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    TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM
    8.
    发明公开
    TREATMENT OF MALE ANDROGEN DEFICIENCY SYMPTOMS OR DISEASES WITH SEX STEROID PRECURSOR COMBINED WITH SERM 审中-公开
    BEHANDLUNG VONMÄNNLICHENANDROGENMANGELSYMPTOMEN ODER -ERKRANKUNGEN MITSEXSTEROIDVORLÄUFERN在KOMBINATION MIT SERMERM

    公开(公告)号：EP3116510A4

    公开(公告)日：2017-08-16

    申请号：EP15761680

    申请日：2015-03-09

    申请人： ENDORECHERCHE INC

    发明人： LABRIE FERNAND ,  GAUTHIER SYLVAIN

    IPC分类号： A61K31/5685 ,  A61K31/352 ,  A61P5/26 ,  A61P5/32 ,  C07D311/60 ,  C07J1/00

    CPC分类号： A61K31/5685 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/453 ,  A61K38/24 ,  A61K45/06 ,  A61K2300/00

    摘要： Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low DHEA or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (DHEA) and a selective estrogen receptor modulator (SERM) (particularly acolbifene), an antiestrogen or a prodrug of the two. The symptoms or diseases are loss of libido, erectile dysfunction, tiredness, loss of energy, depression, bone loss, muscle loss, muscle weakness, fat accumulation, memory loss, cognition loss, Alzheimer's disease, dementia, loss of body hair, fertility problems, insomnia, gynecomastia, anemia, hot flushes, sweats, decreased sense of well-being, obesity, osteoporosis, hypercholesterolemia, hyperlipidemia, atherosclerosis, hypertension, insulin resistance, cardiovascular disease and type 2 diabetes. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed.

    摘要翻译： 包括人类在内的包括人在内的预防，减少或消除男性雄激素缺乏症状或疾病包括男性性腺功能减退症相关症状和与低血清睾酮和/或低DHEA或低总雄激素相关疾病发病率的新方法 一定量的性类固醇前体，特别是脱氢表雄酮（DHEA）和选择性雌激素受体调节剂（SERM）（特别是阿考比芬），这两者的抗雌激素或前药。 症状或疾病是性欲减退，勃起功能障碍，疲倦，精力不集中，抑郁症，骨质流失，肌肉损失，肌肉无力，脂肪堆积，记忆丧失，认知丧失，阿尔茨海默病，痴呆，体毛脱落，生育问题 ，失眠，男子女性型乳房，贫血，热潮红，汗水，幸福感减退，肥胖，骨质疏松症，高胆固醇血症，高脂血症，动脉粥样硬化，高血压，胰岛素抵抗，心血管疾病和2型糖尿病。 还公开了用于递送用于本发明的活性成分和试剂盒的药物组合物。