-
公开(公告)号：EP4292594A3
公开(公告)日：2024-03-27
申请号：EP23201915.8
申请日：2016-11-01
IPC分类号： C07D401/14 , C07D403/14 , A61P35/00 , A61K31/53 , A61K31/506 , A61K31/4439 , C07D239/30 , C07D239/34 , C07D239/38 , C07D403/12
摘要： Inhibitors of wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
-
2.发明公开
公开(公告)号：EP4288418A1
公开(公告)日：2023-12-13
申请号：EP22703589.6
申请日：2022-01-28
发明人： MCLEOD, Michael Charles , BRAUN, Ralf , SCHNATTERER, Stefan , SCHMUTZLER, Dirk , REINGRUBER, Anna Maria , BOLLENBACH-WAHL, Birgit , DITTGEN, Jan , GATZWEILER, Elmar , PADMANABAN, Mohan , ROTH, Sina
IPC分类号： C07D239/38 , A01N43/54 , C07D213/643 , C07D239/34 , C07D241/18
-
公开(公告)号：EP3994125A1
公开(公告)日：2022-05-11
申请号：EP20746791.1
申请日：2020-07-01
发明人： VACCA, Joseph
IPC分类号： C07D213/82 , C07D239/36 , C07D239/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D491/052 , A61P1/16
-
公开(公告)号：EP3484854B1
公开(公告)日：2021-01-20
申请号：EP17830436.6
申请日：2017-07-17
发明人： ZHANG, Zhiyuan , WANG, Xiaodong , HUANG, Shaoqiang , JIANG, Xian , LI, Li , ZHANG, Zhaolan , HAN, Jianguang
IPC分类号： A61K31/505 , A61P25/00 , A61P25/16 , A61P25/28 , A61P37/00 , A61P9/10 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/506 , C07D401/04 , C07D401/10 , C07D403/04 , C07D239/38 , C07D239/47 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04
-
公开(公告)号：EP3205647B1
公开(公告)日：2020-05-13
申请号：EP16189468.8
申请日：2010-08-17
发明人： CHIOSIS, Gabriela , TALDONE, Tony , RODINA, Anna , PATEL, Pallav , KANG, Yanlong
IPC分类号： C07D239/60 , C07D239/38 , C07D239/56 , C07D239/47 , C07D495/04 , C07D403/12 , A61K31/496 , A61K31/506 , A61K31/513 , A61K31/54 , A61P35/00
-
公开(公告)号：EP3195867B1
公开(公告)日：2019-09-04
申请号：EP17158250.5
申请日：2012-02-27
申请人： Ustav organicke chemie a biochemie Akademie ved CR, v.v.i. , Ustav experimentalni mediciny Akademie ved CR, v.v.i.
发明人： Jansa, Petr , Holy, Antonin , Zidek, Zdenek , Kmonickova, Eva , Janeba, Zlatko
IPC分类号： A61K31/505 , A61K31/506 , C07D239/20 , C07D239/34 , C07D239/36 , C07D239/38 , C07D239/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , A61P29/00 , A61P35/00 , A61P37/00
-
公开(公告)号：EP3409666A2
公开(公告)日：2018-12-05
申请号：EP18168338.4
申请日：2013-06-05
发明人： WANG, Binghe , TAI, Phang-Cheng , JIN, Jinshan , HSIEH, Yinghsin , RITTER, Ying-Ju , CUI, Jianmei , CHAUDHARY, Arpana S , DAI, Chaofeng , DAMERA, Krishna , CHEN, Weixuan
IPC分类号： C07D401/14 , C07D311/58 , C07D311/82 , C07D311/86 , C07D403/14 , C07D239/38 , C07D417/14 , C07D249/12 , C07D471/10 , C07D491/20 , C07D495/04
CPC分类号： C07D311/86 , A61K31/496 , C07C63/331 , C07D239/20 , C07D239/22 , C07D239/38 , C07D239/56 , C07D239/60 , C07D249/12 , C07D311/58 , C07D311/74 , C07D311/82 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/10 , C07D491/20 , C07D493/10 , C07D495/04 , C07D497/04 , C09B11/24 , G01N33/6872 , G01N2333/4706 , Y02A50/473
摘要： Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.
-
8.发明公开
公开(公告)号：EP2951156A1
公开(公告)日：2015-12-09
申请号：EP13817650.8
申请日：2013-11-27
申请人： Grünenthal GmbH
IPC分类号： C07D213/81 , C07D213/82 , C07D241/24 , C07C323/63 , C07D277/56 , C07D237/24 , C07D239/38 , A61K31/426 , A61K31/4965 , A61K31/505 , A61P25/00
CPC分类号： C07D277/56 , A61K31/166 , A61K31/426 , A61K31/44 , A61K31/4436 , A61K31/4965 , A61K31/50 , A61K31/505 , C07C323/62 , C07D213/81 , C07D213/82 , C07D237/24 , C07D239/38 , C07D241/24 , C07D409/12 , C07D471/04 , C07D495/04
摘要： The invention relates to specific carboxamides of formula (I) as KCNQ2/3 modulators, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.
摘要翻译： 本发明涉及特定的甲酰胺，其制备方法，包含这些化合物的药物以及这些化合物在制备药物中的用途。
-
公开(公告)号：EP2712861B1
公开(公告)日：2015-07-29
申请号：EP13198843.8
申请日：2011-06-15
发明人： Ouk, Samedy , Gunic, Esmir , Vernier, Jean-Michel
IPC分类号： C07D213/70 , C07D401/04 , C07D241/18 , A61K31/44 , A61K31/444 , A61K31/4965 , A61P19/06 , A61P9/12 , A61P9/00 , C07D403/04 , C07D405/04 , C07D239/38 , C07D417/04
CPC分类号： C07D213/70 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/4965 , A61K31/497 , A61K31/502 , A61K31/505 , A61K31/506 , A61K31/519 , A61K45/06 , C07D239/38 , C07D241/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10
-
10.发明公开N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors 有权N-二Hydroxylsulfonamidderivate新的生理有用的硝酰基供体
公开(公告)号：EP2489350A1
公开(公告)日：2012-08-22
申请号：EP12155608.8
申请日：2007-03-16
发明人： Toscano, John, P. , Brookfield, Frederick, Arthur , Cohen, Andrew, D. , Courtney, Stephen, Martin , Frost, Lisa, Marie , Kalish, Vincent, Jacob
IPC分类号： A61K31/18 , A61P9/04 , C07D207/36 , C07D213/71 , C07D213/74 , C07D231/18 , C07D233/84 , C07D239/38 , C07D241/18 , C07D249/12 , C07D261/10 , C07D277/36 , C07D285/12 , C07D307/64 , C07D333/34
CPC分类号： C07C311/48 , C07C317/14 , C07C323/67 , C07D213/74 , C07D231/18 , C07D261/10 , C07D263/58 , C07D285/125 , C07D295/096 , C07D307/82 , C07D309/12 , C07D317/14 , C07D333/34 , C07D333/62
摘要： The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
-
-
-
-
-
-
-
-
-
搜索结果
343 条记录 (耗时 0.034 秒)
