公开(公告)号：EP2268635B1

公开(公告)日：2015-06-10

申请号：EP08874003.0

申请日：2008-11-03

申请人： Taigen Biotechnology Co., Ltd.

发明人： YEN, Chi-Feng ,  HU, Cheng-Kung ,  HUANG, Chang-Pin ,  HUANG, Ying-Huey ,  HAKIMELAHI, Gholam Hossein ,  KING, Chi-Hsin Richard

IPC分类号： C07D239/50 ,  C07D251/54 ,  C07D403/04 ,  A61P29/00 ,  A61P35/00

CPC分类号： C07D239/50 ,  C07D251/54 ,  C07D403/04

公开(公告)号：EP2805947A4

公开(公告)日：2015-05-27

申请号：EP13738361

申请日：2013-01-15

申请人： INST PHARM & TOXICOLOGY AMMS ,  UNIV BEIJING

发明人： LI SONG ,  WANG YING ,  XIAO JUNHAI ,  MA DALONG ,  GONG HONGWEI ,  QI HUI ,  WANG LILI ,  LING XIAOMEI ,  ZHENG ZHIBING ,  ZHANG YANG ,  ZHONG WU ,  LI MEINA ,  XIE YUNDE ,  XU ENQUAN ,  LI XINGZHOU ,  MA JING ,  ZHAO GUOMING ,  ZHOU XINBO ,  WANG XIAOKUI ,  LIU HONGYING

IPC分类号： C07D403/14 ,  A61K31/506 ,  A61K31/519 ,  A61P11/06 ,  A61P17/00 ,  A61P29/00 ,  A61P37/00 ,  C07D239/50 ,  C07D403/12 ,  C07D417/12

CPC分类号： C07D471/04 ,  C07D239/50 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D417/12

公开(公告)号：EP2440533A4

公开(公告)日：2013-03-27

申请号：EP10785625

申请日：2010-06-14

申请人： SOCPRA SCIENCES ET GENIE SEC

发明人： MULHBACHER JEROME ,  LAFONTAINE DANIEL ,  MALOUIN FRANCOIS ,  ALLARD MARIANNE ,  MARSAULT ERIC

IPC分类号： C07D239/46 ,  A61K31/513 ,  A61K31/519 ,  A61L2/16 ,  A61P31/04 ,  C07D239/48 ,  C07D239/50 ,  C07D239/56 ,  C07D498/04 ,  C07D513/04 ,  G01N33/569

CPC分类号： A61K31/675 ,  A61K31/4412 ,  A61K31/505 ,  A61K31/513 ,  A61K31/519 ,  A61K31/535 ,  A61K31/5383 ,  A61K31/54 ,  A61K31/542 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D498/04 ,  C07D513/04 ,  Y10T436/141111 ,  Y10T436/143333

摘要： The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.

公开(公告)号：EP2388249A1

公开(公告)日：2011-11-23

申请号：EP11177764.5

申请日：2006-01-27

申请人： Tibotec Pharmaceuticals

发明人： Heeres, Jan ,  Lewi, Paulus Joannes ,  Janssen, Paul Adriaan Jan ,  Leemans, Rudolf ,  Moens, Luc Jozef Raphael

IPC分类号： C07D239/50 ,  C07D239/48 ,  A61K31/505 ,  A61P31/18

CPC分类号： C07D239/50 ,  C07D239/48

摘要： HIV replication inhibitors of formula

pharmaceutically acceptable addition salts or stereochemically isomeric forms thereof, wherein X is S, SO or SO 2 ; the preparation of these compounds as well as pharmaceutical compositions comprising these compounds; the use of these compounds for the prevention or the treatment of HIV infection.

摘要翻译： 其药学上可接受的加成盐或立体化学异构形式的HIV复制抑制剂，其中X是S，SO或SO 2; 这些化合物的制备以及包含这些化合物的药物组合物; 使用这些化合物来预防或治疗艾滋病毒感染。

公开(公告)号：EP2210879A1

公开(公告)日：2010-07-28

申请号：EP08022523.8

申请日：2008-12-30

申请人： Bayer CropScience AG

发明人： Minn, Klemens ,  Dietrich, Hansjörg ,  Dittgen, Jan ,  Feucht, Dieter ,  Häuser-Hahn, Isolde ,  Rosinger, Chris

IPC分类号： C07D239/48 ,  C07D239/50 ,  C07D405/12 ,  A01N43/54

CPC分类号： C07D239/48 ,  A01N43/54 ,  C07D239/50 ,  C07D405/12

摘要： Beschrieben werden Verbindungen der allgemeinen Formel (I) und deren agrochmisch-verträglichen Salze

und deren Verwendung im Bereich des Pflanzenschutzes.

