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    PRODUCTION OF PROPYLENE CARBONATE
    23.
    发明专利
    PRODUCTION OF PROPYLENE CARBONATE 失效

    公开(公告)号：JPH07267944A

    公开(公告)日：1995-10-17

    申请号：JP5892094

    申请日：1994-03-29

    申请人： MITSUBISHI CHEM CORP

    发明人： IIMURA NORIKO ,  TAKAGI MASATOSHI ,  IWANE HIROSHI ,  OKAGO YUJI

    IPC分类号： C07D317/26 ,  B01J27/08 ,  C07B61/00

    摘要： PURPOSE:To provide an economically advantageous process for the production of propylene carbonate under milder reaction temperature and pressure condition at a high reaction rate in high yield by using an inexpensive alkali metal bromide and/or chloride as a catalyst. CONSTITUTION:This process for the production of propylene carbonate comprises the reaction of propylene oxide with carbon dioxide using an alkali metal bromide and/or chloride as a catalyst in the presence of 0.2-1 pt.wt. of an alcoholic solvent based on 1 pt.wt. of propylene oxide.

    PRODUCTION OF SPHINGOSINE USING TRIOL DERIVATIVE
    27.
    发明专利
    PRODUCTION OF SPHINGOSINE USING TRIOL DERIVATIVE 失效

    公开(公告)号：JPH0649054A

    公开(公告)日：1994-02-22

    申请号：JP16510093

    申请日：1993-06-10

    申请人： NOGUCHI KENKYUSHO

    发明人： INAZU TOSHIYUKI ,  YAMANOI TAKASHI

    IPC分类号： C07D317/20 ,  C07B53/00 ,  C07C215/24 ,  C07D317/26 ,  C07F9/655

    摘要： PURPOSE:To efficiently obtain at a low cost in a stereoselective way sphingosine as the essential constituent of sphingoglycolipids by reaction of a phosphonic ester derivative with an aldehyde to form a diol derivative which is then reduced. CONSTITUTION:Firstly, a phosphonic ester derivative of formula I (R' is methyl, ethyl, phenyl or benzyl) is made to react with an aldehyde in the presence of a base (e.g. cesium carbonate) in a solvent (e.g. isopropyl alcohol) to form a (4E)-1,2-isopropylidene-3-oxo-4-alkene-1,2-diol derivative of formula II (R is

    29.
    发明专利
    失效

    公开(公告)号：JPH05247047A

    公开(公告)日：1993-09-24

    申请号：JP8138492

    申请日：1992-03-04

    申请人： SAGAMI CHEM RES

    发明人： TERAJIMA ATSURO ,  KATO TADASHI ,  ARAI KATSUKO ,  AIHARA JUNKO ,  KOBAYASHI YUKO

    IPC分类号： A61K31/47 ,  A61K31/495 ,  A61P35/00 ,  C07D207/08 ,  C07D317/22 ,  C07D317/26 ,  C07D401/04 ,  C07D405/14 ,  C07D487/18

    摘要： PURPOSE:To obtain a new compound useful as an antitumor agent, having strong cell toxicity. CONSTITUTION:A compound of formula I (R is H or acyl; R is alkyl or aralkyl) such as (5R,7R,8S,11R,11aS)-7-cyano-5-hydroxymethyl-4-methoxy-13- methyl-5,7,8,9,10,11,11a,12-octahydro-8,11-azepino[1,2-b]isoquinoline. The compound of formula I is obtained by using 2-bromo-3-methylanisole of formula II as a starting substance, successively carrying out reactions to derive a compound of formula III (R is acyl; R is amino-protecting group), then replacing hydroxyl group at the 7-position of the compound of formula III with cyano group to give a compound of formula IV (R is H or amino-protecting group), eliminating the protecting group of amino group at the 13-position and alkylating or aralkylating the amino group at the 13-position.