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1.发明公开
公开(公告)号：EP4378925A1
公开(公告)日：2024-06-05
申请号：EP21951294.4
申请日：2021-07-29
发明人： YANG, Jinwei , YE, Chenghao , XIA, Gang , HUO, Pengchao , DING, Wen , CHEN, Longfei , JIAO, Lin , HUANG, Hao , HENG, Xin , ZHU, Jingjing , YING, Yuebin , LIANG, Xuejun
IPC分类号： C07C269/00 , C07C269/06 , C07C271/22 , C07C231/12 , C07C235/74 , C07D233/56 , C07D207/46 , C07C51/41 , C07C53/18 , C07C201/12 , C07C205/43 , C07C41/16 , C07C43/178 , C07K14/61 , A61K38/27 , A61K47/60 , A61K47/68 , A61P5/06 , A61P35/00
CPC分类号： A61K38/27 , A61K47/60 , A61K47/68 , A61P5/06 , A61P35/00 , C07C41/16 , C07C43/178 , C07C51/41 , C07C53/18 , C07C201/12 , C07C205/43 , C07C231/12 , C07C235/74 , C07C269/00 , C07C269/06 , C07C271/22 , C07D207/46 , C07D233/56 , C07K14/61
摘要： The invention provides an unnatural amino acid, which is a compound with a structure as shown in formula (I) or an enantiomer thereof. The invention further provides use of the unnatural amino acid. Furthermore, the invention further provides a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the invention is simple and convenient to prepare, safe in nature, not easy to be inactivated when being inserted into a protein, and has a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid provided by the invention is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate,
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公开(公告)号：EP4347560A1
公开(公告)日：2024-04-10
申请号：EP22732751.7
申请日：2022-05-24
发明人： SCHULTHEISS, Nate , HOUSTON, Travis Lee , PARENT, Stephan D. , SETIAWAN, Nico , MCCRACKEN, Lisa M. , JONAITIS, David
IPC分类号： C07D209/16 , C07D213/80 , C07C51/41 , C07C53/126 , C07C55/06 , C07C55/14 , C07C57/15 , C07C59/08 , C07C59/255 , C07C63/08 , A61P25/18 , A61K31/4045
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3.发明公开
公开(公告)号：EP4342900A1
公开(公告)日：2024-03-27
申请号：EP23806780.5
申请日：2023-05-10
发明人： YANG, Cheng , YANG, Guang , ZHOU, Honggang
IPC分类号： C07D493/10 , C07C57/15 , C07C51/41 , A61K31/365 , A61K39/395 , A61P35/00
摘要： The present invention relates to sesquiterpene derivatives represented by formula (I) or pharmaceutically acceptable salts thereof, a pharmaceutical composition comprising the sesquiterpene derivative and a PD-1 antibody as active components, and a preparation method therefor and the use thereof. The sesquiterpene derivatives or the pharmaceutically acceptable salts thereof of the present invention can remarkably enhance the response and treatment effects of a PD-1 antibody to tumors, and combined administration of the sesquiterpene derivatives or the pharmaceutically acceptable salts thereof and the PD-1 antibody presents an obvious synergistic effect and shows extremely strong anti-tumor activity. Therefore, the present invention provides a new way for clinical treatment of tumors and has potential clinical application value and great clinical application prospect.
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公开(公告)号：EP4103543B1
公开(公告)日：2023-12-06
申请号：EP21705448.5
申请日：2021-02-10
发明人： SØNDERGAARD, Kåre
IPC分类号： C07C231/02 , C07C231/16 , C07C51/487 , C07C51/41 , C07B53/00
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公开(公告)号：EP4244407A1
公开(公告)日：2023-09-20
申请号：EP21805541.6
申请日：2021-11-10
发明人： KLEMT, Andreas , SCHOLZ, Sven
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公开(公告)号：EP3983368B1
公开(公告)日：2023-08-02
申请号：EP20730676.2
申请日：2020-06-11
IPC分类号： C07C51/083 , C07C51/41 , C07C51/56 , C07C407/00 , C07C409/34 , C07C53/122 , C07C53/124 , C07C53/126 , C07C53/128
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公开(公告)号：EP4077261B1
公开(公告)日：2023-06-07
申请号：EP20825399.7
申请日：2020-12-04
IPC分类号： C07C51/41 , C07C227/16 , C07C229/76
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公开(公告)号：EP4169900A1
公开(公告)日：2023-04-26
申请号：EP22202907.6
申请日：2022-10-21
发明人： GOUGET, Valentin
摘要： La présente invention vise à titre principal un procédé de préparation d'un matériau de type carboxylate de métal alcalin électro-actif, comprenant au moins les étapes consistant à
(i) disposer d'un mélange solide comprenant au moins un composé source en ions alcalins et au moins un composé aromatique polycondensé choisi parmi les (poly)acides carboxyliques aromatiques polycondensés et les (poly)anhydrides d'acide aromatique polycondensé,
(ii) soumettre ledit mélange solide de l'étape (i) à une contrainte mécanique propice à l'interaction mécanochimique desdits composé(s) source en ions alcalins et composé(s) aromatique(s) polycondensé(s) pour former ledit carboxylate de métal alcalin, et
(iii) récupérer ledit matériau de type carboxylate de métal alcalin, notamment par tamisage.-
公开(公告)号：EP4169899A1
公开(公告)日：2023-04-26
申请号：EP21829604.4
申请日：2021-06-22
IPC分类号： C07C51/41 , A01N37/36 , A01N55/02 , A01P1/00 , A01P3/00 , A61K33/38 , A61P31/04 , A61P31/12 , C07C59/265 , C07F1/10
摘要： Provided are powder of a pure disilver hydrogen citrate-containing composition in powder form, having excellent solubility, and a method for easily obtaining the disilver hydrogen citrate-containing composition with high efficiency. In addition, provided are an antibacterial agent or antiviral agent, containing the disilver hydrogen citrate-containing composition, and a method for producing the same.
The method for producing a disilver hydrogen citrate-containing composition of the present invention includes the following processes (1) to (3):
(1) preparing a reaction mixture containing a silver compound and citric acid, the reaction mixture having a pH of 2.0 to 5.5;
(2) precipitating the disilver hydrogen citrate-containing composition from the reaction mixture; and
(3) collecting the precipitated disilver hydrogen citrate-containing composition.-
公开(公告)号：EP4103543A1
公开(公告)日：2022-12-21
申请号：EP21705448.5
申请日：2021-02-10
申请人： Cheminova A/S
发明人： SØNDERGAARD, Kåre
IPC分类号： C07C231/02 , C07C231/16 , C07C51/487 , C07C51/41 , C07B53/00
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