/21 ,  C12P7/18 ,  C12N9/04

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA-dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

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