公开(公告)号：EP3713608A1

公开(公告)日：2020-09-30

申请号：EP18881023.8

申请日：2018-11-21

申请人： Ash Access Technology, Inc.

发明人： ASH, Stephen, R.

IPC分类号： A61L2/18 ,  A61L29/14 ,  A61L29/16 ,  A01N31/02 ,  A01N37/02 ,  C07C33/18

公开(公告)号：EP2215069B1

公开(公告)日：2011-07-06

申请号：EP08841678.9

申请日：2008-10-20

申请人： Firmenich S.A.

发明人： FEHR, Charles

IPC分类号： C07D307/79 ,  C07C33/18 ,  C07C47/235 ,  A61K8/49

CPC分类号： C07D307/79 ,  C07C33/14 ,  C07C45/512 ,  C07C47/225 ,  C07C2602/10

摘要： The present invention concerns a process for the preparation of a compound of formula (I), wherein the dotted line is a single bond and n is 1 or the dotted line is a double bond and n is 0, and wherein the relative configuration is as shown, in the form of any one of its diastereoisomers or enantiomers or mixtures thereof.

公开(公告)号：EP1719746A4

公开(公告)日：2009-04-15

申请号：EP05710698

申请日：2005-02-18

申请人： ZEON CORP

发明人： NEMOTO HISAO

IPC分类号： C07B57/00 ,  C07C29/88 ,  C07C31/125 ,  C07C33/03 ,  C07C33/18 ,  C07C33/20 ,  C07C45/29 ,  C07C67/60 ,  C07C69/68 ,  C07D307/935

CPC分类号： C07B57/00 ,  C07C45/294 ,  C07D307/935 ,  C07C49/697

摘要： An optical resolver comprising a bicycle[3.3.0]-2-oxaoctane compound represented by the formula [1], [2], or [3]; a process for producing an optically active isomer which comprises reacting the optical resolver with a mixture of optically active monomers having active hydrogen to obtain a diastereomer mixture, separating the diastereomer mixture into the diasteromers, and then decomposing either of these to obtain an optically active (R) or (S) isomer; and the compound in which R11 is fluorenylmethyl, fluorenylidenemethyl, bis(4-cyclohexylphenyl)methyl, 4-(9-phenanthryl)phenyl, 4-(1-pyrenyl)phenyl, 4-(5-acenaphthenyl)phenyl, or 4-(9-anthryl)phenyl. Use of the optical resolver enables an optically active isomer which has an extremely high purity and is useful to be efficiently produced.

公开(公告)号：EP1719746A1

公开(公告)日：2006-11-08

申请号：EP05710698.1

申请日：2005-02-18

申请人： ZEON CORPORATION

发明人： NEMOTO, Hisao

IPC分类号： C07B57/00 ,  C07C29/88 ,  C07C31/125 ,  C07C33/03 ,  C07C33/18 ,  C07C33/20 ,  C07C67/60 ,  C07C69/68 ,  C07D307/935

CPC分类号： C07B57/00 ,  C07C45/294 ,  C07D307/935 ,  C07C49/697

摘要： An agent for optical resolution comprising a bicyclo [3.3.0] -2-oxaoctane compound represented by the formula [1], [2] or [3] ; a process for producing an optically active substance comprising obtaining a mixture of diastereomers by reaction of the agent with a mixture of optically active substances having active hydrogen atom, resolving the mixture of diastereomers into each diastereomer and obtaining an (R) optically active substance or an (S) optically active substance by decomposition of the diastereomer; and compounds represented by the above formulae in which R 11 represents fluorenylmethyl group, fluorenylidenemethyl group, bis(4-cyclohexylphenyl)methyl group, 4-(9-phenanthryl)phenyl group, 4-(1-pyrenyl)phenyl group, 4-(5-acenaphthenyl)phenyl group or 4-(9-anthryl)phenyl group, are disclosed. A useful optically active substance having a very high purity can be produced efficiently by using the agent of the present invention.