摘要翻译： 描述了通式（I）化合物及其它们的agrochmisch上可接受的盐以及它们在植物保护领域中使用的化合物。

公开(公告)号：EP2140864A3

公开(公告)日：2010-01-27

申请号：EP09010003.3

申请日：2002-01-31

申请人： H. Lundbeck A/S

发明人： Blackburn, Thomas P. ,  Konkel, Michael ,  Boteju, Lakmal W. ,  Talisman, Ian Jamie ,  Wetzel, John M. ,  Packiarajan, Mathivanaan ,  Chen, Heidi ,  Jimenez, Hermo ,  Lagu, Bharat ,  Lim, Kitae ,  Noble, Stewart

IPC分类号： A61K31/407 ,  A61K31/506 ,  C07D209/40 ,  C07D239/50 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D417/12 ,  A61P25/24

CPC分类号： A61K31/407 ,  A61K31/00 ,  A61K31/506 ,  C07D209/40 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D417/12

摘要： This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety. This invention also provides a method of treating depression and/or anxiety in a subject which comprises administering to the subject a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a GAL3 receptor antagonist.

公开(公告)号：EP1937653A1

公开(公告)日：2008-07-02

申请号：EP06846967.5

申请日：2006-09-07

申请人： H.Lundbeck A/S

发明人： KHANZHIN, Nikolay ,  GREVE, Daniel, Rodriguez ,  ROTTLÄNDER, Mario

IPC分类号： C07D239/50 ,  C07D239/48 ,  A61K31/505 ,  A61K31/5377 ,  A61P25/08

CPC分类号： C07D239/50 ,  C07D239/48

摘要： The present invention relates to pyrimidine derivatives of the general formula I or salts thereof and their use as openers of the KNCQ family potassium ion channels, particularly in the treatment of epilepsy.

公开(公告)号：EP0727213B9

公开(公告)日：2007-11-07

申请号：EP95120378.5

申请日：1989-12-06

申请人： THE WELLCOME FOUNDATION LIMITED

发明人： Miller, Alistair Ainslie ,  Nobbs, Malcolm Stuart ,  Hyde, Richard Martin ,  Leach, Michael John

IPC分类号： A61K31/505 ,  A61K31/535 ,  C07D239/48 ,  C07D239/50 ,  C07D239/60 ,  C07D239/42 ,  C07D239/46

CPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  A61K31/535 ,  A61K31/5355 ,  A61K31/5377 ,  C07C255/54 ,  C07C255/56 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/56 ,  C07D239/58

公开(公告)号：EP1771452A2

公开(公告)日：2007-04-11

申请号：EP05775512.6

申请日：2005-07-26

申请人： BIOCRYST PHARMACEUTICALS, INC.

发明人： BABU, Yarlagadda S. ,  KAMATH, Vivekanand P. ,  MORRIS, JR., Philip E.

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07D207/12 ,  C07D207/22 ,  C07D239/32 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  A61K31/4015 ,  A61K31/506 ,  A61K31/4025

CPC分类号： C07D487/04

摘要： Described are compounds of the general formula (I), VI and (VII). Also described are pharmaceutical compositions comprising the compounds identified. The compounds and pharmaceutical compositions described are inhibitors of 5'-methylthioadenosine/S-adenosylhomocystein nucleosidase (MTAN) and/or 5'-methylthioadenosine phosphorylase (MTAP). Methods of treatment using the compounds and pharmaceutical compositions described are also provided for preventing and/or treating disease states and/or conditions by inhibiting MTAN and/or MTAP in patients.

公开(公告)号：EP1507775A4

公开(公告)日：2006-05-24

申请号：EP03731419

申请日：2003-05-27

申请人： ELAN PHARM INC

发明人： KONRADI ANDREI W ,  SEMKO CHRISTOPHER M ,  XU YING-ZI ,  STAPPENBECK FRANK ,  STUPI BRIAN P ,  SMITH JENIFER ,  THORSETT EUGENE D ,  PLEISS MICHAEL A

IPC分类号： C07D239/69 ,  C07D401/10 ,  A61K31/505 ,  A61K31/506 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D239/50 ,  C07D401/12 ,  C07D403/12

CPC分类号： C07D401/12 ,  C07D239/50 ,  C07D403/12