公开(公告)号：EP4377321A1

公开(公告)日：2024-06-05

申请号：EP22753775.0

申请日：2022-07-21

申请人： University of KwaZulu-Natal ,  University of Zululand

发明人： GOVENDER, Thavendran ,  NAICKER, Tricia ,  ARVIDSSON, Per, I ,  KRUGER, Hendrik, G ,  PETERS, Byron

IPC分类号： C07D499/56 ,  C07D501/22 ,  C07D501/34 ,  C07D501/59 ,  A61P31/04 ,  A61K31/43 ,  A61K31/546

CPC分类号： C07D501/22 ,  C07D501/34 ,  C07D499/56 ,  C07D501/59 ,  A61P31/04 ,  Y02A50/30

公开(公告)号：EP2385054B1

公开(公告)日：2013-10-02

申请号：EP09836052.2

申请日：2009-12-29

申请人： Zhejiang Adamerck Biopharmlabs Inc.

发明人： QI, Youmao ,  YE, Fengqi ,  JIE, Qing ,  QI, Yingbei ,  ZHANG, Fengmin ,  YU, Baochun ,  YE, Tianjian ,  YU, Meiping

IPC分类号： C07D501/22 ,  A61K31/546 ,  A61P31/04

CPC分类号： C07D501/22 ,  A61K31/546

公开(公告)号：EP1809638B1

公开(公告)日：2010-02-17

申请号：EP04806740.9

申请日：2004-11-01

申请人： Hetero Drugs Limited

发明人： PARTHASARADHI REDDY, Bandi ,  RATHNAKAR REDDY, K., Hetero Drugs Limited (R & D) ,  RAJI REDDY, R., Hetero Drugs Limited (R & D) ,  MURALIDHARA REDDY, D., Hetero Drugs Limited R & D ,  MURALI, Nagabelli, Hetero Drugs Limited

IPC分类号： C07D501/04 ,  C07D501/22

CPC分类号： C07D501/22 ,  C07F7/188

摘要： The present invention relates to a process for preparing a key intermediate of cefprozil and use of this intermediate in the preparation of cefprozil thereby avoiding impurity-causing self-acylation. [R-(Z)]-[4-hydroxy-α-[(3-methoxy-l-methyl-3-oxo-1-propenyl)amino]] benzeneacetic acid, mono potassium salt is reacted with ethyl chloroformate to obtain mixed anhydride which is then silylated with N,O-bis(trimethylsilyl)acetamide. The silylated compound obtained is reacted with [7-trimethylsilylamino-3-(Z/E-propen-1-yl)-3-cephem-4-carboxylic acid]trimethylsilyl ester and deprotected with aqueous hydrochloric acid to give cefprozil.

公开(公告)号：EP1379530A4

公开(公告)日：2008-04-02

申请号：EP02720650

申请日：2002-04-17

申请人： HANMI PHARM IND CO LTD

发明人： LEE GWAN SUN ,  CHANG YOUNG KIL ,  KIM HONG SUN ,  LEE JAE HEON ,  PARK CHUL HYUN ,  PARK GHA SEUNG ,  KIM CHEOL KYUNG

IPC分类号： C07D501/22 ,  A61K31/545 ,  A61P31/04 ,  C07D501/00 ,  C07D501/04

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephemcompound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; R1 is hydrogen or R2CH2CO-; and R2 is ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxy.

公开(公告)号：EP1273587A4

公开(公告)日：2007-12-26

申请号：EP01919924

申请日：2001-04-13

申请人： OTSUKA KAGAKU KK

发明人： KAMEYAMA YUTAKA ,  FUKAE KAZUHIRO

IPC分类号： A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/04 ,  C07D501/22

CPC分类号： C07D501/00

摘要： A process for the preparation of a 3-vinylcephem compound, characterized by treating a protected 3-vinylcephem derivative of the general formula (1) in an organic solvent in the presence of a perhalogenic acid and an organic protonic acid to thereby obtain a 3-vinylcephem compound of formula (2). In general formula (1), R?1, R2 and R3¿ are each hydrogen or optionally substituted arylmethyl, with the proviso that all of R?1, R2 and R3¿ must not be hydrogen.

