公开(公告)号：EP4134427A1

公开(公告)日：2023-02-15

申请号：EP22194754.2

申请日：2017-04-30

申请人： Biolegend, Inc.

发明人： GOHEL, Dhanesh ,  ZHANG, Hong ,  RANSOM, John

IPC分类号： C12N1/08 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/552

摘要： The present invention relates to a method of separating at least one target biomolecule species from a biological sample, comprising: (a) in a reaction mixture, contacting a biological sample known or suspected to contain first and second biomolecule species of interest with a targeted magnetic particle species, that targets the first biomolecule species of interest to form first target biomolecule/magnetic particle complexes and a targeted buoyant particle species, that targets the second biomolecule species of interest to form second target biomolecule/buoyant particle complexes; (b) isolating the first biomolecule/magnetic particle complexes from the reaction mixture using a magnetic field; and (c) separating the second target biomolecule/buoyant particle complexes from the reaction mixture using buoyancy/flotation properties.

公开(公告)号：EP3448981B1

公开(公告)日：2022-12-07

申请号：EP17790625.2

申请日：2017-04-30

发明人： GOHEL, Dhanesh ,  ZHANG, Hong ,  RANSOM, John

IPC分类号： C12N1/08 ,  C12Q1/68 ,  G01N33/543 ,  G01N33/552

公开(公告)号：EP3646009A1

公开(公告)日：2020-05-06

申请号：EP18825104.5

申请日：2018-06-25

申请人： Becton, Dickinson and Company

发明人： YANG, Jian ,  REN, Huimiao

IPC分类号： G01N21/64 ,  G01N33/543 ,  G01N33/552

公开(公告)号：EP3035057B1

公开(公告)日：2018-11-14

申请号：EP14836946.5

申请日：2014-08-08

申请人： Furukawa Electric Co. Ltd.

发明人： NISHIDA, Masataka ,  YAMANAKA, Nobumitsu ,  MIYOSHI, Kazutomi ,  OHKUBO, Michio

IPC分类号： G01N33/58 ,  G01N33/552 ,  C09K11/06 ,  G01N33/543

CPC分类号： G01N33/552 ,  G01N33/54353 ,  G01N33/582

摘要： Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm 2 ; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.

公开(公告)号：EP2170776B1

公开(公告)日：2018-11-07

申请号：EP08779740.3

申请日：2008-06-24

申请人： Prime Synthesis, Inc.

发明人： ROTHSTEIN, Marc, L. ,  ROTHSTIEN, Dianne, M. ,  LEE, Dan, P.

IPC分类号： C03C11/00 ,  C03C17/32 ,  C07H21/00 ,  C08F8/30 ,  C08F8/32 ,  C09D125/18 ,  G01N33/543 ,  G01N33/552

CPC分类号： C07H21/00 ,  C03C11/00 ,  C03C17/32 ,  C03C17/328 ,  G01N33/54313 ,  G01N33/54353 ,  G01N33/552 ,  Y10T428/2989 ,  Y10T428/2996 ,  Y10T428/2998

摘要： A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.

公开(公告)号：EP3383823A1

公开(公告)日：2018-10-10

申请号：EP16802101.2

申请日：2016-11-30

申请人： Universiteit Antwerpen

发明人： BLUST, Ronny ,  LENAERTS, Silvia ,  TYTGAT, Tom ,  VAN EYNDE, Erik

IPC分类号： C04B35/14 ,  C04B35/634 ,  C04B35/638 ,  C04B38/00 ,  C09D7/12 ,  G01N33/552

CPC分类号： C04B35/14 ,  C04B35/63468 ,  C04B35/638 ,  C04B38/009 ,  C04B2111/00793 ,  C04B2111/00801 ,  C04B2111/0081 ,  C04B2111/00827 ,  C04B2111/00836 ,  C04B2235/3232 ,  C04B2235/3418 ,  C09D7/70 ,  C04B38/0058 ,  C04B2103/0067

摘要： Disclosed is a solid foam, comprising frustules and/or frustule powder. Also disclosed is a method for making the solid foam comprising: [a.] forming a gel comprising frustules, [b.] sintering the frustules into a monolithic structure and [c]. calcining the gel. The gel maybe a cross-linked polyacrylamide formed from acrylamide and N-N-methylenebisacrylamide. Further disclosed is a method wherein the frustules comprise titanium dioxide comprising [a.] providing diatoms comprising organic matter and the frustules, [b.] providing a growing medium for the frustules, [c.] adding titanium complex, such as Ti-triethanolamine complex, to the growing medium of diatoms, and [d.] removing organic matter of the diatoms, by treating the diatoms with an acid and calcining, thereby uncovering frustule foams comprising titanium dioxide. The frustule foams comprising titanium dioxide can be used as photocatalysts in air purification systems.

