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    PROCESS FOR PRODUCING LIQUID METAL CHELATE COMPOUND AND METAL CHELATE COMPOUND
    5.
    发明公开
    PROCESS FOR PRODUCING LIQUID METAL CHELATE COMPOUND AND METAL CHELATE COMPOUND 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINERFLÜSSIGENMETALLCHELATVERBINDUNG UND METALLCHELATVERBINDUNG

    公开(公告)号：EP2298725A1

    公开(公告)日：2011-03-23

    申请号：EP09762357.3

    申请日：2009-05-21

    申请人： SUGIMOTO, Mikio

    发明人： SUGIMOTO, Mikio

    IPC分类号： C07C51/41 ,  C07C55/10 ,  C07C59/245 ,  C07C59/255 ,  C07C59/265 ,  C07C65/42 ,  C07C229/16

    CPC分类号： C07C51/00

    摘要： The present invention is intended to provide a method for producing a liquid metal chelate compound which may be used as it is or diluted in water or the like, in a very simple procedure, in a short time, in a large quantity, and at a low cost, and to provide a metal chelate compound.
    A metal is ground in a liquid containing an organic acid to form an unoxidized fine metal powder. For example, a metal is ground in a liquid containing the organic acid, or the organic acid is added after the metal is ground in a liquid, or the organic acid is added while grinding the metal in a liquid. The unoxidized fine metal powder is oxidized in the liquid containing an organic acid to generate a metal ion. As a result of this, the unoxidized fine metal powder is chemically bonded to the organic acid in the liquid thereby producing a liquid metal chelate compound. The liquid metal chelate compound is adsorbed by an absorber.

    摘要翻译： 本发明旨在提供一种液体金属螯合物的制备方法，该方法可以以非常简单的方法，在短时间内，大量和在 低成本，并提供金属螯合物。 将金属在含有机酸的液体中研磨以形成未氧化的细金属粉末。 例如，在含有有机酸的液体中研磨金属，或者在金属在液体中研磨后添加有机酸，或者在将金属粉碎成液体的同时加入有机酸。 未氧化的细金属粉末在含有机酸的液体中被氧化，生成金属离子。 结果，未氧化的细金属粉末与液体中的有机酸化学键合，从而生成液态金属螯合物。 液体金属螯合物被吸收剂吸附。

    Physiologically active substance tan-931, its derivatives, their production and use
    6.
    发明公开
    Physiologically active substance tan-931, its derivatives, their production and use 失效
    Physiologisch aktive Substanz tan-931，ihre Derivate，ihre Herstellung und Verwendung。

    公开(公告)号：EP0342665A2

    公开(公告)日：1989-11-23

    申请号：EP89108926.0

    申请日：1989-05-18

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Kanamaru, Tsuneo ,  Hida, Tsuneaki ,  Muroi,, Masayuki

    IPC分类号： C07C65/42 ,  A61K31/19 ,  A61K31/235 ,  C07D265/30

    CPC分类号： C07D295/192 ,  C07C65/40 ,  C07C65/42 ,  C07C235/84 ,  C07D313/12

    摘要： A novel compound of the formula (I):
    wherein R₁ is optionally esterified or amidated carboxyl; R₂, R₃ and R₄ are the same or different and are hydrogen or alkyl; A is fcrmyl, hydroxyiminomethyl or carboxyl; and X is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active component the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R₁ is carboxyl, R₂, R₃ and R₄ are hydrogen and X is formyl are also disclosed.

    摘要翻译： 式（I）的新型化合物：其中R 1任选被酯化或酰胺化的羧基; R2，R3和R4相同或不同，为氢或烷基; A是fcrmyl，羟基亚氨基甲基或羧基; 并且X是氢或卤素或其盐，其可用作芳香酶抑制剂或其生产的中间体。 制备式（I）化合物的方法和含有作为活性成分的式（I）化合物的芳香酶抑制剂的方法，其中A是甲酰基，X是氢，或其盐，以及能产生青霉素的青霉菌（Penicillium funiculosum） 还公开了其中R 1是羧基，R 2，R 3和R 4是氢并且X是甲酰基的化合物（I）。