Macrophage enhancement mri (memri)
    33.
    发明专利

    公开(公告)号:JP2010532223A

    公开(公告)日:2010-10-07

    申请号:JP2010515061

    申请日:2008-06-25

    IPC分类号: A61B5/055 A61K49/00

    摘要: 対象における癌の病期を評価する方法であり、対象にマクロファージ造影剤を投与するステップと、癌のリスクのある対象の身体領域の磁気共鳴映像を作成するステップと、画像を用いて、対象における任意の原発癌または転移癌に関連するマクロファージ密度および置換を評価するステップであり、このような密度および置換が新生物を示すステップを含む、方法が提供される。 マクロファージ造影剤は、小超常磁性酸化鉄粒子であり得、特定の実施形態では、マクロファージ造影剤は、癌のリスクのある領域全体でミクロファージ捕捉を可能にするために十分な血液半減期を有する。 追加的な実施形態は、対象における抗癌治療の効力を評価する方法、対象におけるフォローアップMEMRI評価の頻度を決定する方法、対象における癌病巣の転移可能性を決定する方法、および対象における癌の予後を決定する方法を提供する。

    System and method for detecting region where rigidity changed
    34.
    发明专利
    System and method for detecting region where rigidity changed 有权
    用于检测刚度变化的区域的系统和方法

    公开(公告)号:JP2010069295A

    公开(公告)日:2010-04-02

    申请号:JP2009207668

    申请日:2009-09-09

    IPC分类号: A61B8/08

    摘要: PROBLEM TO BE SOLVED: To provide a system and method for detecting a region where rigidity has been changed. SOLUTION: An ultrasonic imaging method for detecting a target region where the rigidity has been changed comprises a process to transmit a reference pulse to the target region so as to detect the initial position of the target region, a process to transmit a first pushing pulse having a first value of a variable parameter so as to displace the target region to a first displacement position, a process to transmit a first tracking pulse so as to detect the first displacement position of the target region, a process to transmit a second pushing pulse having a second value of the variable parameter so as to displace the target region to a second displacement position, and a process to transmit a second tracking pulse so as to detect the second displacement position of the target region. The ultrasonic imaging system for detecting the region where the rigidity changed is also provided. COPYRIGHT: (C)2010,JPO&INPIT

    摘要翻译: 要解决的问题:提供用于检测刚度已经改变的区域的系统和方法。 解决方案:用于检测刚度已经改变的目标区域的超声波成像方法包括将参考脉冲发送到目标区域以检测目标区域的初始位置的处理,发送第一 推动具有可变参数的第一值的脉冲,以将目标区域移位到第一位移位置;发送第一跟踪脉冲以检测目标区域的第一位移位置的处理;传送第二位置的处理 推动具有可变参数的第二值的脉冲,以将目标区域移位到第二位移位置,以及发送第二跟踪脉冲以便检测目标区域的第二位移位置的处理。 还提供了用于检测刚度变化的区域的超声波成像系统。 版权所有(C)2010,JPO&INPIT

    Method for detecting, localizing, and targeting internal sites in vivo using optical contrast agents, and system for detecting, localizing, and targeting internal site in living body using optical contrast agent
    37.
    发明专利
    Method for detecting, localizing, and targeting internal sites in vivo using optical contrast agents, and system for detecting, localizing, and targeting internal site in living body using optical contrast agent 审中-公开
    使用光学对比剂检测,定位和指定内部场所的方法,以及使用光学对比剂代替检测,定位和指定生活体内部位置的系统

    公开(公告)号:JP2009133876A

    公开(公告)日:2009-06-18

    申请号:JP2009072158

    申请日:2009-03-24

    发明人: BENARON DAVID A

    摘要: PROBLEM TO BE SOLVED: To rapidly image, localize, position and target a tissue inside a living body. SOLUTION: A system for detecting, localizing and targeting a medical instrument toward a target tissue within the body using an optical contrast agent in which a light source 102 is optically coupled to the tissue to be diagnosed 135; a light detector 174 is optically coupled to the tissue; to detect a portion of the light which passes through the tissue, and either one or both of the light source and light detector are coupled to the medical instrument 130 used in a medical procedure. A contrast locator engine 184 receives a signal from the detector and provides a target tissue output signal 195, based on the localization and distribution of the contrast agent, allowing the target tissue to be detected, located, or imaged, allowing the medical instrument to be positioned or targeted relative to the target tissue, and allowing the accuracy of placement or the progress of a procedure to be assessed, in real time. COPYRIGHT: (C)2009,JPO&INPIT

    摘要翻译: 要解决的问题:快速成像,定位和定位生物体内的组织。 解决方案:一种用于使用其中光源102光学耦合到要诊断的组织的光学造影剂来检测,定位和定向医疗器械朝向身体内的目标组织定位和定位的系​​统135; 光检测器174光学耦合到组织; 以检测通过组织的一部分光,并且光源和光检测器中的一个或两者耦合到医疗过程中使用的医疗器械130。 对比度定位器引擎184接收来自检测器的信号,并且基于造影剂的定位和分布提供目标组织输出信号195,允许检测,定位或成像目标组织,从而使医疗器械成为 相对于目标组织定位或定向,并且允许实时评估放置的准确性或程序的进展。 版权所有(C)2009,JPO&INPIT