摘要翻译： 光学拆分的试剂，其包括由下式表示的双环[3.3.0] -2- oxaoctane化合物[1]，[2]或[3]; 在光学活性物质，其包括由所述试剂的反应与具有活性氢原子的光学活性物质的混合物获得非对映体混合物制备，非对映体的混合物拆分成各非对映体和（R）获得光学活性体或一种方法 （S）由非对映体的分解光学活性物质; 和由其中R 11 darstellt芴基，fluorenylidenemethyl基，（二（4-己基苯基）甲基，4-（9-菲基）苯基，4-（1-芘基）苯基，4-以上式表示的化合物 5-苊基）苯基或4-（9-蒽基）苯基，是游离缺失盘。 具有非常高纯度的有用的光学活性物质可有效地使用本发明的药剂来制造。

公开(公告)号：EP1086941B1

公开(公告)日：2005-08-17

申请号：EP00906640.8

申请日：2000-03-02

申请人： TOKUYAMA CORPORATION

发明人： Iwasaki, Fumiaki ,  Tanaka, Kenji ,  Matsumura, Yoshihiro ,  Onomura, Osamu

IPC分类号： C07C29/14 ,  C07C29/143 ,  C07C31/02 ,  C07C31/133 ,  C07C33/18 ,  C07C35/02 ,  C07C35/21 ,  C07C209/52 ,  C07C211/17 ,  C07C211/27 ,  C07C227/06 ,  C07C229/14 ,  C07B31/00 ,  C09K3/00

CPC分类号： C07C29/143 ,  C07B2200/07 ,  C07B2200/09 ,  C07C29/14 ,  C07C209/52 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C211/17 ,  C07C211/27 ,  C07C211/45 ,  C07C211/52 ,  C07C31/12 ,  C07C31/125 ,  C07C35/08 ,  C07C35/20 ,  C07C33/46 ,  C07C33/22 ,  C07C33/24 ,  C07C33/18 ,  C07C33/20 ,  C07C35/21 ,  C07C35/18

摘要： A process of reducing unsaturated organic compounds efficiently by using industrially inexpensive and easily handleable trichlorosilane as the reducing agent to thereby obtain the corresponding reductants; and reducing agents. Specifically, a process for the preparation of reductants of unsaturated organic compounds, characterized by conducting the reduction of an unsaturated organic compound by mixing the compound with trichlorosilane in the presence of a compound capable of reacting with trichlorosilane to give a five-coordinate silicon complex, e.g., N-formylated secondary amine having 3 or more carbon atoms; and reducing agents consisting of specific silicon complexes.

摘要翻译： 减少不饱和有机化合物高效通过使用工业上廉价且容易处理能够三氯硅烷作为还原剂，从而获得相应的还原剂的方法; 和还原剂。 具体地，不饱和有机化合物，通过在化合物的存在下能够与三氯硅烷反应得到的五坐标硅复合物与三氯硅烷的化合物混合进行的不饱和有机化合物的还原为特征的还原剂的制备方法， 例如，N-甲酰化具有3个或更多个碳原子的仲胺; 和还原剂由......组成特定硅复合物。

公开(公告)号：EP1499574A2

公开(公告)日：2005-01-26

申请号：EP03751754.7

申请日：2003-04-29

申请人： McLaughlin, Hugh S.

发明人： McLaughlin, Hugh S.

IPC分类号： C07C33/18

CPC分类号： B01D53/0454 ,  B01D53/0438 ,  B01D53/72 ,  B01D53/73 ,  B01D2253/102 ,  B01D2257/70 ,  B01D2257/708 ,  B01D2259/40083 ,  B01J8/0278 ,  B01J8/0285 ,  B01J2208/00044 ,  B01J2208/00407 ,  B01J2208/00415

摘要： A method for oxidizing carbon adsorbable organic compounds in a controlled manner within a bed of activated carbon. The bed of activated carbon is exposed to a source of molecular oxygen, such as air, and is controlled within a temperature range whereby the molecular oxygen is slowly oxidizing the activated carbon. Under this controlled set of conditions, the activated carbon will oxidize organic compounds present within the bed of activated carbon. This technique has widespread versatility for the controlled destruction of organic vapors and liquids by activated carbon and applications for the regeneration of spent activated carbons containing previously adsorbed organic compounds.

