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    Keratinocyte growth inhibitor, and treating agent or preventive and cosmetic of skin disease containing the same
    14.
    发明专利
    Keratinocyte growth inhibitor, and treating agent or preventive and cosmetic of skin disease containing the same 审中-公开
    杀菌剂生长抑制剂及其治疗剂或预防和化妆品的皮肤病

    公开(公告)号：JP2010189287A

    公开(公告)日：2010-09-02

    申请号：JP2009033209

    申请日：2009-02-16

    申请人： Toyo Hakko:Kk ,  株式会社東洋発酵

    发明人： SUNAGA MASARU ,  TAKADA ATSUSHI ,  NAGASHIMA SUNAO ,  MURAKAMI MASANORI

    IPC分类号： A61K36/18 ,  A61K8/97 ,  A61K36/25 ,  A61K36/48 ,  A61K36/53 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/12 ,  A61P43/00 ,  A61Q19/00

    CPC分类号： Y02A50/406

    摘要： PROBLEM TO BE SOLVED: To provide a keratinocyte growth inhibitor excellent in keratinocyte growth-inhibiting effect, a treating agent of a skin disease accompanied by the plague of keratinocyte, or a cosmetic which improves, suppresses or prevents the change in appearance of the skin accompanied by the plague of keratinocyte.
    SOLUTION: The keratinocyte growth inhibitor contains one or more plant bodies or extracts of the plant bodies as active components. The plant bodies are selected from the plants belonging to Sophora, Salvia, Saxifraga, Aralia, Typha, and Symphytum.
    COPYRIGHT: (C)2010,JPO&INPIT

    摘要翻译： 待解决的问题：为了提供角质形成细胞生长抑制效果优异的角质形成细胞生长抑制剂，伴有角化细胞病的皮肤病的治疗剂，或改善，抑制或防止外观变化的化妆品 皮肤伴有角质形成细胞的瘟疫。 解决方案：角化细胞生长抑制剂含有植物体的一种或多种植物体或提取物作为活性成分。 植物体选自属于苦参，丹参，萨克斯特氏菌，阿拉伯，蒲公英和西葫芦的植物。 版权所有（C）2010，JPO＆INPIT

    Ai-2 inhibitor
    15.
    发明专利
    Ai-2 inhibitor 审中-公开
    AI-2抑制剂

    公开(公告)号：JP2010159219A

    公开(公告)日：2010-07-22

    申请号：JP2009001608

    申请日：2009-01-07

    申请人： Kao Corp ,  花王株式会社

    发明人： KAWASAKI KEIKO ,  FUJINAKA EIGO ,  NAKAMURA JUNJI

    IPC分类号： A61K31/353 ,  A61P31/04 ,  A61P43/00

    CPC分类号： Y02A50/406 ,  Y02A50/471

    摘要： PROBLEM TO BE SOLVED: To provide an AI-2 (autoinducer-2) inhibitor inhibiting the activities of AI-2, and useful as a medicine, an unregulated drug or a food and drink for preventing, treating or ameliorating infectious disease.
    SOLUTION: The AI-2 inhibitor contains catechins in a concentration of 0.001-0.1 mM. The catechins are preferably one or more kinds selected from catechin, catechin gallate, gallocatechin, gallocatechin gallate, epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate in the AI-2 inhibitor.
    COPYRIGHT: (C)2010,JPO&INPIT

    摘要翻译： 要解决的问题：提供抑制AI-2活性的AI-2（自动诱导剂-2）抑制剂，可用作药物，不受管制的药物或用于预防，治疗或改善感染性疾病的食物和饮料 。 解决方案：AI-2抑制剂含有浓度为0.001-0.1mM的儿茶素类。 儿茶素类优选为AI-2抑制剂中的儿茶素，儿茶素没食子酸酯，儿茶素，没食子儿茶素，表儿茶素，表没食子儿茶素，表儿茶素没食子酸酯和表没食子儿茶素没食子酸酯中的一种以上。 版权所有（C）2010，JPO＆INPIT

    Dental plaque inhibitor
    17.
    发明专利
    Dental plaque inhibitor 审中-公开
    牙膏防腐剂

