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    BETA-ELEMENE VINYLATION COUPLED DERIVATIVE, AND PREPARATION THEREOF AND USE THEREOF IN PREPARATION OF ANTITUMOR DRUG
    6.
    发明公开
    BETA-ELEMENE VINYLATION COUPLED DERIVATIVE, AND PREPARATION THEREOF AND USE THEREOF IN PREPARATION OF ANTITUMOR DRUG 审中-公开

    公开(公告)号：EP4276087A1

    公开(公告)日：2023-11-15

    申请号：EP22924566.7

    申请日：2022-11-17

    申请人： Hangzhou Normal University

    发明人： XIE, Tian ,  YE, Yang ,  XU, Bing ,  YE, Xiangyang

    IPC分类号： C07C43/215 ,  C07C41/30 ,  C07C69/767 ,  C07B37/00 ,  A61K31/085 ,  A61K31/277

    摘要： The present disclosure provides a vinylation coupled derivative of β-elemene, and a preparation method and use thereof in preparation of an antitumor drug. The present disclosure provides a vinylation coupled derivative of β-elemene having a structure shown in Formula (I), a pharmaceutical composition and a hydrate including a compound shown in Formula (I), as well as an isotopic derivative, a chiral isomer, a variant, a salt, a prodrug, and a preparation of the compound shown in Formula (I). The present disclosure further provides a preparation method and use of the vinylation coupled derivative of β-elemene, and an inhibitory activity of the derivative on proliferation of various tumor cell lines. The vinylation coupled derivative of β-elemene is expected to be an antitumor drug candidate for treating colon cancer and lung cancer.