公开(公告)号：EP0751927A4

公开(公告)日：1998-07-29

申请号：EP95917549

申请日：1995-03-23

申请人： CALIFORNIA INST OF TECHN

发明人： MYERS ANDREW G

IPC分类号： C07D521/00 ,  B01J31/02 ,  C07B53/00 ,  C07C29/00 ,  C07C29/147 ,  C07C31/10 ,  C07C31/125 ,  C07C33/18 ,  C07C33/34 ,  C07C45/41 ,  C07C45/45 ,  C07C45/67 ,  C07C47/02 ,  C07C47/228 ,  C07C49/04 ,  C07C49/213 ,  C07C49/76 ,  C07C49/782 ,  C07C51/06 ,  C07C53/126 ,  C07C57/30 ,  C07C227/18 ,  C07C227/32 ,  C07C231/12 ,  C07C231/18 ,  C07C233/17 ,  C07C233/18 ,  C07C233/22 ,  C07C235/02 ,  C07C235/34 ,  C07C237/06 ,  C07C237/16 ,  C07C271/22 ,  C07F7/18 ,  C07F9/50 ,  C07C229/00 ,  C07C53/00 ,  C07C53/132 ,  C07C227/14 ,  C07C231/16 ,  C07C233/03

CPC分类号： C07C29/147 ,  C07B2200/07 ,  C07C45/41 ,  C07C45/45 ,  C07C45/673 ,  C07C47/02 ,  C07C47/228 ,  C07C49/213 ,  C07C49/76 ,  C07C49/782 ,  C07C53/126 ,  C07C57/30 ,  C07C227/18 ,  C07C227/32 ,  C07C231/12 ,  C07C231/18 ,  C07C233/17 ,  C07C233/18 ,  C07C233/22 ,  C07C235/02 ,  C07C235/34 ,  C07C237/06 ,  C07C237/16 ,  C07C271/22 ,  C07C2603/18 ,  C07F7/1852 ,  C12C11/02 ,  C07C31/125 ,  C07C33/20

摘要： A method for synthesizing enantionmerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the α carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98 %, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.

公开(公告)号：EP0781749A3

公开(公告)日：1997-10-29

申请号：EP96309439.6

申请日：1996-12-23

申请人： Takasago International Corporation

发明人： Sakaguchi, Minzo, c/o Takasago Int. Co. ,  Imai, Takashi, c/o Takasago Int. Co. ,  Miura, Takashi, c/o Takasago Int. Co. ,  Yamazaki, Tetsuro, c/o Takasago Int. Co.

IPC分类号： C07C29/145 ,  C07C41/26 ,  C07C33/24 ,  C07C33/46 ,  C07C43/23 ,  C07C33/18

CPC分类号： C07C29/145 ,  C07C69/76 ,  C07C33/18 ,  C07C33/24 ,  C07C33/46

摘要： A process for producing a benzhydrol compound (II) which comprises hydrogenating a benzophenone compound (I) in the presence of a hydrogenation catalyst consisting of a transition metal complex, a base and an optically active diamine compound:
wherein R 1 to R 10 each represents H, OH, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkanoyl, etc., R 2 and R 3 , and R 8 and R 9 may form -CH=CH-CH=CH-, or any two of R 1 to R 9 adjacent to each other may be bonded to thereby form -OCH 2 O- or -(CH 2 ) 3 -. By using this process, optically active benzhydrol compounds which have a high purity and are useful as, for example, intermediates in the synthesis of drugs can be produced by simple procedures.

公开(公告)号：EP3906969A1

公开(公告)日：2021-11-10

申请号：EP20822935.1

申请日：2020-06-12

申请人： East China University of Science and Technology

发明人： LI, Honglin ,  ZHAO, Zhenjiang ,  WANG, Rui ,  SHEN, Yinchu ,  FU, Jianjun ,  XU, Yufang ,  QIAN, Xuhong ,  JIAO, Qian ,  LI, Shiliang

IPC分类号： A61P9/12 ,  A61K31/047 ,  C07C33/26 ,  C07C33/18 ,  C07C33/36 ,  C07C33/34 ,  C07D309/02

摘要： The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

公开(公告)号：EP3717455A1

公开(公告)日：2020-10-07

申请号：EP18816468.5

申请日：2018-11-30

申请人： Vertex Pharmaceuticals Incorporated

发明人： LEMERCIER LEWANDOWSKI, Berenice ,  LEWIS, Robert ,  LOOKER, Adam ,  MORGAN, Adam ,  ROEPER, Stefanie ,  RYAN, Michael ,  SOLSONA ROCABERT, Juan, Gabriel ,  WILDE, Nathan

IPC分类号： C07D215/56 ,  C07C69/96 ,  C07B59/00 ,  C07C33/18