公开(公告)号：EP2794052B1

公开(公告)日：2018-08-15

申请号：EP12809063.6

申请日：2012-12-17

申请人： 3M Innovative Properties Company

发明人： NAKAMURA, Masayuki ,  SUGIYAMA, Naota ,  ZOOK, Cynthia D. ,  AMOS, Stephen E. ,  RASMUSSEN, Jerald K. ,  GRYSKA, Nicole M.

IPC分类号： B01J20/32 ,  G01N33/543 ,  G01N33/552 ,  B01J20/28 ,  B01D15/38

CPC分类号： G01N1/405 ,  B01D15/3804 ,  B01J20/28004 ,  B01J20/28021 ,  B01J20/281 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3261 ,  B01J20/3291 ,  B01J2220/82 ,  C07K1/16 ,  C12N15/1006 ,  C12N15/101

摘要： A composition for use in bioseparation. The composition includes a plurality of hollow particles having a siliceous surface. The composition further includes a surface-modifying agent bonded to the hollow particles. The surface-modifying agent includes a binding segment and a reactive segment. The binding segment includes a silyl group and the reactive segment includes a reactive nitrogen group.

公开(公告)号：EP2960651B1

公开(公告)日：2017-12-20

申请号：EP14754797.0

申请日：2014-02-03

申请人： Hitachi High-Technologies Corporation

发明人： HAMASAKI, Koshin ,  SAITO, Toshiro

IPC分类号： G01N33/53 ,  G01N21/64 ,  G01N33/543 ,  G01N33/552 ,  G01N37/00

CPC分类号： G01N33/54333 ,  G01N21/6428 ,  G01N21/6486 ,  G01N33/54326 ,  G01N2021/6439

公开(公告)号：EP2864787B1

公开(公告)日：2017-11-01

申请号：EP13806909.1

申请日：2013-06-20

申请人： Bio-Rad Laboratories, Inc.

发明人： KING, David ,  LINK, William, F. ,  DEL ROSARIO, Renato ,  LEOS, Michael

IPC分类号： G01N33/552 ,  G01N33/551 ,  G01N33/543

CPC分类号： G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

摘要： The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：EP3172565A1

公开(公告)日：2017-05-31

申请号：EP15744286.4

申请日：2015-07-22

申请人： Loughborough University

发明人： EDWARDS, Alexander Daniel ,  REIS, Nuno Miguel Fernandes

IPC分类号： G01N33/552

CPC分类号： B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/161 ,  B01L2300/168 ,  B01L2400/0406 ,  B01L2400/0457 ,  G01N33/552

摘要： The present invention provides assay devices having a unitary body with an exterior surface, the unitary body being substantially transparent to visible light and formed from a material having a refractive index in the range 1.26 to 1.40, the refractive index being measured at 20° C. with light of wavelength 589 nm, and wherein the unitary body is formed from a hydrophobic material, and at least two capillary bores extending internally along the unitary body, wherein at least a portion of the surface of each capillary bore includes a hydrophilic layer for retaining an assay reagent, and wherein the hydrophilic layer is also substantially transparent to visible light to allow optical interrogation of the capillary bores through the capillary wall. The present invention also provides assay systems including such assay devices, methods of performing an assay using such assay devices and method of method for manufacturing such assay devices.

摘要翻译： 本发明提供了具有具有外表面的整体主体的测定装置，所述整体主体对可见光基本上是透明的并且由具有在1.26至1.40范围内的折射率的材料形成，所述折射指数在20℃下用 波长为589nm的光，并且其中整体由疏水性材料形成，并且至少两个毛细孔沿着整体本体内部延伸，其中每个毛细孔的至少一部分表面包括亲水层，用于保持 测定试剂，并且其中亲水层对可见光也基本上是透明的，以允许通过毛细管壁对毛细孔进行光学询问。 本发明还提供了包括这种测定装置的测定系统，使用这种测定装置进行测定的方法以及用于制造这种测定装置的方法。