    公开(公告)号：JP2003048842A

    公开(公告)日：2003-02-21

    申请号：JP2001233390

    申请日：2001-08-01

    申请人： Kao Corp ,  花王株式会社

    发明人： SHIMOTOYOTOME REI ,  OKAJIMA MIYUKI ,  KOBAYASHI HISATAKA ,  KAMIDATE TAKASHI

    IPC分类号： A61K8/00 ,  A61K31/78 ,  A61P1/02 ,  A61Q11/00 ,  A61K7/16

    CPC分类号： Y02A50/406

    摘要： PROBLEM TO BE SOLVED: To provide a dental plaque inhibitor inhibiting the adsorption of salivary protein onto teeth surface as a cause of bacterial adsorption and thus inhibiting bacterial adsorption/infection and giving compositions for oral cavity that prevent oral cavity diseases.
    SOLUTION: This dental plaque inhibitor comprises a compound of the general formula (1) [where, l, m and n are such that the molar ratio l/m/n=(1-95):(5-80):(0-94) ((l+m+n)=100 mol%), 0.25≤(l+n)/m≤19; p is 1-22; q is 1-200; R
    1 , R
    2 , R
    3 and R
    4 are each H or a (F-substituted) hydrocarbon group; M
    1 , M
    2 and M
    3 are each H, a metal atom, ammonium group, 1-22C alkanolammonium group or basic amino acid residue].
    COPYRIGHT: (C)2003,JPO

    摘要翻译： 要解决的问题：提供抑制唾液蛋白质吸附到牙齿表面上作为细菌吸附原因并因此抑制细菌吸附/感染并给予预防口腔疾病的口腔用组合物的牙斑抑制剂。 解决方案：该牙斑抑制剂包含通式（1）的化合物[其中，l，m和n使得摩尔比l / m / n =（1-95）：（5-80）：（0 -94）（（1 + m + n）= 100摩尔％），0.25 <=（1 + n）/ m <= 19; p是1-22; q是1-200; R 1，R 2，R 3和R 4各自为H或（F-取代的）烃基; M 1，M 2和M 3各自为H，金属原子，铵基，1-22C链烷醇铵基或碱性氨基酸残基]。

    Novel sf-2259 substance and its preparation
    18.
    发明专利
    Novel sf-2259 substance and its preparation 失效
    新型SF-2259物质及其制备

    公开(公告)号：JPS59162891A

    公开(公告)日：1984-09-13

    申请号：JP3663783

    申请日：1983-03-08

    申请人： Meiji Seika Kaisha Ltd

    发明人： TAKIZAWA TOSHIO ,  MATSUHASHI NOBUO ,  SHIYOUMURA TAKASHI ,  YOSHIDA JIYUNKO ,  ITOU TATSUO ,  HIDAKA HIDEMASA

    IPC分类号： C07G99/00 ,  A61K35/74 ,  A61P1/02 ,  C12P1/06 ,  C12R1/29

    CPC分类号： Y02A50/406

    摘要： PURPOSE: To prepare the titled substance useful for the prevention and remedy of dental caries, by culturing a microbial strain belonging to Micromonospora genus and capable of producing the titled substance.
    CONSTITUTION: A microbial strain belonging to Micromonospora genus and capable of producing the novel physiologically active substance, SF-2259, e.g. Micromonospora sp. SF-2259 (FERM-P No.6953), is cultured, and the objective novel physiologically active substance SF-2259 is separated from the cultured product. The substance suppresses the activity of glucosyl transferase produced by Streptococcus mutans, the synthesis of dextran polysaccharide, and the formation of bactrial plague, and accordingly, it is effective to prevent or cure the dental caries.
    COPYRIGHT: (C)1984,JPO&Japio

    摘要翻译： 目的：制备可用于预防和治疗龋齿的标题物质，通过培养属于小单孢菌属的微生物菌株并能够生产标题物质。 构成：属于小单孢菌属的微生物菌株，能够产生新的生理活性物质，例如SF-2259。 小单孢菌 培养SF-2259（FERM-P No.6953），从培养物中分离出目的新型生理活性物质SF-2259。 该物质抑制由变形链球菌产生的葡糖基转移酶的活性，葡聚糖多糖的合成和生物瘟疫的形成，因此，有效预防或治愈龋齿。