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公开(公告)号:EP4436555A2
公开(公告)日:2024-10-02
申请号:EP23743644.9
申请日:2023-01-17
申请人: Exocure Sweden AB
发明人: LÖTVALL, Jan , PARK, Kyong-su , LASSER, Cecilia
IPC分类号: A61K9/50 , A61K47/69 , C12N5/0784
CPC分类号: C07K14/705 , C12N5/0662 , C12N2510/0020130101 , A61K35/28 , A61K35/545 , A61K35/30 , A61K35/34 , A61K35/36 , A61P29/00 , A61K2035/12420130101
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公开(公告)号:EP4426817A2
公开(公告)日:2024-09-11
申请号:EP22891079.0
申请日:2022-11-04
IPC分类号: C12N5/0784 , A61K35/15 , A61K35/17 , A61K39/00 , A61P35/00 , C12N15/86 , C12N15/867
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3.
公开(公告)号:EP4332226A3
公开(公告)日:2024-05-08
申请号:EP24150956.1
申请日:2017-11-07
申请人: Genovie AB
发明人: JARVIS, Reagan , HILL, Ryan , PASE, Luke
IPC分类号: C07K14/725 , C12N5/0783 , C12N15/85 , C12N5/0784 , C12N15/63
CPC分类号: C07K14/7051 , C12N15/1093 , A61K2039/515420130101 , A61K2039/515620130101 , C12N5/0636 , A61K35/15
摘要: The present invention relates to a two-part device, wherein a first part is an engineered antigen-presenting cell system (eAPCS), and a second part is an engineered TCR-presenting cell system (eTPCS).
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公开(公告)号:EP4346912A1
公开(公告)日:2024-04-10
申请号:EP22730822.8
申请日:2022-05-25
IPC分类号: A61K48/00 , C07K14/47 , C07K14/725 , C12N5/0784 , A61K35/17 , A61K39/00 , C12N15/10 , C12N15/86
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公开(公告)号:EP4346852A1
公开(公告)日:2024-04-10
申请号:EP22816684.9
申请日:2022-05-27
申请人: Avotres, Inc.
发明人: JIANG, Hong
IPC分类号: A61K35/17 , C12N5/0784
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公开(公告)号:EP4308692A1
公开(公告)日:2024-01-24
申请号:EP22712426.0
申请日:2022-03-16
申请人: Technische Universität Dresden , Centre National de la Recherche Scientifique (CNRS) , Université d'Aix-Marseille , INSERM (Institut National de la Santé et de la Recherche Médicale)
IPC分类号: C12N5/0786 , C12N5/0784 , A61K35/15
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公开(公告)号:EP4279596A1
公开(公告)日:2023-11-22
申请号:EP21919587.2
申请日:2021-11-30
发明人: KASUYA, Hideki , NAOE, Yoshinori , MATSUMURA, Shigeru , EISSA, Ibrahim Ragab Nassr , ALI MOHAMED, Mohamed Abdelmoneim Ahmed
IPC分类号: C12N15/62 , A61K35/12 , A61K35/15 , A61K39/395 , A61P31/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/32 , C07K19/00 , C12N5/0784 , C12N5/0786 , C12N5/10 , C12N15/12 , C12N15/13
摘要: Provided is a chimeric target factor receptor capable of activating an antigen-presenting cell such as a dendritic cell in a target-factor-specific manner. The chimeric target factor receptor contains a target factor-binding domain, a transmembrane domain, and an intracellular domain containing a TLR intracellular domain.
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公开(公告)号:EP4219690A2
公开(公告)日:2023-08-02
申请号:EP23156772.8
申请日:2016-03-11
申请人: SYZ Cell Therapy Co.
发明人: ZHOU, Xiangjun , LI, Jin , HAN, Yanyan , WU, Dongyun , LIU, Junyun , TAO, Ran , TANG, Longqing
IPC分类号: C12N5/0783 , C12N5/0784 , C12N5/0786 , A61K38/17 , A61P35/00
摘要: Provided is a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Also provided are precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual, methods of preparing the activated T cells, methods of monitoring the treatment, methods of cloning tumor-specific T cell receptors, an isolated population of cells comprising the activated T cells, and compositions and kits useful for cancer immunotherapy.
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公开(公告)号:EP4196135A1
公开(公告)日:2023-06-21
申请号:EP21856741.0
申请日:2021-08-12
申请人: BioNTech US Inc.
发明人: JUNEJA, Vikram , DIETZE, Jared , CONN, Brandon , CHOI, Jaewon
IPC分类号: A61K35/17 , C12N5/0783 , A61K39/395 , C07K16/28 , C12N5/0784 , A01N1/02
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10.
公开(公告)号:EP4190894A1
公开(公告)日:2023-06-07
申请号:EP21212360.8
申请日:2021-12-03
申请人: CiMaas B.V.
IPC分类号: C12N5/0784
摘要: The invention is in the field of cell biology and immunology. The invention provides methods for the production of a vaccine for cancer and infectious diseases. More in particular it provides a method for the improved production of mature dendritic cells. This improved production includes the use of a bacterial lysate produced by a new method.
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