公开(公告)号：EP1178043B1

公开(公告)日：2005-12-28

申请号：EP01912242.3

申请日：2001-03-09

申请人： TOKUYAMA CORPORATION

发明人： HIRANO, Naoki c/o Tokuyama Corporation ,  SAIJYO, Masako c/o Tokuyama Corporation

IPC分类号： C07D251/46 ,  C07D501/22 ,  C07D501/59 ,  C07D501/24 ,  C07D501/36 ,  C07D501/48 ,  C07C67/08 ,  C07C69/612 ,  C07C69/618 ,  C07C69/24 ,  C07C231/02

CPC分类号： C07D277/587 ,  C07C67/08 ,  C07C231/12 ,  C07C269/06 ,  C07D251/46 ,  C07D501/04 ,  C07D501/20 ,  C07D501/44 ,  C07D501/56 ,  C07D501/59 ,  C07C69/92 ,  C07C69/24 ,  C07C69/82 ,  C07C69/618 ,  C07C69/612

摘要： A method of improving the stability of a quaternary ammonium salt; and a process for efficiently producing the quaternary ammonium salt having improved stability.

公开(公告)号：EP1392703A4

公开(公告)日：2004-10-27

申请号：EP02730990

申请日：2002-06-05

申请人： HANMI PHARM IND CO LTD

发明人： LEE GWAN SUN ,  CHANG YOUNG KIL ,  KIM HONG SUN ,  PARK CHUL HUYN ,  PARK GHA SEUNG ,  KIM CHEOL KYUNG

IPC分类号： C07B61/00 ,  C07D501/00 ,  C07D501/14 ,  C07D501/22

CPC分类号： C07D501/00

摘要： High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdinir and reacting the crystalline salt with a base in a solvent.

摘要翻译： 通过包括以下步骤的方法以高收率制备高纯度头孢地尼：用甲酸 - 硫酸混合物或甲酸 - 甲磺酸混合物处理头孢地尼中间体以获得头孢地尼的结晶盐，并使该结晶盐与 在溶剂中的碱。

公开(公告)号：EP0597429B1

公开(公告)日：2003-02-26

申请号：EP93118094.7

申请日：1993-11-08

申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

发明人： Wieser, Josef

IPC分类号： C07D501/18 ,  C07D501/22 ,  C07D501/24

CPC分类号： C07D501/00

公开(公告)号：EP1132391A4

公开(公告)日：2002-06-12

申请号：EP00956989

申请日：2000-09-07

申请人： OTSUKA KAGAKU KK

发明人： KAMEYAMA YUTAKA

IPC分类号： A61P31/04 ,  C07D501/00 ,  C07D501/04 ,  C07D501/22 ,  C07D501/59

CPC分类号： C07D501/00

摘要： A process for the preparation of 3-sulfonyloxy-3-cephem compounds of general formula (3), characterized by reacting a 3-hydroxy-3-cephem compound of general formula (1) with a sulfonic acid halide of general formula (2) :R4SO2x, in an organic solvent in the presence of an alkali metal carbonate or an alkaline earth metal carbonate wherein R1 to R4 and X are each as defined in the description.

公开(公告)号：EP0592677B1

公开(公告)日：2001-11-07

申请号：EP93903302.3

申请日：1993-02-03

申请人： OTSUKA KAGAKU KABUSHIKI KAISHA

发明人： TORII, Shigeru 4-18, Sanyodanchi 4-chome ,  TANAKA, Hideo 5115-34, Haga ,  SASAOKA, Mitio 1-16, Nakanokoshi ,  SHIROI, Takashi 51-41, Aza Nishinosu Tainohama ,  KAMEYAMA, Yutaka 24-19-406, Okudahonmachi

IPC分类号： C07D205/08 ,  C07D501/00 ,  C07D501/18 ,  C07D501/22 ,  C07D501/57 ,  C07D501/60 ,  C07D205/09 ,  C07D205/095

CPC分类号： C07D205/09 ,  C07D205/095 ,  C07D501/00 ,  Y02P20/55