METHOD FOR PRODUCING 1,2-PHENYLETHANE COMPOUND USING ATOM TRANSFER RADICAL COUPLING REACTION
    7.
    发明公开
    METHOD FOR PRODUCING 1,2-PHENYLETHANE COMPOUND USING ATOM TRANSFER RADICAL COUPLING REACTION 审中-公开
    VERFAHREN ZUR HERSTELLUNG EINER 1,2-PHENYLETHANVERBINDUNG MITTELS RADIKALISCHER ATOMTRANSFER-KOPPLUNGSREAKING

    公开(公告)号:EP1997798A1

    公开(公告)日:2008-12-03

    申请号:EP07738838.7

    申请日:2007-03-16

    发明人: NIITANI, Takeshi

    摘要: An object of the present invention is to provide a method capable of producing a 1,2-phenylethane compound with extremely high yield in a short amount of time. Disclosed is a method for producing a 1,2-phenylethane compound, which comprises subjecting a compound represented by formula (I):

    wherein Ra represents a hydrogen atom or a substituted or unsubstituted phenyl group; Rb represents a hydrogen atom or a substituent; n represents an integer of 1 to 5 and, when n is 2 or more, Rb may be the same or different, or may be combined with each other to form a ring; and X represents a halogen atom; to a coupling reaction in the presence of a transition metal complex to produce a compound represented by formula (II):

    摘要翻译: 本发明的目的是提供一种能够在短时间内以极高产率制备1,2-苯基乙烷化合物的方法。 公开了1,2-苯基乙烷化合物的制造方法,其包括使式(I)表示的化合物:其中,Ra表示氢原子或取代或未取代的苯基; Rb表示氢原子或取代基; n表示1〜5的整数,当n为2以上时,R b可以相同或不同,也可以相互结合形成环。 X表示卤原子; 在过渡金属络合物的存在下进行偶联反应,生成由式(II)表示的化合物: