公开(公告)号：EP4241767B1

公开(公告)日：2024-10-23

申请号：EP23175192.6

申请日：2009-11-10

发明人： MANOHARAN, Muthiah ,  JAYARAMAN, Muthusamy ,  RAJEEV, Kallanthottathil, G. ,  ELTEPU, Laxman ,  ANSELL, Steven ,  CHEN, Jianxin

IPC分类号： A61K47/00 ,  A61K31/01 ,  C07D319/06 ,  C07D405/12 ,  C07D491/056 ,  C07D491/113 ,  C07D203/10 ,  C07D317/28 ,  A61K9/127 ,  A61K31/7088 ,  A61K39/00 ,  A61K31/713 ,  A61P35/00 ,  A61P37/04 ,  C07D317/46 ,  C07D317/72 ,  A61P33/00 ,  C07D317/44 ,  C12N15/11

公开(公告)号：EP4426685A1

公开(公告)日：2024-09-11

申请号：EP22890847.1

申请日：2022-11-04

申请人： Terran Biosciences Inc.

发明人： DUNCTON, Matthew ,  CLARK, Samuel ,  HENDERSON, Alistair ,  GOLDING, Bernard ,  MONERRIS MASCARO, Manuel ,  JOHNSON, Lucia ,  MADRID, Annette

IPC分类号： C07D317/46 ,  C07D317/58 ,  A61K31/36 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/32

CPC分类号： A61P25/22 ,  C07D317/54 ,  A61K45/06

公开(公告)号：EP4241767A3

公开(公告)日：2023-11-01

申请号：EP23175192.6

申请日：2009-11-10

申请人： Arbutus Biopharma Corporation

发明人： MANOHARAN, Muthiah ,  JAYARAMAN, Muthusamy ,  RAJEEV, Kallanthottathil, G. ,  ELTEPU, Laxman ,  ANSELL, Steven ,  CHEN, Jianxin

IPC分类号： A61K47/00 ,  A61K31/01 ,  C07D319/06 ,  C07D405/12 ,  C07D491/056 ,  C07D491/113 ,  C07D203/10 ,  C07D317/28 ,  A61K9/127 ,  A61K31/7088 ,  A61K39/00 ,  A61K31/713 ,  A61P35/00 ,  A61P37/04 ,  C07D317/46 ,  C07D317/72 ,  A61P33/00 ,  C07D317/44 ,  C12N15/11

摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells.

公开(公告)号：EP4242198A1

公开(公告)日：2023-09-13

申请号：EP22160490.3

申请日：2022-03-07

申请人： BASF SE

发明人： DEY, Chandan ,  DAS, Saikat ,  DIETZ, Jochen ,  LUDWIG, Lydia ,  KHANNA, Smriti ,  FEHR, Marcus ,  KOCH, Andreas ,  SIEPE, Isabella ,  LE VEZOUET, Ronan ,  CRAIG, Ian Robert ,  RATH, Rakesh ,  TEGGE, Vanessa ,  GRAMMENOS, Wassilios

IPC分类号： C07C251/60 ,  C07D317/46 ,  A01N43/30 ,  A01N43/40 ,  A01N37/44 ,  C07D213/65

摘要： The present invention relates to the use of strobilurin type compounds of formula I and the N-oxides and the salts thereof for combating phytopathogenic fungi containing an amino acid substitution F129L in the mitochondrial cytochrome b protein (also referred to as F129L mutation in the mitochondrial cytochrome b gene) conferring resistance to Qo inhibitors, and to methods for combating such fungi. The invention also relates to novel compounds, processes for preparing these compounds, to compositions comprising at least one such compound, and to seeds coated with at least one such compound.

公开(公告)号：EP4126836A1

公开(公告)日：2023-02-08

申请号：EP21722328.8

申请日：2021-04-02

申请人： Stealth BioTherapeutics Inc.

发明人： KEEFE, Dennis ,  ZHENG, Guozhu

IPC分类号： C07D319/18 ,  C07D317/46 ,  A61P9/00 ,  A61P27/02 ,  C07C39/08 ,  C07C43/23 ,  C07C50/06 ,  C07C50/24 ,  A61K31/122

公开(公告)号：EP3860985A1

公开(公告)日：2021-08-11

申请号：EP19868840.0

申请日：2019-10-04

申请人： SRF LIMITED

发明人： KUMARASAMY, Radha ,  RAVICHANDRAN, Poornachandran ,  RAJARAM, Aiyswariya ,  SEETHARAMAN, Prasannakumar ,  NAGAPPAN, Arumugam ,  KUMAR, Kapil ,  JAIN, Anurag

IPC分类号： C07D317/46

公开(公告)号：EP3699172A2

公开(公告)日：2020-08-26

申请号：EP20150151.7

申请日：2009-11-10

申请人： Arbutus Biopharma Corporation

发明人： Manoharan, Muthiah ,  Rajeev, Kallanthottathil, G. ,  Jayaraman, Muthusamy ,  Butler, David ,  Narayanannair, Jayaprakash, K. ,  Maier, Martin ,  Eltepu, Laxman

IPC分类号： C07D203/10 ,  C07D317/28 ,  C07D317/44 ,  C07D317/72 ,  C07D405/12 ,  C07D319/06 ,  C07D491/056 ,  C07D491/113 ,  C07D317/46 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/00 ,  A61P33/00 ,  A61P35/00 ,  A61P37/04 ,  C12N15/11

摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R 1 and R 2 are each independently for each occurrence optionally substituted C 10 -C 30 alkyl, optionally substituted C 10 -C 30 alkenyl, optionally substituted C 10 -C 30 alkynyl, optionally substituted C 10 -C 30 acyl, or -linker-ligand; R 3 is H, optionally substituted C 1 -C 10 alkyl, optionally substituted C 2 -C 10 alkenyl, optionally substituted C 2 -C 10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O=N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.

公开(公告)号：EP3697758A1

公开(公告)日：2020-08-26

申请号：EP18796291.5

申请日：2018-10-12

申请人： Novartis Inflammasome Research, Inc.

发明人： VENKATRAMAN, Shankar ,  GHOSH, Shomir ,  ROUSH, William R. ,  SHEN, Dong-Ming ,  KATZ, Jason ,  SEIDEL, Hans Martin

IPC分类号： C07D209/04 ,  C07D231/12 ,  C07D317/46 ,  C07C311/51 ,  A61P1/16 ,  A61P3/04 ,  A61P3/10 ,  A61P11/06 ,  A61P17/06 ,  A61P19/00 ,  A61P25/00 ,  A61P27/02 ,  A61P35/00 ,  A61K31/415 ,  A61K31/355 ,  A61K31/404

公开(公告)号：EP2785178A4

公开(公告)日：2015-09-30

申请号：EP12852566

申请日：2012-11-29

申请人： BIKAM PHARMACEUTICALS INC

发明人： QUACH TAN ,  BERMAN JUDD ,  GARVEY DAVID S

IPC分类号： C07C255/54 ,  A61K31/137 ,  A61P27/02 ,  C07C33/50 ,  C07C43/215 ,  C07C43/225 ,  C07C211/45 ,  C07C211/52 ,  C07C217/84 ,  C07C237/30 ,  C07C255/58 ,  C07C323/09 ,  C07D317/46 ,  C07D317/64 ,  C07D317/66

CPC分类号： C07C211/52 ,  C07C33/50 ,  C07C43/215 ,  C07C43/225 ,  C07C49/237 ,  C07C49/813 ,  C07C211/45 ,  C07C211/46 ,  C07C217/84 ,  C07C237/30 ,  C07C255/54 ,  C07C255/58 ,  C07C255/59 ,  C07C323/09 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07D317/46 ,  C07D317/64 ,  C07D317/66

摘要： Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

公开(公告)号：EP2810941A4

公开(公告)日：2015-07-29

申请号：EP12867588

申请日：2012-12-27

申请人： UNIV YONSEI IACF

发明人： PARK TAE SUN ,  JEONG NAK SHIN

IPC分类号： C07D317/46 ,  A61K31/36 ,  A61P3/00 ,  C07D405/12

CPC分类号： C07D405/12 ,  C07D211/06 ,  C07D295/192 ,  C07D317/58 ,  C07D317/60 ,  C07D317/62